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Grgoire B. Morand Isabel Cardona Sara Brito Silva Costa Cruz Alex M. Mlynarek Michael P. Hier Moulay A. Alaoui-Jamali Sabrina Daniela da Silva 《International journal of molecular sciences》2022,23(15)
The rise in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has prompted a quest for further understanding of the role of high-risk HPV in tumor initiation and progression. Patients with HPV-positive OPSCC (HPV+ OPSCC) have better prognoses than their HPV-negative counterparts; however, current therapeutic strategies for HPV+ OPSCC are overly aggressive and leave patients with life-long sequalae and poor quality of life. This highlights a need for customized treatment. Several clinical trials of treatment de-intensification to reduce acute and late toxicity without compromising efficacy have been conducted. This article reviews the differences and similarities in the pathogenesis and progression of HPV-related OPSCC compared to cervical cancer, with emphasis on the role of prophylactic and therapeutic vaccines as a potential de-intensification treatment strategy. Overall, the future development of novel and effective therapeutic agents for HPV-associated head and neck tumors promises to meet the challenges posed by this growing epidemic. 相似文献
3.
Investigation of Heat‐Induced Degradation of Virgin Olive Oil Using Front Face Fluorescence Spectroscopy and Chemometric Analysis 下载免费PDF全文
Yvon Mbesse Kongbonga Hassen Ghalila Youssef Majdi William Mbogning Feudjio Zohra Ben Lakhdar 《Journal of the American Oil Chemists' Society》2015,92(10):1399-1404
A simple setup using a 365‐nm light‐emitting diode coupled to a USB spectrometer through an optical fiber, in a front‐face fluorescence configuration, was used to investigate the heat‐induced deterioration of virgin olive oil at different heating temperatures and times. The samples were heated for 30, 60, 120 and 180 min for every temperature setting of 140, 160 and 180 °C, respectively. Two important results are reported in this article. First, a neo‐formed compound around 665 nm due to the degradation of chlorophyll was observed. This new peak was attributed to pyropheophytins. The second result showed an important rise of the peak around 489 nm, which corresponded to the oxidation products. The correlation obtained between the peroxide value and the 489 nm peak using principal component analysis revealed the mechanism of the oxidation process. It further showed that the peak around 489 nm is a direct consequence of the degradation of hydroperoxide. 相似文献
4.
Barkai Hassan El Abed Soumya Sadiki Moulay Iraqui Houssaini Mohammed 《The Journal of Adhesion》2016,92(5):341-348
The sessile drop technique was used to investigate the evolution of the physicochemical properties of cedar wood as a function of contact time with the Penicillium expansum spores. The most important finding showed that the impact of different contact periods (2, 4, 6, 8, 10, and 24 hr) on the wood surface were very indicative. In fact, after 2 hr of contact, the results have shown a significant impact of the bioadhesion of spores to the substrate on both the hydrophobic character (θW = 108.5°; ΔGiwi = ?28.25 mJ/m2), the electron donor (γ? = 13.63 mJ/m2), and the electron acceptor (γ+ = 4.35 mJ/m2) parameters that were significantly reduced compared to the initial wood (θW = 118.5°; ΔGiwi = ?6.29 mJ/m2; γ? = 32.1 mJ/m2; and γ+ = 9.1 mJ/m2). In addition, this decrease of parameters continued over time to stabilize after 10 hr of contact. Indeed, after 24 hr, the acid/base properties were almost zero and the contact angle with water decreased to 30°. Moreover, it was found that the coefficient of correlation (r2) was strong between the contact angle with water, the surface energy, and the electron acceptor character with the contact time parameter with values (r2 = 0.65), (r2 = 0.79), and (r2 = 0.68), respectively. 相似文献
5.
Ferhat Hamza Hammoudi Abderazek Smata Lakhdar Djeddou Ferhat Ali Rıza Yıldız 《The International Journal of Advanced Manufacturing Technology》2018,98(5-8):1267-1285
Selection of tooling to perform specific operations like drilling and milling on ceramic materials using rotary ultrasonic machining process is an important aspect to meet stringent dimensions on workpiece as well as intended performance of tool. This phenomenon is more critical for micro rotary ultrasonic machining. In the present study, an effort was made to do micro drilling operation of Ø0.3 mm tool with varying geometry, having different wall thicknesses and abrasive grain sizes using design of experiments. The effect of tool-based parameters like grain size and wall thickness has been studied on axial cutting force, radial cutting force, tool wear, edge chipping area and taper. After examining axial and radial cutting forces, it has been concluded that lower wall thickness (80 μm) tool is good for drilling operation; and higher wall thickness (100 μm) tool is good for milling operation under same material removal rate conditions. It has been also investigated that lower wall thickness (80 μm) tool has less edge chipping area and less taper and can impart high drilling depth as compared to higher wall thickness (100 and 150 μm) tool. It is also concluded that lesser grain size (15 μm) tools are advantageous in terms of edge chipping area and cutting force for drilling and milling operations as compared to higher grain size (30, 35 and 45 μm) tool at constant material removal rate. Higher grain size tools have been broken at 1.13 mm3/h material removal rate conditions due to bad profile accuracy. But higher grain size tools have worked fairly well at less material removal rate condition. Higher grain size tools produced less wear. Tool wear was found minimum in higher wall thickness (100 μm) tool having higher abrasive grain size (30 μm). Using inferred results, Ø0.3 mm drilling experiments have been carried out on six aerospace ceramic materials. Also, groove of 0.5 mm size using Ø0.3 mm optimised tool has been successfully carried out in sintered SiC. 相似文献
6.
