Lower down both ohmic and cathode polarization resistances of solid oxide fuel cell via hydrothermal modified gadolinia doped ceria barrier layer

Hydrothermal reaction in Cerium and Gadolinium solution as an optimization method is developed and first reported for the densification of gadolinia doped ceria, the barrier layer between Zirconia electrolyte and (La,Sr)(Co,Fe)O_3-δ cathode. This method is based on the hydrothermal reaction for nano particles in-situly grown on porous surface, to improve barrier layer density, alongside the sintering of cathode at 1075 °C. As a result, the ohmic resistance is prominently decreased by ～16.4 % at 750 °C for electrolyte supported symmetrical cell. Whereas, the cathode polarization resistance is decreased by as much as a factor of ～3 from 0.3702 Ω·cm² to 0.1325 Ω·cm² at 750 °C and $p_{O_2}=0.21atm$. Furthermore, the anode supported cell exhibits higher open circuit voltage, smaller area specific resistance, elevated performance output and less degradation. And this modified barrier layer shows reduced Sr migration in 300 h operation at 750 °C. The hydrothermal reaction is demonstrated to prepare denser and sintering-active barrier layer with faster oxygen ion transfer and better interface connection, with large-scale application prospects and cost-competitiveness.     

随机振动激励法的应用——测定高灵敏度传感器横向振动特性

本文提出了一种评定传感器技术指标的较好的方法。此方法较之以往采用的正弦或正弦扫频激励法具有明显的优点,可以满足传感器生产现场的需要。本文最后给出了实例。     

冻土地区桥梁基础施工

针对冻土地区天气寒冷、冰冻期长的特点,介绍了冻结法施工,探讨了其施工的主要条件、方法及注意事项,并对冻土地区桥梁基础施工进行了详细介绍,提出了提高混凝土抗冻融耐久性的措施,提高了基坑的施工速度,缩短了铁路修建的工期,减少了基坑的事故率。     

提高高温差地区40 m曲线箱梁外观质量一次合格率

混凝土构造物中出现外观质量问题是混凝土施工过程中最为常见的质量通病。在较为恶劣的施工环境下提高外观质量合格率这一问题不仅具有现实意义,同时对今后西部地区的类似工程施工也具有促进作用。     

Biocompatible electrospun tactic poly(methyl methacrylate) blend fibers

Uniform and beads free fibers of pristine syndiotactic PMMA (s-PMMA), isotactic PMMA (i-PMMA), and their blends in the ratio of s:i = 3:1, 1:1 and 1:3 were successfully prepared using the electrospinning technique. The tactic PMMA blend fibers showed unique thermal stability and glass transition temperatures compared to their pristine counterparts. An interesting endotherm peak was observed for the s:i = 1:3 electrospun fibers, which might indicate a complex formation between the two tactic PMMAs. Systematic surface functionalities study by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) revealed the interactions between these two tactic PMMAs. Biocompatibility of tactic PMMA and their blend fibers was first time comparably investigated using HeLa as the model mammalian cell line; an intriguing observance was first revealed that the blend fibers showed better biocompatibility than both pristine ones, though the behind mechanism is not well understood yet.     

考虑土分层的搅拌桩支护结构性能研究

将水泥土搅拌桩支护结构及土体视为共同变形的整体,建立了三维有限元模型,选用Drucker-Prager本构模型及非线性增量迭代法,以泉州某基坑为工程原型,利用ANSYS工程计算软件,进行了模型验证,并详细讨论了各支护参数变化时水泥土搅拌桩的位移、应力分布。揭示了地面堆载、墙体厚度、不同土层性质及其分布对搅拌桩位移、应力的影响,墙体位移和应力的关系,分步开挖对搅拌桩位移的影响及合理布置开挖步需考虑的因素。     

Comparison of the Chemical Components,Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses

To clarify the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs of similar origin, an integrated strategy of network pharmacology, molecular pharmacology, and metabolomics was employed, with a view to investigating the commonalities and dissimilarities in chemical components, efficacy and mechanisms of action. Initial HPLC-Q-TOF-MS analysis revealed that CMF and CIF had different flavonoid constituents. The biological processes underlying the therapeutic effects of CMF and CIF on liver-fire hyperactivity syndrome of hypertension (LFHSH) were predicted to be related to inflammatory response, fatty acid production, and other pathways based on network pharmacology analysis. ELISA, molecular docking, Western blot, and metabolomics techniques showed similar effects of CMF and CIF in lowering blood pressure, resistance to tissue, organ and functional damage, and dyslipidemia. However, distinct effects were found in the regulation of inflammatory response, PI3K-Akt and NF-κB signaling pathways, lipid anabolism, renin-angiotensin system, and metabolic abnormalities. The comparable efficacies of CMF and CIF, despite having distinct mechanisms of action, may be attributed to the integration and counteraction of their different regulating capabilities on the above anti-LFHSH mechanisms. This study offers a vital platform for assessment of differential and precise applications of herbs of close origin with similar but slightly different medicinal properties, and provides a research strategy for bridging Chinese medicine and modern precision medicine.     

Treatment of Periodontal Inflammation in Diabetic Rats with IL-1ra Thermosensitive Hydrogel

Periodontitis is a chronic inflammatory disease that is considered to be the main cause of adult tooth loss. Diabetes mellitus (DM) has a bidirectional relationship with periodontitis. Interleukin-1β (IL-1β) is an important pre-inflammatory factor, which participates in the pathophysiological process of periodontitis and diabetes. The interleukin-1 receptor antagonist (IL-1ra) is a natural inhibitor of IL-1, and the balance between IL-1ra and IL-1β is one of the main factors affecting chronic periodontitis (CP) and diabetes. The purpose of this study is to develop a drug carrier that is safe and nontoxic and can effectively release IL-1ra, which can effectively slow down the inflammation of periodontal tissues with diabetes, and explore the possibility of lowering the blood sugar of this drug carrier. Therefore, in this experiment, a temperature-sensitive hydrogel loaded with IL-1ra was prepared and characterized, and its anti-inflammatory effect in high-sugar environments in vivo and in vitro was evaluated. The results showed that the hydrogel could gel after 5 min at 37 °C, the pore size was 5–70 μm, and the cumulative release of IL-1ra reached 83.23% on the 21st day. Real-time polymerase chain reaction (qRT-PCR) showed that the expression of IL-1β, Interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) inflammatory factors decreased after the treatment with IL-1ra-loaded thermosensitive hydrogel. Histological evaluation and micro-computed tomography (Micro-CT) showed that IL-1ra-loaded thermosensitive hydrogel could effectively inhibit periodontal inflammation and reduce alveolar bone absorption in rats with diabetic periodontitis. It is worth mentioning that this hydrogel also plays a role in relieving hyperglycemia. Therefore, the temperature-sensitive hydrogel loaded with IL-1ra may be an effective method to treat periodontitis with diabetes.     

Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress,Autophagy, Apoptosis,and Fibrosis

Cadmium (Cd) is a potential pathogenic factor in the urinary system that is associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm in diameter, are a major carrier of contaminants. We applied 10 mg/L particle 5 μm MPs and 50 mg/L CdCl2 in water for three months in vivo assay to assess the damaging effects of MPs and Cd exposure on the kidney. In vivo tests showed that MPs exacerbated Cd-induced kidney injury. In addition, the involvement of oxidative stress, autophagy, apoptosis, and fibrosis in the damaging effects of MPs and Cd on mouse kidneys were investigated. The results showed that MPs aggravated Cd-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis. These findings provide new insights into the toxic effects of MPs on the mouse kidney.