A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

An enhanced state estimation for linear parabolic PDE systems with mobile sensors

This paper studies an enhanced state estimation problem of distributed parameter processes modeled by a linear parabolic partial differential equation using mobile sensors. The proposed estimation scheme contains a state estimator and the guidance of mobile sensors, where the spatial domain is decomposed into multiple subdomains according to the number of sensors and each sensor is capable of moving within the respective subdomain. The state estimator is desired to make the state estimation error system exponentially stable while providing an performance bound. The mobile sensor guidance is used to enhance the transient performance of the error system. By the Lyapunov direct technique, an integrated design of state estimator and mobile sensor guidance laws is developed in the form of bilinear matrix inequalities (BMIs) to meet the desired design objectives. Moreover, to make the performance bound as small as possible, a suboptimal enhanced state estimation problem is formulated as a BMI optimization one, which can be solved via an iterative linear matrix inequality algorithm. Finally, numerical simulations are given to show the effectiveness of the proposed method.     

Improving fairness of TCP Vegas

TCP Vegas exhibits fairness problems even for flows with the same round‐trip time (RTT). We propose an enhanced Vegas with three revisions, replacing BaseRTT with RTT, detecting how fast acknowledgements return and the acceleration of the return speed. The impacts of each of the three proposed revisions are not ignorable. The proposed novel Vegas with the three revisions, called EVA, achieves better fairness under various network conditions. Copyright © 2004 John Wiley & Sons, Ltd.     

Repair of damaged aluminum truss joints of highway overhead sign structures using FRP

An innovative repair technique is introduced for aluminum truss-type highway overhead sign structures, using fibre-reinforced polymer (FRP) sheets. The welded k-joints are typically subjected to excessive fatigue-induced cracking under the effects of wind and moving traffic. The repair technique proposed in this paper utilizes longitudinal FRP layers bonded to the diagonals and wrapped around the main chord to form alternating v-patterns, followed by additional circumferential layers for anchorage. Eight tests were conducted on four full-scale specimens. Weld lines at the junction between diagonals and main chord were ground to simulate a 90% loss of joint strength. After repair, diagonals were loaded to failure in tension. The study showed that full strength of the welded joints was restored using carbon-FRP sheets. Only 70% of joint strength was restored when using glass-FRP. The strengthening technique is particularly sensitive to quality control during installation. A field application using the proposed technique was successfully completed by the New York State Department of Transportation for a cracked aluminum truss over Route 88 in NY State.     

On the shear strength of reinforced concrete deep beam with web opening

An objective of this study is to establish the shear strength of reinforced concrete deep beam with web opening. Eighteen beams were tested with the variables of the steel ratio and strength of longitudinal bars, concrete strength, and shear span‐to‐depth ratio. It was observed that the opening is strengthened by longitudinal bars but the load‐carrying capacity of deep beams with openings can be largely improved by the increase in concrete strength. Modifying the softened truss model derived by Mau and Hsu and utilizing the results of this experiment carried out with the variables of concrete strength, cross‐section size, shear‐span‐to‐depth ratio, and the strength and steel ratio of longitudinal bars, this study proposes an improved model to predict the shear strength. Copyright © 2006 John Wiley & Sons, Ltd.     

A fuzzy approach for the earned value management

The Earned Value technique is a crucial technique in analyzing and controlling the performance of a project which allows a more accurate measurement of both the performance and the progress of a project. This paper presents a new fuzzy-based earned value model with the advantage of developing and analyzing the earned value indices, and the time and the cost estimates at completion under uncertainty. As the uncertainty is inherent in real-life activities, the developed model is very useful in evaluating the progress of a project where uncertainty arises. A small example illustrates how the new model can be implemented in reality.     

A framework of critical resource chain for project schedule analysis

Analysing a schedule is beneficial to help stakeholders understand the scheduled project. Project schedules, which create time plans based on the critical path method (CPM) or on resource‐constrained project scheduling problem (RCPSP) optimization, are targets herein. The Theory of Constraints (TOC) treats a schedule as a system. Schedule elements are suspected constraints and a goal depends on the schedule creation policy. Resource information is further surveyed herein to identify true constraints. A framework is proposed to integrate identified constraints on a schedule, and the critical resource chain concept is introduced. Three scenarios illustrate the proposed framework under different scheduling considerations. Results explain schedule constraints, and several schedule analysis issues are discussed.