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排序方式: 共有102条查询结果,搜索用时 15 毫秒
1.
On the stability of solutions of autonomous index-I tractable and quasilinear index-2 tractable DAEs
Caren Tischendorf 《Circuits, Systems, and Signal Processing》1994,13(2-3):139-154
Conclusion We have seen that the stationary solutions of the regularized equations are asymptotically stable if the stationary solution of the original quasilinear index-2 tractable DAE is so. In other words, the given regularizations supply a solution sharing the stability properties of the solution of the unperturbed equation. 相似文献
2.
Francine Morris Ryan Vierling Lauren Boucher Prof. Jürgen Bosch Prof. Caren L. Freel Meyers 《Chembiochem : a European journal of chemical biology》2013,14(11):1309-1315
1‐Deoxy‐D ‐xylulose 5‐phosphate (DXP) synthase catalyzes the first step in the nonmammalian isoprenoid biosynthetic pathway to form DXP from pyruvate and D ‐glyceraldehyde 3‐phosphate (D ‐GAP) in a thiamin diphosphate‐dependent manner. Its unique structure and mechanism distinguish DXP synthase from its homologues and suggest that it should be pursued as an anti‐infective drug target. However, few reports describe any development of selective inhibitors of this enzyme. Here, we reveal that DXP synthase catalyzes C? N bond formation and exploit aromatic nitroso substrates as active site probes. Substrate specificity studies reveal a high affinity of DXP synthase for aromatic nitroso substrates compared to the related ThDP‐dependent enzyme pyruvate dehydrogenase (PDH). Results from inhibition and mutagenesis studies indicate that nitroso substrates bind to E. coli DXP synthase in a manner distinct from that of D ‐GAP. Our results suggest that the incorporation of aryl acceptor substrate mimics into unnatural bisubstrate analogues will impart selectivity to DXP synthase inhibitors. As a proof of concept, we show selective inhibition of DXP synthase by benzylacetylphosphonate (BnAP). 相似文献
3.
Mariia Belinskaia Tomas Zurawski Seshu Kumar Kaza Caren Antoniazzi J. Oliver Dolly Gary W. Lawrence 《International journal of molecular sciences》2022,23(2)
Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neurons from neonatal rat trigeminal ganglia—a locus for craniofacial sensory nerves—were used to examine how NGF affects the Ca2+-dependent release of a pain mediator, calcitonin gene-related peptide (CGRP), that is triggered by activating a key signal transducer, transient receptor potential vanilloid 1 (TRPV1) with capsaicin (CAP). Measurements utilised neurons fed with or deprived of NGF for 2 days. Acute re-introduction of NGF induced Ca2+-dependent CGRP exocytosis that was inhibited by botulinum neurotoxin type A (BoNT/A) or a chimera of/E and/A (/EA), which truncated SNAP-25 (synaptosomal-associated protein with Mr = 25 k) at distinct sites. NGF additionally caused a Ca2+-independent enhancement of the neuropeptide release evoked by low concentrations (<100 nM) of CAP, but only marginally increased the peak response to ≥100 nM. Notably, BoNT/A inhibited CGRP exocytosis evoked by low but not high CAP concentrations, whereas/EA effectively reduced responses up to 1 µM CAP and inhibited to a greater extent its enhancement by NGF. In addition to establishing that sensitisation of sensory neurons to CAP by NGF is dependent on SNARE-mediated membrane fusion, insights were gleaned into the differential ability of two regions in the C-terminus of SNAP-25 (181–197 and 198–206) to support CAP-evoked Ca2+-dependent exocytosis at different intensities of stimulation. 相似文献
4.
Ricardo Riaza Caren Tischendorf 《International Journal of Circuit Theory and Applications》2011,39(6):607-627
In this paper we present several semistate or differential‐algebraic models arising in nodal analysis of nonlinear circuits including memristors. The goal is to characterize the tractability index of these models under strict passivity assumptions, a key issue for the numerical simulation of circuit dynamics. We show that the main model, which combines memristors' fluxes and charges, is index two. From a technical point of view, this result is based on the use of a projector along the image of the leading matrix, in contrast to previous index analyses. For charge‐controlled memristors, the elimination of fluxes yields an index one system in topologically nondegenerate circuits, and an index two model otherwise. Analogous results are also proved to hold for flux‐controlled memristors. Our framework accommodates coupling effects among resistors, memristors, capacitors and inductors. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
5.
Various expert system development approaches were proposed but most of them cannot deal with two problems: the difficulty of analysis and maintenance. Rather than to spend time waiting any longer, it is better to find an alternative solution from other research fields. In computer software development area, researchers have been suffering from the difficulty of maintenance and analysis, just as the researchers in the expert system development field. To solve this issue, researchers in the software used both agile software development and business rules approach: agile software development is for overcoming the the difficulty of analysis, and business rules approach is for reducing issues in the maintenance. There is a big opportunity that those two approaches can also be solve the two issues in the expert system development field. The paper describes requirements of the approach based on agile software development and the business rules approach. As a result, we consider and specify why the Multiple Classification Ripple Down Rules is the novel approach for the expert system development. 相似文献
6.
