How great is radiation exposure in the area surrounding patients after administration ov 99mTc-sestamibi?

AIM: The aim of the present study was to estimate the additional radiation exposure to personnel, other patients and members of the family caused by patients who had been injected with 99mTc-Sestamibi (Cardiolite DuPONT PHARMA) for preoperative localization of parathyroid adenoma. METHODS: Dose rates were measured from 16 patients who had received an intravenous injection of 600 +/- 50 MBq 99mTc-Sestamibi. All measurements were performed with a portable dosimeter (Berthold LB 133) at 3 different distances (0.5, 1 and 2 m) at 10 min, 180-200 min and 24 h after administration of the tracer. RESULTS: The dose rates amounted to 20.5 microSv/h at 0.5 m, 5.25 microSv/h at 1 m and 1.55 microSv/h at 2 m distance from patients respectively. The biological half-life was 54 h. The calculated maximal dose to other persons in the waiting area was 31.2 microSv, to family members 27.6 microSv and to nurses in a ward 31.2 microSv. CONCLUSION: Our results indicate that the calculated maximal radiation exposure for personnel, family members and other patients even under very unfavourable conditions was below the maximal allowed dose for non-professionally exposed persons.     

A formal model of composing components: the TLA+ approach

In this paper, a method for writing composable TLA⁺ specifications that conform to the formal model called Masaccio is introduced. Specifications are organized in TLA⁺ modules that correspond to Masaccio components by means of a trace-based semantics. Hierarchical TLA⁺ specifications are built from atomic component specifications by parallel and serial composition that can be arbitrary nested. While the rule of parallel composition is a variation of the classical joint-action composition, the authors do not know about a reuse method for the TLA⁺ that systematically employs the presented kind of a serial composition. By combining these two composition rules and assuming only the noninterleaving synchronous mode of an execution, the concurrent, sequential, and timed compositionality is achieved.     

Aerodynamic optimization via multi-objective micro-genetic algorithm with range adaptation,knowledge-based reinitialization,crowding and ε-dominance

In this study, an optimization of the airfoil of a sailplane is carried out by a recently developed multi-objective genetic algorithm based on microevolution, containing crowding, range adaptation, knowledge-based reinitialization and ε-dominance. Its efficiency was tested on a set of test problems. The results are encouraging, suggesting that very small populations can be used effectively to solve real-world multi-objective optimization problems in many cases of interest.     

New voltage-mode universal filter and sinusoidal oscillator using only single DBTA

In this article, a new voltage-mode second-order universal frequency filter and sinusoidal oscillator using only single differential-input buffered and transconductance amplifier (DBTA) is presented. The proposed voltage-mode filter structure using single DBTA and four passive elements can provide all standard filter functions, i.e. low-, band-, high-pass, band-stop, and all-pass without changing the circuit topology and enables independent control of the quality factor Q using single passive element. The circuit requires the minimal number of active and passive elements with no conditions for component matching. By slight modification of the proposed filter structure, the new DBTA-based sinusoidal oscillator is easily obtained. The oscillation condition and the oscillation frequency are independently adjustable by different virtually grounded passive elements. The proposed sinusoidal oscillator employs only grounded capacitors. The passive and active sensitivities of all the proposed circuit configurations are low. PSPICE simulations using a BJT realisation of DBTA and experimental results based on commercially available amplifiers OPA860 and MAX436 are included, which prove the workability of the proposed circuits.     

Voltage-mode multifunction filter with mutually independent Q and \omega _0 control feature using VDDDAs

The paper focuses on the application possibilities of the newly presented voltage differencing active building block called voltage differencing differential difference amplifier. Using this active element, a multifunction frequency filter is designed featuring the possibility of mutually independent control of quality factor Q and characteristic frequency \(\omega _0\) by means of active elements. The structure of the filter is based on the idea of the Akerberg-Mossberg (AM) filter, i.e. the integrators in the structure are always realized only by two active elements. This fact results in better phase compensation for the filter. Compared to the AM opamp based filter, the newly proposed structure features high-impedance inputs, low-impedance output, and all basic frequency responses. The performance of the proposed structure has been verified by SPICE simulations using the TSMC \(0.18\,\upmu \hbox {m}\) level-7 SCN018 CMOS process parameters with \(\pm 0.9\,\hbox {V}\) supply voltage.     

