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排序方式: 共有809条查询结果,搜索用时 31 毫秒
1.
Klaus Reinhardt Hans Georg Breunig Aisada Uchugonova Karsten K?nig 《Journal of the Royal Society Interface》2015,12(110)
We explore the possibility of characterizing sperm cells without the need to stain them using spectral and fluorescence lifetime analyses after multi-photon excitation in an insect model. The autofluorescence emission spectrum of sperm of the common bedbug, Cimex lectularius, was consistent with the presence of flavins and NAD(P)H. The mean fluorescence lifetimes showed smaller variation in sperm extracted from the male (tau m, τm = 1.54–1.84 ns) than in that extracted from the female sperm storage organ (tau m, τm = 1.26–2.00 ns). The fluorescence lifetime histograms revealed four peaks. These peaks (0.18, 0.92, 2.50 and 3.80 ns) suggest the presence of NAD(P)H and flavins and show that sperm metabolism can be characterized using fluorescence lifetime imaging. The difference in fluorescence lifetime variation between the sexes is consistent with the notion that female animals alter the metabolism of sperm cells during storage. It is not consistent, however, with the idea that sperm metabolism represents a sexually selected character that provides females with information about the male genotype. 相似文献
2.
Changmo Kim Izhar Livne‐Bar Karsten Gronert Jeremy M. Sivak 《Molecular nutrition & food research》2020,64(4)
Lipoxins (LXs) are autacoids, specialized proresolving lipid mediators (SPMs) acting locally in a paracrine or autocrine fashion. They belong to a complex superfamily of dietary small polyunsaturated fatty acid (PUFA)–metabolites, which direct potent cellular responses to resolve inflammation and restore tissue homeostasis. Together, these SPM activities have been intensely studied in systemic inflammation and acute injury or infection, but less is known about LX signaling and activities in the central nervous system. LXs are derived from arachidonic acid, an omega‐6 PUFA. In addition to well‐established roles in systemic inflammation resolution, they have increasingly become implicated in regulating neuroinflammatory and neurodegenerative processes. In particular, chronic inflammation plays a central role in Alzheimer's disease (AD) etiology, and dysregulated LX production and activities have been reported in a variety of AD rodent models and clinical tissue samples, yet with complex and sometimes conflicting results. In addition, reduced LX production following retinal injury has been reported recently by the authors, and an intriguing direct neuronal activity promoting survival and homeostasis in retinal and cortical neurons is demonstrated. Here, the authors review and clarify this growing literature and suggest new research directions to further elaborate the role of lipoxins in neurodegeneration. 相似文献
3.
Gang Guo Guangli Liu Karsten E. Thompson 《Chemical Engineering Communications》2003,190(12):1641-1660
Many engineering problems require the estimation of mass transfer coefficients in porous materials. In heterogeneous materials or in cases where mass transfer sites are not spatially uniform, empirical equations for mass transfer coefficients vary widely, and the origin of these differences is not well understood. In this article, we use a stochastic algorithm to model mass transfer from single particles in a two-dimensional heterogeneous packed bed. The computed mass transfer coefficients are used to generate a distribution of local Peclet numbers in the bed. Detailed hydrodynamics are then used to interpret variations in the local Peclet number. The results show clear relationships between pore structure, streamline patterns, and mass transfer rates. 相似文献
4.
Julie Ann Wambach 《Behaviour & Information Technology》1995,14(3):183-195
The electronic mail (EM) network in a large, multi-campus community college district was used by some employees to gain support for positions contrary to those of the leadership. The case study offered an opportunity to look at technology within an organizational setting. It raised questions about the loose coupling of the educational organization's technical and authority systems, about the strength of coupling among employee groups during the incident, about the boundaries of the EM political activists, and about the power manifested within educational organization's technical and authority systems. A variety of research methods (stages of event progression, fantasy types associated with consciousness-building, and evidence of user technical and rhetorical skills) were used to answer questions about the organization's loosely coupled systems during the EM political incident. Notes were taken of conversations and more formal interviews. From this the technical and authority systems of the institution were described and compared. Results indicated that (1) the loose coupling of the technical and the authority systems made the EM political incident possible; (2) employees were more tightly coupled on organizational goals and more loosely coupled on organizational means; (3) political activists did not make full use of the EM's political medium potential; and (4) when the college district's administration refused to limit anyone's use of the EM network, they reinforced the integrity of both the authority and the technical systems.