The first objective of this paper investigates the influence of the previous strain history on ratcheting. New tests were performed where different strain-controlled histories have been applied prior to ratcheting tests. It is demonstrated that under the same conditions, one can observe ratcheting, plastic shakedown or elasticity according to the prior strain-controlled history. The second objective points out the correlation between the experimental data base devoted to the identification of the material parameters and the quality of the predictions in cyclic plasticity. The results suggest that the choice of the tests should be closely linked to the capabilities of the model. In particular, the presence of non proportional strain-controlled tests in the data base may be not a good choice if the model itself is not able to represent explicitly such a character. All tests considered here were performed on 304L SS at room temperature. 相似文献
7.
Vincent Léchappé Jesús De Léon Emmanuel Moulay Franck Plestan Alain Glumineau 《国际强度与非线性控制杂志
》2018,28(6):2356-2368
》2018,28(6):2356-2368
This paper deals with the problem of state and delay estimation for SISO nonlinear systems with an unknown time‐varying delay in the input. The main idea is to approximate the delayed input by using Taylor's theorem and to create an extended system with the delay as part of the extended state. Then, the construction of an observer is proposed to estimate both state and delay. The results are illustrated by simulations. 相似文献
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Lakhdar A Falleh H Ouni Y Oueslati S Debez A Ksouri R Abdelly C 《Journal of hazardous materials》2011,191(1-3):373-379
Organic wastes were successfully used as soil amendment to improve agrosystems productivity. Yet, the effectiveness of this practice to enhance plant antioxidant capacities has received little attention. Here, we assess the effect of municipal solid waste (MSW) compost (at 40 t ha(-1)) on growth, polyphenol contents and antioxidant activities of Mesembryanthemum edule. MSW compost application significantly increased the soil contents of carbon, nitrogen, calcium, phosphorus and potassium. This was associated with higher nutrient (N, P, and K) uptake, which likely led to the significant improvement of the plant biomass and relative growth rate (RGR) (+93% on average) as compared to the control. In the same way, the fertilizing effect of the added organic matter significantly enhanced the antioxidant potential M. edule, assessed by radical scavenging activity, iron reducing power and β-carotene bleaching capacity. This was associated with significantly higher antioxidant contents, mainly total phenols and flavonoids. Heavy metal (Pb, Cd, Cu, and Zn) concentrations were slightly increased upon compost application, but remained lower than phytotoxic values. Overall, our results point out that short-term MSW compost application at 40 t ha(-1) is efficient in enhancing the productivity together with the antioxidant potentiality of M. edule without any adverse environmental impact. 相似文献
10.
Christophe Lecoutre Lakhdar Saïs Sébastien Tabary Vincent Vidal 《Artificial Intelligence》2009,173(18):1592-1614
Constraint programming is a popular paradigm to deal with combinatorial problems in artificial intelligence. Backtracking algorithms, applied to constraint networks, are commonly used but suffer from thrashing, i.e. the fact of repeatedly exploring similar subtrees during search. An extensive literature has been devoted to prevent thrashing, often classified into look-ahead (constraint propagation and search heuristics) and look-back (intelligent backtracking and learning) approaches. In this paper, we present an original look-ahead approach that allows to guide backtrack search toward sources of conflicts and, as a side effect, to obtain a behavior similar to a backjumping technique. The principle is the following: after each conflict, the last assigned variable is selected in priority, so long as the constraint network cannot be made consistent. This allows us to find, following the current partial instantiation from the leaf to the root of the search tree, the culprit decision that prevents the last variable from being assigned. This way of reasoning can easily be grafted to many variations of backtracking algorithms and represents an original mechanism to reduce thrashing. Moreover, we show that this approach can be generalized so as to collect a (small) set of incompatible variables that are together responsible for the last conflict. Experiments over a wide range of benchmarks demonstrate the effectiveness of this approach in both constraint satisfaction and automated artificial intelligence planning. 相似文献