Adding Support for Persistence to CLOS via Its Metaobject Protocol

Language-level support for object persistence frees programmers from having to confront a broad class of database issues from within their applications. By virtue of its metaobject protocol, CLOS is a language whose semantics can be tailored by individual programmers. We used the metaobject protocol to extend CLOS with support for object persistence. Our goal was to obtain a version of CLOS with persistence to which we could easily port a commercial geometric CAD modeling system. We describe the design and implementation of our persistence extension and highlight the strengths and weaknesses exhibited by the CLOS metaobject protocol during our experiment. For many aspects of the implementation we found that the metaobject protocol was ideal. In other cases we had to choose among paying a large performance penalty, extending the protocol, and bypassing the protocol by modifying the language implementation directly.     

Efficient wavefunction propagation by minimizing accumulated action

This paper presents a new technique to calculate the evolution of a quantum wavefunction in a chosen spatial basis by minimizing the accumulated action. Introduction of a finite temporal basis reduces the problem to a set of linear equations, while an appropriate choice of temporal basis set offers improved convergence relative to methods based on matrix exponentiation for a class of physically relevant problems.     

Prestressed Ceramic Coatings for Enhanced Reliability of Silicon Wafer Fracture Strength

The objective of this paper is to investigate thin, solid, prestressed ceramic films as a means of enhancing the reliability of silicon semiconductor wafers stressed in bending. To characterize the effect of thin films on strength, one-micrometer ceramic films were deposited on wafers using plasma-enhanced chemical-vapor deposition. The modulus of rupture (MOR) of the coated wafers was determined from four-point bend testing of coated samples. Adhesion testing of the coated wafers primarily showed cohesive rather than adhesive failure. A series of residual stresses was introduced into the coating-silicon interface and the MOR was determined. The results showed that for a thin brittle coating (1 mum) on a silicon wafer (635 mum), the minimal shear stress at the surface led to dominance of the residual stress over intrinsic coating strength as the critical parameter affecting failure. A correlation between MOR and residual stress was established.     

Amplification of Cerenkov Luminescence Using Semiconducting Polymers for Cancer Theranostics

The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Due to this limitation, Cerenkov luminescence (CL) from radionuclides has recently been proposed as an alternative light source in a strategy referred to as Cerenkov radiation-induced therapy (CRIT). Semiconducting polymer nanoparticles (SPNs) have ideal optical properties, such as large absorption cross-sections and broad absorbance, which can be utilized to harness the relatively weak CL produced by radionuclides. SPNs can be doped with photosensitizers and have ≈100% energy transfer efficiency by multiple energy transfer mechanisms. Herein, an optimized photosensitizer-doped SPN is investigated as a nanosystem to harness and amplify CL for cancer theranostics. It is found that semiconducting polymers significantly amplify CL energy transfer efficiency. Bimodal positron emission tomography (PET) and optical imaging studies show high tumor uptake and retention of the optimized SPNs when administered intravenously or intratumorally. Lastly, it is found that photosensitizer-doped SPNs have excellent potential as a cancer theranostics nanosystem in an in vivo tumor therapy study. This study shows that SPNs are ideally suited to harness and amplify CL for cancer theranostics, which may provide a significant advancement for CRIT that are unabated by tissue penetration limits.     

Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors

Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia-driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cells against solid tumors. However, efficacy of systemic oxygenation is limited against solid tumors outside of lungs and has been associated with unwanted side effects. As a result, it is essential to develop targeted oxygenation alternatives to weaken tumor hypoxia as novel approaches to restore immune responses against cancer. Herein, injectable oxygen-generating cryogels (O₂-cryogels) to reverse tumor-induced hypoxia are reported. These macroporous biomaterials are designed to locally deliver oxygen, inhibit the expression of hypoxia-inducible genes in hypoxic melanoma cells, and reduce the accumulation of immunosuppressive extracellular adenosine. The data show that O₂-cryogels enhance T cell-mediated secretion of cytotoxic proteins, restoring the killing ability of tumor-specific cytotoxic T lymphocytes, both in vitro and in vivo. In summary, O₂-cryogels provide a unique and safe platform to supply oxygen as a coadjuvant in hypoxic tumors and have the potential to improve cancer immunotherapies.     

Multi‐Material Tissue Engineering Scaffold with Hierarchical Pore Architecture

Multi‐material polymer scaffolds with multiscale pore architectures are characterized and tested with vascular and heart cells as part of a platform for replacing damaged heart muscle. Vascular and muscle scaffolds are constructed from a new material, poly(limonene thioether) (PLT32i), which meets the design criteria of slow biodegradability, elastomeric mechanical properties, and facile processing. The vascular–parenchymal interface is a poly(glycerol sebacate) (PGS) porous membrane that meets different criteria of rapid biodegradability, high oxygen permeance, and high porosity. A hierarchical architecture of primary (macroscale) and secondary (microscale) pores is created by casting the PLT32i prepolymer onto sintered spheres of poly(methyl methacrylate) (PMMA) within precisely patterned molds followed by photocuring, de‐molding, and leaching out the PMMA. Prefabricated polymer templates are cellularized, assembled, and perfused in order to engineer spatially organized, contractile heart tissue. Structural and functional analyses show that the primary pores guide heart cell alignment and enable robust perfusion while the secondary pores increase heart cell retention and reduce polymer volume fraction.     

Bidirectional Mobile Code Trust Management Using Tamper Resistant Hardware

Trust management in a networked environment consists of authentication and integrity checking. In a mobile computing environment, both remote hosts and mobile code are suspect. We present a model that addresses trust negotiation between the remote host and the mobile code simultaneously. Our model uses tamper resistant hardware, public key cryptography, and one-way hash functions.     

Characterization and Modeling of Laser Micromachined Periodically Corrugated Metallic Terahertz Wire Waveguides

Finite element method simulations of periodically corrugated metal terahertz wire waveguides have been conducted with concurrent analysis done on both the near-field confinement properties and the far-field emission properties at the end of the waveguides. This modeling was used to guide the choice of design parameters for the fabrication of waveguides with laser micromachining. The waveguides were characterized with a fiber-coupled terahertz time-domain spectroscopy and imaging system. The propagation properties as well as the frequency dependent diffraction at the end of the wire waveguides were examined and compared to straight, non-engineered metallic wire waveguides.     

Wavelet-based feature extraction from oceanographic images

Features in satellite images of the oceans often have weak edges. These images also have a significant amount of noise, which is either due to the clouds or atmospheric humidity. The presence of noise compounds the problems associated with the detection of features, as the use of any traditional noise removal technique will also result in the removal of weak edges. Recently, there have been rapid advances in image processing as a result of the development of the mathematical theory of wavelet transforms. This theory led to multifrequency channel decomposition of images, which further led to the evolution of important algorithms for the reconstruction of images at various resolutions from the decompositions. The possibility of analyzing images at various resolutions can be useful not only in the suppression of noise, but also in the detection of fine features and their classification. This paper presents a new computational scheme based on multiresolution decomposition for extracting the features of interest from the oceanographic images by suppressing the noise. The multiresolution analysis from the median presented by Starck-Murtagh-Bijaoui (1994) is used for the noise suppression     

Theoretical Modeling of Frequency-Chirped Optical Pulses in Birefringent Single-Mode Fibers

We analyze nonlinear coupling of polarized solitons in the presence of initial frequency chirp on the basis of a theoretical model described by a coupled nonlinear Schrödinger equations. We also obtain a threshold condition for the bound state of two polarizations and show analytically that the threshold amplitude for soliton trapping can be controlled by varying the chirp parameter.