p53 codon 72 polymorphism in Taiwanese lung cancer patients: association with lung cancer susceptibility and prognosis

Previous studies have indicated that milrinone, a specific type III phosphodiesterase inhibitor, may be able to induce chloride secretion in cystic fibrosis (CF) tissues. We have now assessed the effect of this agent in vivo on the nasal epithelium of CF mutant mice and also in the nose and lungs of human subjects with CF. Wild-type mice showed a small hyperpolarization of the nasal potential difference (PD) in response to milrinone (100 microM, 1.6 +/- 0.6 mV, n = 8, P < 0.05). In contrast, CF mice carrying either the most common human mutation of the gene for the CF transmembrane regulator (CFTR), DeltaF508 (protein mislocalized), or the G551D mutation (protein normally localized) failed to demonstrate this response. Milrinone perfused alone had no significant effect on the baseline nasal PD of human subjects without CF (14.7 +/- 4.0 mV preperfusion; 15.3 +/- 4.6 mV postperfusion), but significantly (P < 0.05) augmented the hyperpolarization induced by a subsequently perfused low-chloride solution (with milrinone, 36.8 +/- 3.0 mV, n = 6; without milrinone, 18.1 +/- 2.2 mV, n = 19). In contrast, in human subjects with CF (n = 6), milrinone alone significantly (P < 0. 05) altered the nasal baseline PD (52.2 +/- 3.3 mV preperfusion; 57. 4 +/- 4.2 mV, postperfusion) but not the subsequent responses to the low-chloride solution (with milrinone, 1.1 +/- 2.2 mV, n = 4; without milrinone, 0.6 +/- 0.5 mV, n = 28) or to isoproterenol (100 microM). In a separate study in subjects (n = 6) with the DeltaF508 mutation, nasal coadministration of milrinone with isoproterenol produced no effect in the presence of amiloride and a low-chloride solution (-0.8 +/- 0.5 mV). This was also the case in the nasal epithelium of CF subjects (n = 4) carrying at least one G551D allele (-0.3 +/- 0.8 mV). Similarly, milrinone did not hyperpolarize the PD of either the tracheal (n = 6) or segmental (n = 6) airways of CF subjects (DeltaF508) when applied topically in vivo in the presence of amiloride, isoproterenol, or adenosine triphosphate (all 100 microM) in a low-chloride solution. These data do not support the use of milrinone to induce chloride secretion in CF airways in vivo.     

A pairing-free identity-based authenticated group key agreement protocol for imbalanced mobile networks

The secure and reliable group communication gains popularity in imbalanced mobile networks due to the increase demand of the group-oriented applications such as teleconferences, collaborative workspaces, etc. For acquiring the group security objectives, many authenticated group key agreement (AGKA) protocols exploiting the public key infrastructure have been proposed, which require additional processing and storage space for validation of the public keys and the certificates. In addition, the most of the AGKA protocols are implemented using bilinear pairing and a map-to-point (MTP) hash function. The relative computation cost of the bilinear pairing is approximately two to three times more than the elliptic curve point multiplication (ECPM) and the MTP function has higher computation cost than an ECPM. Due to the limitation of communication bandwidth, computation ability, and storage space of the low-power mobile devices, these protocols are not suitable especially for insecure imbalanced mobile networks. To cope with the aforementioned problems, in this paper, we proposed a pairing-free identity-based authenticated group key agreement protocol using elliptic curve cryptosystem. It is found that the proposed protocol, compared with the related protocols, not only improves the computational efficiencies, but also enhances the security features.     

Study of various shapes of the coupling slot in CPW-fed microstripantennas

A numerical modeling based on the solution of coupled integral equations is used for the characterization of CPW-fed aperture-coupled microstrip antennas. Various shapes of excitation slots, such as open stubs, slot loops, and capacitively and inductively coupled slots, are investigated in terms of return loss and front-to-back radiated power ratio. It is shown that a centered CPW open stub gives a minimum of back radiation while allowing for easy matching. The slot-loop excitation seems to be a convenient feeding mechanism that also allows the insertion of active devices     

Very compact double C-patch antenna

A miniaturised C-patch antenna excited by means of a coaxial probe is described. The antenna consists of two stacked C-shaped elements connected together with a vertical conducting plane. The antenna is designed on an air substrate and offers attractive dimensions, being five times lower than those of a conventional half wavelength microstrip patch antenna operating at the same frequency. A 10 dB bandwidth of 3% is obtained. The voltage standing wave ratio, radiation patterns, and electric surface current density are presented     

Antenne double C: un élément de tres petites dimensions

One can reduce dramatically the sizes of the planar antennas by introducing short-circuits in the structure of the antennas. In this paper, we present a miniaturized C-patch antenna excited by means of a coaxial probe. The antenna consists of two stacked C-shaped elements connected together with a vertical conducting plane. The antenna is designed on an air substrate and offers attractive dimensions, being five times lower than those of a conventional half wavelength microstrip patch antenna operating at the same frequency. Firstly, one presents the optimal geometry of the antenna and the results of the simulations which are compared with measurements in regard to the input impedance and radiation patterns. From this optimal configuration, a study parametric has been investigated for the all sizes of the antenna, in order to show the influence of each one on the resonance fre quency and the bandwidth. We will present also an application where this antenna is used in a proximity communication system between two computers.     

Design and analysis of an improved smartcard‐based remote user password authentication scheme

With the fast development of the Internet and the telecommunication technologies, internet users are carrying out various electronic transactions over internet by means of the authentication protocols. To ensure efficient and robust online transaction, security of authentication protocol turns out to be a great concern nowadays. As a result, smartcard‐based password authentication and session key agreement scheme receives significant attention in recent years. In the literature, various authentication schemes have been proposed by the cryptographic research community. Recently, Li et al. analyze some security weaknesses of the authentication scheme of Chen et al. and propose an enhancement based on the discrete logarithm problem and computational Diffie–Hellman problem. This paper further cryptanalyzes the scheme of Li et al. and identifies various security loopholes and then constructs a modified authentication scheme as a remedy. The security and efficiency evaluations demonstrate that our scheme has more security features and low computation costs than the related schemes. Copyright © 2014 John Wiley & Sons, Ltd.     

Osmolality changes in perilymph after systemic administration of glycerin

Blood osmolality was altered in guinea pigs by intravenous administration of glycerin (glycerol). After glycerin administration, serum osmolality increased rapidly, reaching a plateau within 15 minutes. Perilymph osmolality lagged significantly behind the increase of serum osmolality and equalled serum osmolality only after one hour. While perilymph osmolality responded to changes of serum osmolality, there was some time lag noted in the response of perilymph, suggesting the existence of a blood-labyrinth barrier. It was observed that this barrier is permeably to glycerin and water, suggesting the possibility of transient reduction of hydrostatic pressure in the labyrinth by the injection of an osmotic agent into the systemic circulation.