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Introduces this special issue of Psychoanalytic Psychology. This special issue on Women, Psychoanalysis, and Gender is a commemoration of the capability, influence, acceptance, and authority of women in the community of psychoanalysis. In this issue, we turn to both new and more established voices in an expanded arena of gender, culture, and psychoanalysis. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Discusses the deconstructive shift in the conception of mothers and mothering from a unitary category of women in a biological relationship with their offspring to a more fluid constellation of active maternal relations. The author suggests a new parenting subject that transcends gender, constructed through the work of intersubjective dyads. Two questions are addressed: (1) How might the representation of such maternal relationships and their internalization be envisioned? (2) How might a changing conception of internalized maternal representations affect psychoanalytic practice? With reference to J. Bowlby's (1980) concept of internal working models of attachment, and to more recent infant research, the concept of maternal functions (specifically, functions of security, regulation, and recognition) is introduced as central to the mothering relation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Earlier studies have shown that some extracts of nonpolar lipids from lemon shark liver are able to stimulate the reticuloendothelial
system (RES) of experimental animals. This communication reports the identification of the coenzymes Q as the constituents
of a fraction from lemon shark liver lipid which showed intense biological activity. 相似文献
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Claudia R. Gordijo Khajag Koulajian Adam J. Shuhendler Leonardo D. Bonifacio Hui Yu Huang Simon Chiang Geoffrey A. Ozin Adria Giacca Xiao Yu Wu 《Advanced functional materials》2011,21(1):73-82
Recently, a new multifunctional, bio‐inorganic nanocomposite membrane with the ability to self‐regulate the release of insulin in response to blood glucose (BG) levels was reported. Herein, the application of this material as part of a small, implantable, closed‐loop insulin delivery device designed to continuously monitor BG concentrations and regulate insulin release is proposed. The insulin delivery device consists of a nanocomposite glucose‐responsive plug covalently bound to an insulin reservoir made of surface‐modified silicone. The plug is prepared with crosslinked bovine serum albumin (BSA) and enzymes (glucose oxidase (GOx) and catalase (CAT)), pH‐responsive hydrogel nanoparticles, and multifunctional MnO2 nanoparticles. The plug functions both as a glucose sensor and controlled delivery unit to release higher rates of insulin from the reservoir in response to hyperglycemic BG levels and basal insulin rates at normal BG concentration. The surfaces of the device are modified by silanization followed by PEGylation to ensure its safety and biocompatibility and the stability of encased insulin. Our results show that insulin release can be modulated in vitro in response to glucose concentrations. In vivo experiments show that the glycemia of diabetic rats can be controlled with implantation of the prototype device. The glucose‐responsiveness of the device is also demonstrated by rapid drop in BG level after challenging diabetic rats with bolus injection of glucose solution. In addition, it is demonstrated that surface PEGylation of the device is necessary for reducing the immune response of the host to the implanted foreign object and maintaining insulin stability and bioactivity. With this molecular architecture and the bio‐inorganic nanocomposite plug, the device has the ability to maintain normal BG levels in diabetic rats. 相似文献
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Monica Coll Anna Fernandez-Falgueras Anna Iglesias Bernat del Olmo Laia Nogue-Navarro Adria Simon Alexandra Perez Serra Marta Puigmule Laura Lopez Ferran Pico Monica Corona Marta Vallverdu-Prats Coloma Tiron Oscar Campuzano Josep Castella Ramon Brugada Mireia Alcalde 《International journal of molecular sciences》2022,23(20)
Molecular screening for pathogenic mutations in sudden cardiac death (SCD)-related genes is common practice for SCD cases. However, test results may lead to uncertainty because of the identification of variants of unknown significance (VUS) occurring in up to 70% of total identified variants due to a lack of experimental studies. Genetic variants affecting potential splice site variants are among the most difficult to interpret. The aim of this study was to examine rare intronic variants identified in the exonic flanking sequence to meet two main objectives: first, to validate that canonical intronic variants produce aberrant splicing; second, to determine whether rare intronic variants predicted as VUS may affect the splicing product. To achieve these objectives, 28 heart samples of cases of SCD carrying rare intronic variants were studied. Samples were analyzed using 85 SCD genes in custom panel sequencing. Our results showed that rare intronic variants affecting the most canonical splice sites displayed in 100% of cases that they would affect the splicing product, possibly causing aberrant isoforms. However, 25% of these cases (1/4) showed normal splicing, contradicting the in silico results. On the contrary, in silico results predicted an effect in 0% of cases, and experimental results showed >20% (3/14) unpredicted aberrant splicing. Thus, deep intron variants are likely predicted to not have an effect, which, based on our results, might be an underestimation of their effect and, therefore, of their pathogenicity classification and family members’ follow-up. 相似文献
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Ingrid D. Santaren Richard P. Bazinet Zhen Liu Luke W. Johnston John L. Sievenpiper Adria Giacca Ravi Retnakaran Stewart B. Harris Bernard Zinman Anthony J. Hanley 《Lipids》2019,54(10):617-627
Circulating fatty acids (FA) derived largely from dairy consumption have most commonly been measured in total human serum or phospholipid (PL) fractions, and have been used as validated biomarkers of dairy intake in a growing number of epidemiological studies. Nevertheless, measurement and characterization of a wider spectrum of FA biomarkers of dairy across the four major serum lipid fractions is lacking. This study aimed to (1) quantify FA biomarkers of dairy in PL, triacylglycerol (TAG), cholesteryl ester (CE), and unesterified fatty acid (FFA) serum lipid fractions; and (2) identify potential demographic and metabolic factors that may modify the proportions of these FA across serum fractions. Baseline data from 444 adults in the PROMISE cohort were analyzed. FA biomarkers, 15:0, t16:1n-7, 18:2-c9,t11, and t18:1n-7 were quantified from serum. Dairy intake was estimated using the validated Canadian Diet History Questionnaire. Our results show that t18:1n-7 was the most abundant FA biomarker in all fractions except CE, where 18:2-c9,t11 was the most abundant. Positive correlations within fractions, and across FA in the PL, CE, and FFA fractions were found, however, TAG FA were negatively correlated with the other fractions. PL and CE FA were positively associated with dairy intake, and negatively associated with markers of dysmetabolism while, in contrast, these markers were predictors of higher TAG dairy FA. This study is the first to demonstrate distinct proportions of dairy FA in different serum lipid fractions. PL and CE FA marked dairy intake in this cohort, while TAG FA appeared to be markers of dysmetabolism. 相似文献
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A review of the frequency regulation market practices of the ISO New England, PJM Interconnection, and Midcontinent ISO is presented here. Particular attention is given to market structure, resource eligibility, selection, market clearing and settlements. An overview of frequency regulating reserves and the capacity and performance components is provided. We find that the observed spread in historic market clearing prices can be explained by how each operator incorporates lost opportunity cost into their clearing formulation. 相似文献