A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate the preparation process. These issues would be of less concern if the nanocarrier itself has most of the theranostic functions. In this work, a poly(ethylene glycol)‐boron dipyrromethene amphiphile (PEG‐F₅₄‐BODIPY) with 54 fluorine‐19 (¹⁹F) is synthesized and employed to emulsify perfluorohexane (PFH) into a theranostic nanoemulsion (PFH@PEG‐F₅₄‐BODIPY). The as‐prepared PFH@PEG‐F₅₄‐BODIPY can perform architecture‐dependent fluorescence/photoacoustic/¹⁹F magnetic resonance multimodal imaging, providing more information about the in vivo structure evolution of nanomedicine. Importantly, this nanoemulsion significantly enhances the therapeutic effect of BODIPY through both the high oxygen dissolving capability and less self‐quenching of BODIPY molecules. More interestingly, PFH@PEG‐F₅₄‐BODIPY shows high level of tumor accumulation and long tumor retention time, allowing a repeated light irradiation after a single‐dose intravenous injection. The “all‐in‐one” photodynamic theranostic nanoemulsion has simple composition, remarkable theranostic efficacy, and novel treatment pattern, and thus presents an intriguing avenue to developing clinically translatable theranostic agents.     

An enhanced state estimation for linear parabolic PDE systems with mobile sensors

This paper studies an enhanced state estimation problem of distributed parameter processes modeled by a linear parabolic partial differential equation using mobile sensors. The proposed estimation scheme contains a state estimator and the guidance of mobile sensors, where the spatial domain is decomposed into multiple subdomains according to the number of sensors and each sensor is capable of moving within the respective subdomain. The state estimator is desired to make the state estimation error system exponentially stable while providing an performance bound. The mobile sensor guidance is used to enhance the transient performance of the error system. By the Lyapunov direct technique, an integrated design of state estimator and mobile sensor guidance laws is developed in the form of bilinear matrix inequalities (BMIs) to meet the desired design objectives. Moreover, to make the performance bound as small as possible, a suboptimal enhanced state estimation problem is formulated as a BMI optimization one, which can be solved via an iterative linear matrix inequality algorithm. Finally, numerical simulations are given to show the effectiveness of the proposed method.     

Improving fairness of TCP Vegas

TCP Vegas exhibits fairness problems even for flows with the same round‐trip time (RTT). We propose an enhanced Vegas with three revisions, replacing BaseRTT with RTT, detecting how fast acknowledgements return and the acceleration of the return speed. The impacts of each of the three proposed revisions are not ignorable. The proposed novel Vegas with the three revisions, called EVA, achieves better fairness under various network conditions. Copyright © 2004 John Wiley & Sons, Ltd.     

Modeling investment priorities for national road improvements: A case study of Korea

The paper addresses specific problems associated with formulating investment priorities for national road improvements in Korea. More specifically, the objectives of the paper are (1) to present a model for formulating investment priorities for road improvements that may be useful to developing countries, (2) to test the model with simplified data for deriving investment priorities for Korea's road improvements, and (3) to learn lessons that can be applicable to other developing countries with particular respect to recommending investment priorities for road improvements. The study results are useful for planners, in developing countries, and also for evaluation analysts in funding institutions who are confronted with evaluating investment priorities for deteriorating road conditions.     

The relationship between physical and chemical weathering indices of granites around Seoul,Korea

In order to assess the relationship between chemical weathering indices and physical properties of granite, physical and chemical analyses were performed on both natural and artificially weathered granite samples from the Seoul area, where the pH of the rainfall occasionally drops to below 5. The results suggest that slake durability, uniaxial compressive strength, Ruxton ratio, Parker index, modified weathering potential index, chemical alteration index and loss on ignition effectively revealed changes of the degree of chemical weathering. However, the study showed no such good correlation between chemical and physical properties except dry density against loss on ignition and modified weathering potential index against uniaxial compressive strength. It is recommended that both physical and chemical indices should be used for the classification of weathering grade for the granites in the Seoul area.

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On the shear strength of reinforced concrete deep beam with web opening

An objective of this study is to establish the shear strength of reinforced concrete deep beam with web opening. Eighteen beams were tested with the variables of the steel ratio and strength of longitudinal bars, concrete strength, and shear span‐to‐depth ratio. It was observed that the opening is strengthened by longitudinal bars but the load‐carrying capacity of deep beams with openings can be largely improved by the increase in concrete strength. Modifying the softened truss model derived by Mau and Hsu and utilizing the results of this experiment carried out with the variables of concrete strength, cross‐section size, shear‐span‐to‐depth ratio, and the strength and steel ratio of longitudinal bars, this study proposes an improved model to predict the shear strength. Copyright © 2006 John Wiley & Sons, Ltd.     

想像与现实之间--草莓主题公园的空间和理念

在韩国,网络购物(InternetShopping)的环境非常发达。因此,在这种竞争之下,传统的售货柜台不仅要担负展陈商品的基本功能,而且开始更加重视营造消费场所给消费者带来的空间体验,以此提升柜台销售的竞争力。正是在这样的背景之下,SSAMZIE公司策划了“我喜欢草莓(Ilikedalki)”的     

Quantifying inequality in health in the absence of a natural reference group

When quantifying inequality in health, the excess fraction (i.e. the proportional reduction in the outcome in question that would occur if all groups had the same, lowest, risk rate) is an appealing measure. If the population contains a natural, healthiest reference group, the excess fraction is straightforward to estimate. In the absence of an a priori reference group, calculating the excess fraction requires reflection, since using the group with the lowest observed risk rate as reference can lead to erroneous conclusions. This paper proposes a simple simulation procedure for calculating the excess fraction, without fixing a reference group.     

基于静力弹塑性方法的混凝土框架结构的失效相关性分析

体系可靠度是衡量结构整体性能的一个重要指标。在体系可靠度的计算中,一个急待解决的问题是结构构件或截面间的失效相关性问题。基于静力弹塑性分析方法,对钢筋混凝土框架结构在小震和大震下进行了失效相关性研究。验证框架结构在小震下,梁约束的失效是统计独立的结论。在小震研究成果的基础上,对钢筋混凝土框架结构在大震情况下的失效相关性问题进行进一步研究,得出框架梁、柱在大震作用下的部分失效相关性规律。