Implications included: (1) the potential of some of the research methods for EM study, especially fantasy theme analysis; (2) a political interpretation of EM language, especially flaming; (3) the importance of technical and rhetorical skills for mature EM users; and (4) the role of the authority and technical systems in the debate about appropriate EM network use within an organization. 相似文献
Implications included: (1) the potential of some of the research methods for EM study, especially fantasy theme analysis; (2) a political interpretation of EM language, especially flaming; (3) the importance of technical and rhetorical skills for mature EM users; and (4) the role of the authority and technical systems in the debate about appropriate EM network use within an organization. 相似文献
5.
Köhler K Lellouch AC Vollmer S Stoevesandt O Hoff A Peters L Rogl H Malissen B Brock R 《Chembiochem : a European journal of chemical biology》2005,6(1):152-161
Cellular signal transduction proceeds through a complex network of molecular interactions and enzymatic activities. The timing of these molecular events is critical for the propagation of a signal and the generation of a specific cellular response. To define the timing of signalling events, we introduce the combination of high-resolution confocal microscopy with the application of small-molecule inhibitors at various stages of signal transduction in T cells. Inhibitors of Src-family tyrosine kinases and actin dynamics were employed to dissect the role of the lymphocyte-specific tyrosine kinase Lck in the formation and maintenance of T cell receptor/CD3-dependent contacts. Anti-CD3epsilon-coated coverslips served as a highly defined stimulus. The kinetics of the recruitment of the yellow fluorescent protein-tagged signalling protein ZAP-70 were detected by high-resolution confocal microscopy. The analysis revealed that at 5 min after receptor engagement, Lck activity was required for maintenance of contacts. In contrast, after 20 min of receptor engagement, the contacts were Lck-independent. The relevance of the timing of inhibitor application provides a pharmacological concept for the maturation of T cell-substrate contacts. 相似文献
6.
P. E. Højlund Nielsen Karsten Pedersen J. R. Rostrup-Nielsen 《Topics in Catalysis》1995,2(1-4):207-221
The kinetics of hydrocarbon synthesis over sulfide-based catalysts was studied. It appears that the formation of methane follows another reaction path than that of higher hydrocarbons. This might explain the very high selectivities for ethane and propane as compared with conventional Fischer-Tropsch catalysts. Reference is made to testing of the catalysts at industrial conditions. 相似文献
7.
8.
The adhesion and interfacial properties of polyurethane (PU) foams with thermoplastic (TP) materials were investigated using different techniques. The adhesion performance of PU foam with TP materials was evaluated using the peel test method, and the adhesion durability was checked after different climate treatments. X‐ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and contact angle measurements were used to study the surface and interface morphology of PU foam and TP material system. Three types of PU foam samples which differ in their composition and also five commercially available TP blends systems, based on poly(carbonate), poly(styrene‐co‐maleic anhydride), poly(acrylonitrile‐butadiene‐styrene), and silicone acrylate rubber have been used. The slow reacting foam shows the best adhesion properties with all the TP materials. The climate treatments strongly effected the PU foam adhesion durability with poly(carbonate) containing TP materials (70–80% loss in adhesion), but nearly no effect with poly(styrene‐co‐maleic anhydride). The samples with lowered adhesion could be separated by peeling without visible foam residues on the TP surface. AFM, XPS, and surface tension studies have shown that the surface properties of the TP material are still governed by the PU foam. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 479–488, 2007 相似文献
9.
Erika Leitel Wolfgang Hübner Karsten P. Thiessen Ju. B. Makari
ev A. G. Akimov 《工业材料与腐蚀》1988,39(1):1-7
Investigation into the passivation mechanism of iron in phosphate electrolytes on surfaces exposed to erosive attack On iron electrodes in neutral phosphate electrolytes by continuous solid particle impingement a reaction layer is formed within the transition potential region under anodic polarization. XPS and AES investigations show that the reaction layer formed under impingement will be replaced by an oxide layer during the transition into the passive state under simultaneous decrease of the layer thickness. The active/passive transition in phosphate electrolytes may be attached to the equilibrium potential of the reaction . According to this thermodynamic interpretation of both the active/passive transition and the passive/active transition, respectively on iron in presence of phosphate ions may be described as the Fe(II)/Fe(III)-redox reaction with two solid phases, the iron(II)-phosphate phase and the iron(III)-oxide phase. The increase of the interfacial dynamic processes at the solid/liquid interface causes in consequence of the solid particle impingement that thermodynamic laws govern the course of reactions. 相似文献
10.