Drug Release from Lipogels According to Gelling Conditions and Mechanical Treatment

The release rate of a drug dissolved in the liquid phase of lipogels may be greatly affected by the type and concentration of gelling agent and by processing conditions and mechanical treatment of the ointment. These differences in release rate are reduced after application of mechanical stress comparable with the strain exerted on the ointment during application to the skin. Therefore, changes in the concentration of gelling agents used to achieve suitable consistency and manufacturing and packing processes that meet industrial and marketing requirements do not appear to exert a practical influence on drug availability after application to the skin.     

Environmentally friendly, heterogeneous acid and base catalysis for the methylation of catechol: Chances for the control of chemo-selectivity

The properties of catalysts with (i) Brønsted-type acidity (H-mordenite and Al/P mixed oxide), (ii) Lewis-type acidity (Al trifluoride) or (iii) basic characteristics (Mg/Fe mixed oxide) were investigated in the gas-phase methylation of catechol. When methanol was used as the methylating agent, H-mordenite and AlF₃ gave high selectivities to guaiacol (the product of O-methylation) under mild reaction conditions, that is at very low catechol conversions. An increase in temperature led to the transformation of guaiacol to phenol and cresols, and to considerable catalyst deactivation. The basic catalyst Mg/Fe/O also favored an extensive degradation of guaiacol to phenol. On the mildly acidic catalyst Al/P mixed oxide a stable catalytic performance and a high selectivity to guaiacol at 40% catechol conversion were obtained. When methylformate, a more reactive methylating agent, was used with AlF₃ and Mg/Fe mixed oxide as catalysts, higher catechol conversions and slower deactivation rates could be achieved under mild reaction conditions, with a low extent of guaiacol degradation. However, methylformate rapidly decomposed when temperatures above 350 °C were used. Finally, tests were made by reacting catechol and diethoxymethane with acid catalysts, with the aim of synthesizing methylenedioxybenzene. The latter product was obtained with high selectivity, but with very low yield, due to both catalyst deactivation and decomposition of diethoxymethane.     

Effects of CSCW on organizations

We consider the potential impact of Computer Supported Cooperative Work, with special reference to large technically advanced projects involving several organizations. It is vital that such projects are managed efficiently, without delays, since a product that reaches the market a few months earlier than its competitors enjoys a great advantage. Traditional methods of coordinating large projects, based on hierarchical communication, tend to produce delays, since technicians at remote sites are obliged to solve coordination problems by passing them up the hierachy. It would be better if such problems were solved by improvising conferences among the technicians; Computer Supported Cooperative Work will provide the technical means of implementing this heterarchical style of management without losing control of the project. The use of computers as a social medium raises methodological and ethical issues which are discussed in the final section.     

A Semantic Proof of Polytime Soundness of Light Affine Logic

We define realizability semantics for Light Affine Logic ( LAL\mathsf{LAL} ) which has the property that denotations of functions are polynomial time computable by construction of the model. This gives a new proof of polytime-soundness of LAL\mathsf{LAL} which is considerably simpler than the standard proof based on proof nets and is entirely semantical in nature. The model construction uses a new instance of a resource monoid; a general method for interpreting systems based on Linear Logic introduced earlier by the authors.     

Illustrating volume data sets and layered models with importance-aware composition

Non-photorealistic (illustrative) rendering augments typical rendering models to selectively emphasize or de-emphasize specific structures of rendered objects. Illustrative techniques may affect not only the rendering style of specific portions of an object but also their visibility, ensuring that less important regions do not occlude more important ones. Cutaway views completely remove occluding, unimportant structures—possibly also removing valuable context information—while existing solutions for smooth reduction of occlusion based on importance lack precise visibility control, simplicity and generality. We introduce a new front-to-back fragment composition equation that directly takes into account a measure of sample importance and allows smooth and precise importance-based visibility control. We demonstrate the generality of our composition equation with several illustrative effects, which were obtained by using a set of importance measures calculated on the fly or defined by the user. The presented composition method is suitable for direct volume rendering as well as rendering of layered 3D models. We discuss both cases and show examples, though focusing mainly on illustration of volumetric data.     

Realizability models and implicit complexity

New, simple, proofs of soundness (every representable function lies in a given complexity class) for Elementary Affine Logic, LFPL and Soft Affine Logic are presented. The proofs are obtained by instantiating a semantic framework previously introduced by the authors and based on an innovative modification of realizability. The proof is a notable simplification on the original already semantic proof of soundness for the above mentioned logical systems and programming languages. A new result made possible by the semantic framework is the addition of polymorphism and a modality to LFPL, thus allowing for an internal definition of inductive datatypes. The methodology presented proceeds by assigning both abstract resource bounds in the form of elements from a resource monoid and resource-bounded computations to proofs (respectively, programs).     

Neutrophils Mediate Pulmonary Artery Thrombosis In Situ

Pulmonary embolism is a life-threatening condition, which can result in respiratory insufficiency and death. Blood clots occluding branches of the pulmonary artery (PA) are traditionally considered to originate from thrombi in deep veins (usually in legs). However, growing evidence suggests that occlusion of the vessels in the lungs can develop without preceding deep vein thrombosis (DVT). In this work, we used an inferior vena cava (IVC) complete ligation model of DVT in Wistar rats to explore the possibility and mechanisms of PA thrombosis under the conditions where all routes of thrombotic mass migration from peripheral veins are blocked. We demonstrate that rats both with normal and reduced neutrophil counts developed thrombi in the IVC, although, neutropenia caused a substantial decrease in thrombus size and a shift from fresh fibrin toward mature fibrin and connective tissue inside the thrombus. Massive fibrin deposition was found in the PA branches in the majority of DVT rats with normal neutrophil counts, but in none of the neutropenic animals. Neutrophil ablation also abolished macroscopic signs of lung damage. Altogether, the results demonstrate that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the DVT setting.     

State-of-the-Art on Wound Vitality Evaluation: A Systematic Review

The vitality demonstration refers to determining if an injury has been caused ante- or post-mortem, while wound age means to evaluate how long a subject has survived after the infliction of an injury. Histology alone is not enough to prove the vitality of a lesion. Recently, immunohistochemistry, biochemistry, and molecular biology have been introduced in the field of lesions vitality and age demonstration. The study was conducted according to the preferred reporting items for systematic review (PRISMA) protocol. The search terms were “wound”, “lesion”, “vitality”, “evaluation”, “immunohistochemistry”, “proteins”, “electrolytes”, “mRNAs”, and “miRNAs” in the title, abstract, and keywords. This evaluation left 137 scientific papers. This review aimed to collect all the knowledge on vital wound demonstration and provide a temporal distribution of the methods currently available, in order to determine the age of lesions, thus helping forensic pathologists in finding a way through the tangled jungle of wound vitality evaluation.