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AV Demin AV Kolesnikov MA Olfer'ev PV Favorov KV Fegeding AG Gabibov NV Gnuchev 《Canadian Metallurgical Quarterly》1998,34(10):1333-1337
A new system for the expression of a catalytic light chain antibody to the vasoactive intestinal peptide is described. The system made possible the isolation the large amounts of a homogeneous protein without any additional peptide domains. The preparation obtained can be used in further experiments on light chain crystallization and in X-ray-structural analysis of its catalytic center. 相似文献
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Method of calculating forces in buildings subject to bed deformations induced by underground excavations 总被引:1,自引:0,他引:1
A. N. Pushilin A. V. Favorov V. I. Sheinin 《Soil Mechanics and Foundation Engineering》2007,44(3):77-82
Basic positions of a procedure for calculating forces in buildings subject to bed deformation induced by underground excavations
are presented with, among other things, consideration of the shear stiffness of the building modeled. Examples of calculations
are cited for specific structure and bed parameters with the underground excavation residing at different depths. The significance
of accounting for the shear stiffness of the structure is established when evaluating the deformations and forces. The potential
for use of the method is addressed for the solution of other geotechnical problems.
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Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 3, pp. 2–6, May–June, 2007. 相似文献
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V. I. Sheinin E. P. Sarana S. A. Artemov A. V. Favorov 《Soil Mechanics and Foundation Engineering》2006,43(5):153-160
An algorithm is proposed for practical implementation of a scheme for analysis of the settlement of building foundations,
which has been set forth in modern regulatory documents. Methods to account for a slab with a complex planform, nonuniform
loading on the bed, and the actual heterogeneity of the soil bed, which can be assigned directly from survey data, are developed
within the framework of this scheme.
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Translated from Osnovaniya, Fundamenty i Mekhanika Gruntov, No. 5, pp. 2–7, September–October, 2006. 相似文献
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The measurements of intensity of infrared radiation from the surface of rock sample under nonstationary change in stress state are described. The synchronized records of alterations in axial stress of sample under the uniaxial compression and the corresponding time variations in the intensity of infrared radiation from the sample surface are obtained. It is shown that identification of the parameters of elastic oscillations under the action of nonstationary load is reliable. 相似文献
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M Tommerdahl KA Delemos OV Favorov CB Metz CJ Vierck BL Whitsel 《Canadian Metallurgical Quarterly》1998,80(6):3272-3283
Response of anterior parietal cortex to different modes of same-site skin stimulation. J. Neurophysiol. 80: 3272-3283, 1998. Intrinsic optical signal (IOS) imaging was used to study responses of the anterior parietal cortical hindlimb region (1 subject) and forelimb region (3 subjects) to repetitive skin stimulation. Subjects were four squirrel monkeys anesthetized with a halothane/nitrous oxide/oxygen gas mixtures. Cutaneous flutter of 25 Hz evoked a reflectance decrease in the sectors of cytoarchitectonic areas 3b and/or 1 that receive input from the stimulated skin site. The intrinsic signal evoked by 25-Hz flutter attained maximal intensity =2.5-3.5 s after stimulus onset, remained well maintained as long as stimulation was continued, and disappeared rapidly (usually =2-5 s) after stimulus termination. Repetitive skin heating stimuli were delivered via a probe/thermode in stationary contact with the skin (6 temperature ramps/trial; within-trial ramp frequency 0.42 Hz; intertrial interval 180 s; initial temperature 32-36 degreesC; maximal temperature 48-52 degreesC; rate of temperature change 19 degreesC/s). Skin heating led to a large-amplitude reflectance decrease within a zone of area 3a, which neighbored the region in areas 3b/1 that emitted an intrinsic signal in response to same-site 25-Hz flutter in the same subject. In three of four subjects a lower-amplitude decrease in reflectance also occurred in a region of area 4 continuous with the area 3a region that responded maximally to same-site skin heating. The reflectance decrease evoked in areas 3a/4 by skin heating consistently exceeded in both intensity and spatial extent the decrease in reflectance evoked in areas 3b/1 by same-site 25-Hz cutaneous flutter. These findings are viewed as consistent with the proposal that area 3a plays a leading role in the anterior parietal cortical processing of the afferent drive evoked by skin-heating stimuli perceived as painful. In all four subjects the reflectance decrease evoked in areas 3a/4 by skin heating was accompanied by a simultaneous but opposite change in reflectance (a reflectance increase) within a large territory located immediately posterior to the regions that responded with a decrease in reflectance-an observation that raised the possibility that skin heating evoked opposing influences on the activity of area 3a and 3b/1 regions that receive input from the stimulated skin site. This was evaluated with the method of correlation mapping. The observations obtained with correlation mapping appear consistent with demonstrations by others that skin-heating stimuli perceived as painful by conscious subjects suppress/inhibit the anterior parietal response to innocuous mechanical skin stimulation. The opposing (relative to the response of area 3a) optical response of area 1 and/or area 3b during skin heating stimulation is attributed to suppression/inhibition of area 1 and/or area 3b neuron activity. 相似文献
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V. I. Sheinin E. A. Motovilov A. A. Morozov A. V. Favorov 《Journal of Mining Science》1999,35(6):602-607
The efficiency of infrared radiometry as a source of information on changes in the stress state of rocks is substantiated
experimentally. The experiments were conducted under conditions of pulse actions. An analysis of synchronized records of the
mechanical state of the specimen and the corresponding variations in the intensity of heat flux from its surface shows the
reliability of recording and evaluating “jumps” in stresses on the basis of radiometric data.
The Gersevanov Scientific-Research Institute of Foundations and Underground Structures, Moscow. Translated from Fiziko-Tekhnicheskie
Problemy Razrabotki Poleznykh Iskopaemykh, No. 6, pp. 48–53, November–December, 1999. 相似文献
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Modern science is turning to progressively more complex and data-rich subjects, which challenges the existing methods of data
analysis and interpretation. Consequently, there is a pressing need for development of ever more powerful methods of extracting
order from complex data and for automation of all steps of the scientific process. Virtual Scientist is a set of computational procedures that automate the method of inductive inference to derive a theory from observational
data dominated by nonlinear regularities. The procedures utilize SINBAD – a novel computational method of nonlinear factor
analysis that is based on the principle of maximization of mutual information among non-overlapping sources, yielding higher-order
features of the data that reveal hidden causal factors controlling the observed phenomena. The procedures build a theory of
the studied subject by finding inferentially useful hidden factors, learning interdependencies among its variables, reconstructing
its functional organization, and describing it by a concise graph of inferential relations among its variables. The graph
is a quantitative model of the studied subject, capable of performing elaborate deductive inferences and explaining behaviors
of the observed variables by behaviors of other such variables and discovered hidden factors. The set of Virtual Scientist procedures is a powerful analytical and theory-building tool designed to be used in research of complex scientific problems
characterized by multivariate and nonlinear relations.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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