7.
M. Bedenbecker R. Bandorf G. Bräuer H. Lüthje H. H. Gatzen 《Microsystem Technologies》2008,14(12):1949-1954
An important aspect of the development of electromagnetic microactuators is the search for suitable materials as well as the
development of the respective deposition and patterning processes. Within the Collaborative Research Center 516 “Design and
Fabrication of Active Microsystems”, it is the task of the subproject B1 “fabrication of magnetic thin films for electromagnetic
microactuators” to perform these investigations. The materials of interest can be divided into two groups: hard magnetic materials
and soft magnetic materials. Materials with optimized properties and fabrication processes have been developed within both
groups. An example is Samarium–Cobalt (SmCo), which can either be deposited using magnetron sputtering as Sm2Co17 with a very high energy product or in the SmCo5 phase using gas flow sputtering with very high deposition rates. In the area of soft magnetic materials, investigations on
Nickel-Iron (NiFe) especially NiFe81/19 were followed by the evaluation of NiFe45/55, which features a higher saturation flux
density B
s and relative permeability μ
r. Furthermore, current investigations focus on Cobalt-Iron (CoFe) and its further increased saturation flux density B
s and relative permeability μ
r. Current tasks include the stabilization of the fabrication processes to achieve good material properties (i.e. electroplating
of CoFe) or a shortening (e.g. by using heated substrates during deposition) by using process alternative not used so far.
Another topic is the integration into fabrication processes, i.e. the investigation of process stability and compatibility. 相似文献
8.
Norman Muenter Stephan Knappmann Caspar Morsbach Hans H. Gatzen 《Microsystem Technologies》2007,13(2):173-175
Flying heads carrying a magnetic coil and a high numerical aperture lens for magneto-optic recording or a solid immersion lens for optical phase change recording, respectively, are promising approaches for increasing the data density. A classic approach to dynamically evaluate the flight attitude of flying heads in data storage is acoustic emission (AE) testing of the head/disk interaction using special glide heads. In our paper we introduce the application of AE test heads for measuring the flying characteristics of optical far field and near field sliders. In comparison to conventional external AE sensors, i.e. sensors mounted somewhere in the drive, these AE elements are directly mounted on the sliders thus yielding a higher pulse shape and a better signal to noise ratio. This set-up allows a clear identification of the head disk contact. To calibrate the sensor a bump disk was fabricated and used for AE measurements. 相似文献
9.
Within the framework of the Collaborate Research Center Design and Fabrication of Active Microsystems (Sonderforschungsbereich 516), one aspect is the development of fabrication technology for driving coil systems to be applied to in electromagnetic microactuators. The two key focus areas are the fabrication of high aspect ratio conductors and insulating them by applying planarizing polymer material. The research activities included the development of technologies like for UV depth lithography, electroplating through lithographic masks (galvanoforming), as well as embedding in and planarization by insulation material. Combining these technologies allows to create high aspect ratio integrated multi-layer coils with integrated magnetic flux guiding structures. The materials applied were copper as a conductor, NiFe for magnetic cores and the negative tone resists SU-8 (MicroChem Corp.) as well as BCB (DOW Chemical) for insulation and embedding purposes. For electroplating molds, the DNQ/Novolak type photoresists AZ4562 and AZ9260 (Clariant) were utilized. The established technologies were integrated into process flows for fabricating thick and high aspect ratio planar and helical coils for electromagnetic linear actuators.This work was sponsored in part by the German Research Foundation as part of their support for the Collaborative Research Center Design and Fabrication of Active Microsystems. 相似文献
10.
Senliang Xi Xiaojun Wang Kudzaishe Caren Tome Tonghuan Zhang Zongying Han Meng Gao Shixue Zhou Hao Yu 《International Journal of Hydrogen Energy》2021,46(46):23748-23756
The hydrogen storage performances of MgH2 improved by the addition of Ni and SAPO-34 were studied in detail. The mixture of MgH2 with Ni and SAPO-34 was a physical reaction as shown by the X-ray diffraction (XRD) results. The SAPO-34 and Ni were uniformly distributed on the surface of MgH2. The thermodynamic and kinetic properties of 90MgH2/5Ni/5SAPO-34 were investigated by differential scanning calorimetry (DSC) and pressure-composition-isothermal (PCI) methods. The results showed that the dehydrogenation activation energy of 90MgH2/5Ni/5SAPO-34 decreased by 64.3 kJ/mol compared with that of MgH2. In addition, the relationship between the value of dehydrogenation heat and hydrogen content was also investigated by in-situ calorimetry. The enthalpy value of each sample in the dehydrogenation processes were calculated by in-situ calorimetry measurement. The dehydrogenation enthalpies of as-milled MgH2 and 90MgH2/5Ni/5SAPO-34 were 63.2 kJ/mol H2 and 53.6 kJ/mol H2, respectively. Thus, the co-doping of Ni and SAPO-34 contributed significantly to decrease the thermodynamic stability and improve the hydrogen sorption kinetic properties of MgH2. 相似文献