A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

Input-to-state learning of recurrent neural networks with delay and disturbance

This article deals with the issue of input-to-state stabilization for recurrent neural networks with delay and external disturbance. The goal is to design a suitable weight-learning law to make the considered network input-to-state stable with a predefined -gain. Based on the solution of linear matrix inequalities, two schemes for the desired learning law are presented via using decay-rate-dependent and decay-rate-independent Lyapunov functionals, respectively. It is shown that, in the absence of external disturbance, the proposed learning law also guarantees the exponential stability of the network. To illustrate the applicability of the present weight-learning law, two numerical examples with simulations are given.     

Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C-C coupling reaction

Carbon-carbon (C-C) coupling reactions represent one of the most powerful tools for the synthesis of complex natural products, bioactive molecules developed as drugs and agrochemicals. In this work, a multifunctional nanoreactor for C-C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8 (Cu@Ni@ZIF-8). In this nanoreactor, Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center, and Cu core was in situ heating source for the catalyst by absorbing the visible light. Moreover, benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8, the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced. Most importantly, the microporous structure of ZIF-8 provided shape-selective of reactant. This composite was used for the highly shape-selective and stable photocatalysed C-C coupling reaction of boric acid under visible light irradiation. After five cycles, the nanoreactor still remained high catalytical activity. This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C-C coupling reactions with shape-selectivity.

     

三级连续碳化法生产纳米碳酸钙新工艺研究

采用有效容积依次递增的预塔、中塔、后塔三个碳化塔串联,塔内气液连续逆流操作、塔间气液连续并流或错流操作,严格控制氢氧化钙浆液的浓度、流量、温度和碳化气的浓度、流量,并通过pH计或电导仪进行跟踪检测碳化度,可实现纳米碳酸钙生产工艺连续化、产品质量稳定化、产量规模化.     

低应变配合静载测试在基桩检测中的应用

结合工程实例，论述了低应变检测配合静载测试的必要性及应注意的问题，着重介绍了对缺陷桩承载力的检测过程及分析思路。     

铜山铜矿床探采对比分析

选取铜山铜矿具有代表性的铜山矿段1号矿体、前山矿段4号矿体、前山南矿段30号矿体，将地质勘探资料与回采后地质资料所确定的矿体的形态、厚度、底板位移、资源储量等参数进行对比。分析了矿体勘、采资料误差的原因，探讨了合理的生产勘探方法及勘探网度，分析并划分了合理的勘探类型，为类似矿床的勘探、开发提供借鉴。     

动筛跳汰机及其应用

动筛跳汰机是近年来研制的用于分选25(13)~400mm粒级原煤的块煤分选设备,按驱动装置分为液压驱动式和机械驱动式两大类,处理量为50~350t/h,是目前国内选煤行业的最新产品之一。笔者认为,该设备在今后的煤炭洗选加工中具有广阔的应用和推广前景。     

煤炭企业发展循环经济的路径研究

我国煤炭企业传统的“大量生产、大量消费、大量废弃”的模式,存在着许多严重问题,如环境污染、煤炭资源的产出率低、利用率低、回收率低等。长此以往,煤炭企业将面临资源枯竭、无煤可采的局面,将无法满足我国经济又好又快的发展需求。因此,煤炭企业发展循环经济是大势所趋,势在必行。文章主要分析了煤炭企业发展循环经济的必要性,并对煤炭企业发展循环经济的路径问题进行了较深入地探讨。