Anti-proliferative effects of a small molecule inhibitor of CDK AT7519 on chronic myeloid leukemia (CML) cells through halting the transition of cells from G2/M phase of the cell cycle

Pathogenesis of chronic myeloid leukemia (CML) has mostly been studied with regard to the oncogenic roleof BCR/ABL fusion; however, recent disclosures have declared that the challenges with the treatment of CML patientswould not be resolved until the role of other aberrancies is ignored. Given the involvement of cyclin-dependent kinases(CDKs) in the pathogenesis of CML, the present study aimed to investigate the effects of a multi-CDK inhibitorAT7519 on BCR/ABL-harboring CML-derived K562 cells. Our results showed that AT7519 effectively reduced thesurvival of K562 and induced its anti-proliferative effect through the induction of G2/M arrest due to elevated p21and p27. The resulting data also revealed that either direct or indirect suppression of c-Myc using specific c-Mycinhibitor 10058-F4 and selective PI3K inhibitor CAL-101 resulted in a superior cytotoxicity, suggesting that theactivation of PI3K pathway could attenuate antileukemic effects of the inhibitor, at least partly, through a c-Mycdependent mechanism. To the best of our knowledge, to date, no study has addressed the effect of autophagy onCML cell response to AT7519, and, herein, we proposed for the first time that the suppression of autophagyboosted AT7519 cytotoxicity against K562. Overall, we suggested that selective CDK inhibitor AT7519 exertedantileukemic effect against CML cells and propose a novel therapeutic application for the inhibitor either as a singleagent or in combination with c-Myc and/or PI3K inhibitors.     

减少离散大系统两级镇定控制的保守性

The aim of this paper is to propose a new algorithm for multilevel stabilization of large scale systems. In two-level stabilization method, a set of local stabilizers for the individual subsystems in a completely decentralized environment is designed. The solution of the control problem involves designing of a global controller on a higher hierarchical level that provides corrective signals to account for interconnections effect. The principle feature of this paper is to reduce conservativeness in global controller design. Here, the key point is to reduce the effect of interactions instead of neutralizing them. In fact, unlike prior methods, our idea does not ignore the possible beneficial aspects of the interactions and does not try to neutralize them.     

On the design of observers for generalized state space systems using singular value decomposition

In this paper a method is developed for the design of Luenberger-type observers for linear time-invariant control systems whose state equation is of the form Ex= Ax+ Bu where E is a singular square matrix. The method is based on the singular-value decomposition of the matrix E, and on the reduction of the equation Ex= Ax +Bu to a system consisting of a differential equation of the form w₁, = F₁w₁ + F₂ + w₂ +G₁u and an algebraic equation of the form H₁w₁ +H₂w₂ + G₁u = 0. If w₂ can be eliminated from the differential equation by the aid of the algebraic equation and the original output equation of the system, the method yields a reduced-order observer for the generalized state space system.     

A simulation study on autonomous decentralized mechanism in fish behaviour model

The behaviour of a fish school is considered an interesting phenomenon because a fish school behaves differently in various situations. The paper considers a fish school as an autonomous decentralized system and constructs a mathematical model for the autonomous decentralized mechanism. Simulation results show that, by varying the quantity of information exchange among members in school, the present model describes fish behaviour not only for a school with fixed configuration but also for that with variable form. Furthermore, a remarkable difference in fish trajectory is found between the two schools.     

核电结构材料应力腐蚀开裂初始阶段裂尖驱动力的研究

裂尖力学状态是影响核电结构材料应力腐蚀开裂(SCC)扩展速率的主要因素之一。为了搞清SCC不同扩展阶段裂尖驱动力的变化及其对SCC扩展速率的影响,本文建立了SCC扩展不同阶段的有限元模型,详细分析了裂纹初始阶段影响裂尖应力状态的工作载荷、残余应力,以及氧化膜形成过程中产生的膜致应力。结果表明,在SCC裂纹初始阶段,裂尖氧化膜形成所产生的“锲入张力”是SCC的主要驱动力;随着裂纹的扩展,工作载荷和残余应力逐渐成为SCC裂纹扩展的主要驱动力。     

冷轧加工纳米结构Ti_(50)Ni_(48)Co_2形状记忆合金的超弹性行为（英文）

研究冷轧后退火对Ti_(50)Ni_(48)Co_2形状记忆合金显微组织演化和超弹性性能的影响。结果表明,在冷轧制过程中,合金的显微组织经历了应力诱导马氏体相变和马氏体塑性变形、变形孪晶、马氏体中沿孪晶和不同晶界的位错堆积、纳米晶化、非晶化以及马氏体向奥氏体的可逆相变6个基本阶段。在400℃退火1 h后,冷轧样品中形成的非晶相完全晶化,生成了一个完全纳米晶体的结构。这种纳米晶体合金的峰应力高达730 MPa,明显高于粗晶Ni_(50)Ti_(50)和Ti_(50)Ni_(48)Co_2合金。而且,纳米晶Ti_(50)Ni_(48)Co_2合金具有较高的阻尼容量和较好的储能效率。     

On sufficient conditions for the stability of interval matrices

Using Gershgorin's diagonal dominance theorem, new sufficient conditions for the stability of interval matrices are obtained. The new conditions remove a restriction in Heinen's (1983) analysis and are applicable to a wider class of problems than previously possible.