T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis

To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43 microfilaremics, 12 symptomatic amicrofilaremics, and 52 elephantiasis patients. Lymphocyte proliferation was higher in elephantiasis patients and asymptomatic amicrofilaremics than in microfilaremics (P < .004). A proportion of asymptomatic amicrofilaremics (32%), elephantiasis patients (37%), and symptomatic amicrofilaremics (58%) showed antigen-specific lymphocyte unresponsiveness, and lymphocyte proliferation to filarial antigens correlated negatively with specific IgG4 levels (rho = -0.315, P < .001). As elevated specific IgG4 is an indicator of active infection, it is argued that active infection may result in lymphocyte hyporesponsiveness irrespective of clinical category. Of those with elevated specific IgE levels and high T cell proliferative responses, 70% had elephantiasis, suggesting these factors have a role in pathology. However, the existence of a proportion of elephantiasis patients with low anti-filarial IgE and T cell unresponsiveness to filarial antigens suggests that elephantiasis can be caused by distinct processes.     

QoS provisioning in cellular networks based on mobility prediction techniques

In cellular networks, QoS degradation or forced termination may occur when there are insufficient resources to accommodate handoff requests. One solution is to predict the trajectory of mobile terminals so as to perform resource reservations in advance. With the vision that future mobile devices are likely to be equipped with reasonably accurate positioning capability, we investigate how this new feature may be used for mobility predictions. We propose a mobility prediction technique that incorporates road topology information, and describe its use for dynamic resource reservation. Simulation results are presented to demonstrate the improvement in reservation efficiency compared with several other schemes.     

Endothelin-1 concentrations and optimisation of arterial oxygenation and venous admixture by selective pulmonary artery infusion of prostaglandin E1 during thoracotomy

PURPOSE: To demonstrate a superselective intraarterial chemotherapy as a therapeutic alternative in the treatment of previously treated recurrent lymph node metastases in breast cancer. METHODS: 14 patients with recurrent lymph node metastases in cases of breast cancer were presented to be treated by intraarterial chemotherapy of 25 mg mitoxantrone/m2 over a period of 24 hours. In two patients with superclavicular lymph node involvement an intraarterial therapy could not be carried out because of a vascular connection to the anterior spinal artery. Involved lymph stations could be reached in superselective technique by side branches of the subclavian artery. Heparin coverage was given intravenously. Every patient had had surgery, radiation, systemic chemo- and hormonal therapy before and was now graded as inoperable. Therapy indication was given by local tumour-induced symptoms. RESULTS: In the 12 treated cases complete remission was seen in three, partial remission in 4, a steady state in two and a progressive disease in three. There were no complications or severe side effects. CONCLUSION: Intraarterial chemotherapy is an effective and well tolerated treatment in recurrent lymph node metastases in cases of breast cancer even if conventional therapies can no longer be used.     

Characterization of zero locations of polytopes of real polynomials

Given a stability region of a polytope of polynomials, the edge theorem can be used to verify certain root-clustering properties of the polytope. The authors consider the inverse problem; starting with a polytope of real polynomials, they present a result that allows the construction of the smallest set of regions in the complex plane which characterizes its zero location     

Groups of algebraic integers used for coding QAM signals

Linear block codes over Gaussian integers and Eisenstein integers were used for coding over two-dimensional signal space. A group of Gaussian integers with 2²ⁿ elements was constructed to code quadrature amplitude modulation (QAM) signals such that a differentially coherent method can be applied to demodulate the QAM signals. This paper shows that one subgroup of the multiplicative group of units in the algebraic integer ring of any quadratic number field with unique factorization, modulo the ideal (Pⁿ), can be used to obtain a QAM signal space of 2p^2n-2 points, where p is any given odd prime number. Furthermore, one subgroup of the multiplicative group of units in the quotient ring Z[ω]/(pⁿ) can be used to obtain a QAM signal space of 6p^2n-2 points; one subgroup of the multiplicative group of units in the quotient ring Z[i](pⁿ) can be used to obtain a QAM signal space of 4p^2n-2 points which is symmetrical over the quadrants of the complex plane and useful for differentially coherent detection of QAM signals; the multiplicative group of units in the quotient ring Z[ω]/(2ⁿ) can be used to obtain a QAM signal space of 3·2^2n-2 points, where i=√-1, ω=(-1+√-3)/2=(-1+i√3)/2, p is any given odd prime number, Z[i] and Z[ω] are, respectively, the Gaussian integer ring and the Eisenstein integer ring. These multiplicative groups can also be used to construct block codes over Gaussian integers or Eisenstein integers which are able to correct some error patterns