New resistorless and electronically tunable realization of dual-output VM all-pass filter using VDIBA

In this paper, a new active element called voltage differencing inverting buffered amplifier (VDIBA) is presented. Using single VDIBA and a capacitor, a new resistorless voltage-mode (VM) first-order all-pass filter (APF) is proposed, which provides both inverting and non-inverting outputs at the same configuration simultaneously. The pole frequency of the filter can be electronically controlled by means of bias current of the internal transconductance. No component-matching conditions are required and it has low sensitivity. In addition, the parasitic and loading effects are also investigated. By connecting two newly introduced APFs in open loop a novel second-order APF is proposed. As another application, the proposed VM APF is connected in cascade to a lossy integrator in a closed loop to design a four-phase quadrature oscillator. The theoretical results are verified by SPICE simulations using TSMC 0.18 μm level-7 CMOS process parameters with ±0.9 V supply voltages. Moreover, the behavior of the proposed VM APF was also experimentally measured using commercially available integrated circuit OPA860 by Texas Instruments.     

An electronically tunable current-mode quadrature oscillator using PCAs

This article presents a new realisation of active RC sinusoidal oscillator with electronically tunable condition and frequency of oscillation (FO). As compared to the class of three resistors, two capacitors (3R-2C)-based canonic oscillators, the circuit proposed here uses only two resistors and two capacitors as the passive components and still provides non-interactive tuning laws for the condition of oscillation and the FO. The proposed circuit employs new bipolar programmable current amplifier as the active building block and is capable of simultaneously providing two explicit quadrature current outputs. SPICE simulation results have been included to verify the workability of the circuit as an oscillator and the tuning range of the FO.     

Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes

BACKGROUND: Isoflavones and coumestrol from dietary legumes are plant constituents showing multiple beneficial effects on humans. Owing to their ability to bind with mammalian estrogenic receptors and thereby intervention in several kinds of hormone‐related cancers, they have received much attention. Soybean (Glycine max) is currently the major source of isoflavonoids in human diet. However, dozens of tropical and subtropical leguminous species remain unexplored for their isoflavonoids content. RESULTS: We have analyzed 55 extracts from 41 tropical and subtropical legume species used either in human or animal diet by high‐performance liquid chromatography for the content of soy isoflavones, biochanin A, daidzein, daidzin, formononetin, genistein, genistin, sissotrin, ononin and the coumestan coumestrol. Genistein and biochanin A were the most abundant compounds. The highest content of genistein was found in aerial parts of Andira macrothyrsa, seeds of Pachyrhizus tuberosus and aerial parts of Calopogonium mucunoides (598, 250 and 184 µg g^?1, respectively) and biochanin A in aerial parts of Cratylia argentea, C. mucunoides and flowers of A. macrothyrsa (76, 53 and 40 µg g^?1, respectively). CONCLUSION: None of the samples tested was richer overall source of soy isoflavones and coumestrol than soybean; nevertheless several species (C. mucunoides or A. macrothyrsa) may serve as a promising source of individual compounds. © 2012 Society of Chemical Industry     

Determination of micromechanical properties of a hen’s eggshell by means of nanoindentation

The work describes the suitability and applicability of the nanoindentation method for the determination of the micromechanical properties of a hen’s eggshell. The values of elastic modulus E were monitored in five different locations along the eggshell’s meridian line. Detailed maps of elastic moduli at particular eggshell cross-sections revealed high variations in local values of E-moduli at individual points, but not significant differences of their means at distant parts of the eggshell. Mean values of E-modulus in different meridian positions did not vary significantly and ranged from 47.4 to 53 GPa. Experimental histograms were created of all elastic moduli showing the frequency of their occurrence and these revealed a rather high variation in E-moduli throughout the cross-section. The probability density function can be characterised by a symmetrical shape and the distribution of E-moduli can be approximated with the Gauss distribution. The nanoindentation technique proved to be a suitable, easy-to-use, and powerful tool for assessing local variations of the mechanical properties of hen’s eggshells.