A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Study of equivalent efficiency calibration method for radioactive gas source measured on HPGe detectors

ABSTRACT

In view of the complexity of current detection efficiency calibration of radioactive gas sources, a method using solid planar sources to be equivalent to gas sources was studied. For the 50 mL gas source box, an optimal equivalent scheme was selected by Monte Carlo Simulations. Then, the full-energy-peak efficiency curve of gas sources at the measurement position of 25 cm, with source-to-detector distance of 25 cm, was fitted by measuring solid planar sources with known activity. To verify the accuracy of the efficiency curve, ⁴¹Ar, ¹³³Xe and ⁸⁷Kr gases were produced and determined by length-compensated method. Then, their full-energy-peak efficiencies at 25 cm position away from the detector were directly calibrated. The percentage efficiency deviations between interpolation from the efficiency curve and direct calibration are all less than 2.5%, which proves the accuracy of the equivalent method. This calibration method is a general one and can be also used for some other radioactive sample measurements, such as non-destructive analysis of gaseous fission product samples with a suitable source-to-detector distance.     

煤炭城市环境承载力评估的探讨

本文综述了国内外环境承载力评估的进展及发展趋势，分析了城市环境承载力的特点及煤炭城市环境承载力评估的必要性，并对研究工作进行了展望。同时指出基于GIS的煤炭城市环境承载力评估是一个重要的研究方向，有待于多学科专家进一步探索、丰富和发展。     

光爆锚喷在苦竹林矿井施工中的应用研究

针对苦竹林矿井施工中的光爆锚喷情况进行了分析研究。     

矿业税费制度实证分析

在对矿产资源税费制度体系中存在问题分析的基础上，通过对安徽省煤炭行业税费负担的实证分析，提出了建立科学的矿产资源税费制度若干政策的建议。     

处理湿陷性黄土的方法在高速公路的应用

结合实际，介绍了几种湿陷性黄土的治理方法和应用情况。从处理效果和经济性综合分析比较了四种处理湿陷性黄土的主要措施。     

下分层综采工作面过本煤层上分层煤柱的开采实践

通过两个下分层工作面过本煤层上分层煤柱矿压显现分析，采取了3方面的措施，取得了良好的效果，为今后回采工作面过煤柱时积累了经验。     

扎哈·哈迪德:从图上到地上

15年来,一向以风格前卫著称的建筑师扎哈·哈迪德不断有作品建成。通过对这些作品的分析,以及对扎哈·哈迪德和扎哈·哈迪德事务所的工作习惯、表达方式、项目选择、组织方式等方面的探讨,如常用的设计词汇、工作软件、建筑师立场、城市地景观念等,结合扎哈·哈迪德的设计在从图纸走向建成的过程中的一些现象,来解析扎哈·哈迪德在不断探索建筑设计边界的实践中发生的转变。     

关于珠江边两块石头的对话——广州歌剧院设计深化访谈

关于广州歌剧院设计深化的访谈,讨论了从扎哈·哈迪德事务所的中标方案到施工图设计过程中的一些关键问题,包括中国设计师与扎哈·哈迪德事务所双方的设计合作、工作方式、重要修改、材料选择、结构与声学等技术支持、气候适应性、室内设计以及景观设计等方面,探讨了在深化过程中如何通过技术设计来表达最初的方案理念,以及可能会引起关注的技术细节,以实现这一造型特别、空间复杂的建筑。