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1.
We discuss some different ideas about the sort of formalism appropriate for translation (more specifically, transfer) that have been explored within Eurotra. The intention is not to evaluate these different ideas, but to outline the issues of general interest and relevance that they raise. Section 1 describes some common assumptions, section 2 describes the different ways they have been interpreted, and section 3 considers some further implications. 相似文献
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Miniaturizing experimental sample volumes to the nanoliter volume range is one of the most economical ways to perform mid- and high-throughput compound screening experiments. Existing automation platforms for nanoliter fluid handling can be bulky, expensive, and require periodic calibration to provide consistent liquid dispensing. In addition, even with frequent calibration, significant instrument-to-instrument variation in low-volume dispensing can occur between different instrument platforms. Many of these issues can be addressed by the use of PocketTips. PocketTips are tips with a defined internal pocket designed to hold specific nanoliter volumes of compound dissolved in dimethylsulfoxide. Although the overall liquid-handling process with PocketTips uses the aspirate/dispense features of the specific liquid-handling device being used, the dispensed nanoliter volume is solely based on the dimensions of the pocket of the PocketTip and thus, the liquid-handling device itself need not have nanoliter dispensing capabilities. In this report, we demonstrate the performance of PocketTips on different automation platforms. In addition, we used a cell-based ?-lactamase reporter assay system to demonstrate that compound delivery by PocketTips compares favorably with a standard compound addition technique. 相似文献
5.
Mark L. Darby Michael NikolaouJames Jones Doug Nicholson 《Journal of Process Control》2011,21(6):874-884
The practice of implementing real-time optimization (RTO) using a rigorous steady-state model, in conjunction with model predictive control (MPC), dates back to the late 1980s. Since then, numerous projects have been implemented in refinery and chemical plants, and RTO has received significant attention in the industrial and academic literature. This history affords us the opportunity to assess the impact and success of RTO technology in the process industries. We begin with a discussion of the role RTO serves in the hierarchy of control and optimization decision making in the plant, and outline the key steps of the RTO layer and the coordination with MPC. Where appropriate, we point out the different approaches that have been used in practice and discuss the success factors that directly relate to the success of RTO within an organization. We also discuss alternative approaches that have been used to alleviate some of the challenges associated with implementing RTO and which may be appropriate for those unwilling to commit to the traditional RTO approach. Lastly, we provide suggestions for improvement to motivate further research. 相似文献
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Minhong Wang Huaiqing Wang Doug Vogel Kuldeep Kumar Dickson K.W. Chiu 《Engineering Applications of Artificial Intelligence》2009,22(7):1046-1055
Modern businesses are facing the challenge of effectively coordinating their supply chains from upstream to downstream services. It is a complex problem to search, schedule, and coordinate a set of services from a large number of service resources under various constraints and uncertainties. Existing approaches to this problem have relied on complete information regarding service requirements and resources, without adequately addressing the dynamics and uncertainties of the environments. The real-world situations are complicated as a result of ambiguity in the requirements of the services, the uncertainty of solutions from service providers, and the interdependencies among the services to be composed. This paper investigates the complexity of supply chain formation and proposes an agent-mediated coordination approach. Each agent works as a broker for each service type, dedicated to selecting solutions for each service as well as interacting with other agents in refining the decision making to achieve compatibility among the solutions. The coordination among agents concerns decision making at strategic, tactical, and operational level. At the strategic level, agents communicate and negotiate for supply chain formation; at the tactical level, argumentation is used by agents to communicate and understand the preferences and constraints of each other; at the operational level, different strategies are used for selecting the preferences. Based on this approach, a prototype has been implemented with simulated experiments highlighting the effectiveness of the approach. 相似文献
8.
The use of information technology to enhance teaching and learning processes has been practiced for a number of years now.
However, the rapid growth in the use of the Internet has led to a new dimension in interactive and collaborative learning
anytime and anyplace dynamically. With the explosion of “virtual education initiatives”, the question of the feasibility and
success criteria for such projects quickly arises. To address the question in an organized way, we propose a project assessment
based on critical success factors. Hence, in this article, we draw on a widely recognized critical success factor framework.
We (slightly) adjust the framework to fit the special characteristics of virtual education initiatives, and apply to one case
study, namely the virtual education initiative at the Faculty of Business at the City University of Hong Kong. The results
suggest that the past success of the case is due to the adherence to the large majority of critical success factors. However,
it also outlines some areas of concern. The paper concludes with a discussion on the strength and limitations of virtual learning
environment as well as future directions.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
9.
分辨率增强技术(RET)设计流程中聚集了各式各样的点工具和方法。当前对深亚波长可制造性(DFM)设计的要求迫使设计与制造行业必须建立十分密切的合作关系。同时也促使EDA行业提供一种平台,以促进这些行业间的密切交流。合理利用这一平台将会对产能和品质产生直接的影响。 相似文献
10.
Doug Williams Marian F. Ursu Joshan Meenowa Pablo Cesar Ian Kegel Karl Bergström 《Telematics and Informatics》2011
This paper discusses results from research related to the use of television as a device that supports social interaction between close-knit groups in settings that include more than two locations, each location being potentially equipped with more than one camera. The paper introduces the notion of a framing experience, as a specific scenario or situation within which social communication takes place. It reports on the evaluation of some of the key attributes of social communication through semi-structured interviews, with 16 families across four European countries. The inferences drawn from this study are reduced to four system capabilities including the ability to support: excitement, engagement and entertainment; high quality, reliable audiovisual communications; flexibility and adaptability sufficient to support the unpredictable and reactive nature of human interaction and discourse. These system requirements are, in turn, reduced to a number of technology challenges which if solved will help enable effective social communications between groups, mediated by the television. These technology challenges include: high quality reliable audio visual communication; interaction orchestration, multimedia interpretation and multimedia composition. Finally the paper reflects on the impact the use of framing experiences, such as those described here, could have on strategy and policy for service providers and regulators. 相似文献