Role of Metabolism in Bone Development and Homeostasis

Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.     

Dynamical Properties of Vortices in a Bose-Einstein Condensate in a Rotating Lattice

We present simulation results of the vortex dynamics in a trapped Bose-Einstein condensate in the presence of a rotating optical lattice. Changing the potential amplitude and the relative rotation frequency between the condensate and the optical lattice, we find a rich variety of dynamical phases of vortices. In particular, when the optical lattice rotates faster than the condensate, the competition between the pinning force and the interactions by nucleated interstitial vortices leads to the melting of vortex lattice, yielding a vortex liquid phase.     

Superconductivity in SrTa2S5

A strontium tantalum sulfide, SrTa₂S₅, has a hexagonal structure with lattice constants of a =3.32 and c=24.1 Å. With decreasing temperature the electrical resistivity decreases monotonically and exhibits an abrupt superconducting transition at 3.16 K (midpoint). The diamagnetic susceptibility is observed below T_c. The magnetic susceptibility is nearly independent of temperature above T_c and shows Pauli paramagnetism.     

Analytic Approximation to The Standard Error of Swap-Rate

When we select No students from N applicants on the basis of a composite score of subtests, it is important to evaluate the contribution of each subtest. The swap-rate, which is defined as the proportion of the applicants who actually pass the examination but would fail if the j-th subtest were not included in the component to rank the applicants, is one of the measures of the contribution of the j-th subtest.

In this article, first, we derive the characteristics and limiting properties of the population swap-rate. Next, using the properties of the order statistics and the extended hypergeometric distribution, we derive an approximation to the asymptotic variance of the sample swap-rate when the number of applicants is large. Finally, we propose the use of our analytic approximation to the variance of the sample swap-rate in the real data problem and show that it is very efficient.

     

Development of 170 GHz/500 kW gyrotron

A development of 170GHz/500kW level gyrotron was carried out as R&D work of ITER. The oscillation mode is TE_31,8. In a short pulse experiment, the maximum power of 750kW was achieved at 85kV/40A. The efficiency was 22%. In the depressed collector operation, 500kW/36%/50ms was obtained. The maximum efficiency of 40% was obtained at P_RF=470kW whereas the power decrease by the electron trapping was observed. Pulse extension was done up to 10s at P_RF=170kW with the depressed collector operation. The power was limited by the temperature increase of the output window.     

Synthesis of fine composite particles for hydrogen storage, starting from Mg-YNi2 mixture

We synthesized new composite particles for hydrogen storage on the basis of an idea of “particle designing”. As starting materials, powders of Mg and YNi₂ were selected. Fine composite particles containing mainly Mg₂Ni could be designed by repetitive hydriding and dehydriding cycles at 673 K. In the synthesis process of the composite particles, the following two points were found to be essential for this technique. The first point is that, after being activated by the sequential processes of hydrogenation, amorphization and disproportionation, YNi₂ reacts effectively with Mg. The second point is that evaporated Mg, which occurs during dehydriding, adheres to the surface of the activated YNi₂ and accelerates a diffusion reaction to form Mg₂Ni at the interface. In these composite particles, Mg₂NiH₄ is formed, even at 373 K, under a hydrogen pressure of 5 MPa.     

Surface characterization and catalytic properties of La1−x -Sr x CoO3

The surface chemical states of the perovskite-type compounds, strontium doped lanthanum cobalt oxides (La_1?x Sr _x CoO₃), have been investigated using X-ray photoelectron spectroscopy (XPS). Catalytic oxidations of both methane and CO have also been investigated using flow methods. The chemical composition of the surface of La_1?x Sr _x CoO₃ was very different from that in the bulk, which was measured by X-ray fluorescence spectroscopy (XRFS). The catalytic activity of La_1?x Sr _x CoO₃ increased with an increase in the quantity of cobalt atoms on the surface.     

Modeling of a power electronic converter for EMC in the conduction emission frequency band

With the advancement of high‐frequency switching devices, electromagnetic interferences (EMI) have become problems in power electronic converter designs. It is necessary for an electromagnetic compatibility (EMC) design to prospect and consider its possible EMI levels. This paper describes how to compute effects from a power converter to an object point to reduce conduction EMI noises effectively by an appropriate design. Modeling techniques for converter elements are discussed for a model in the conduction emission frequency band by the parameter tuning method and for line constants by an analytical derivation. Then a derived model is simulated for harmonic distributions of loop currents and their magnetic fields. © 2002 Scripta Technica, Electr Eng Jpn, 139(1): 44–50, 2002: DOI 10.1002/eej.1145     

Tradeoffs in granularity and parallelization for a Monte Carlo shower simulation code

The EGS4 code, developed at Stanford Linear Accelerator Center, simulates electron-photon cascading phenomena. The original code is inherently sequential: processing one particle at a time. This paper reports on a series of experiments in parallelizing different versions of EGS4. Our parallel experiments were run on a 30-processor Sequent Balance B21 and a 6-processor Symmetry S27. We have considered the following approaches for parallel execution of this application code:

1. (1) Original sequential version modified for parallel processing: 1 processor;

2. (2) Version 1 run multiprocessed: 1 to 29 processors;

3. (3) Sequential version modified for large-grain parallel processing: 1 procssor;

4. (4) Version 3 run using the Sequent Microtasking Library: 1 to 29 processors.

For each approach, we discuss the relative advantages and disadvantages in the areas of coding effort, understandability and portability, as well as performance, and outline a new parallelization approach we are currently pursuing based on Large-Grain Data Flow techniques.