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This paper studies a new class of single-machine scheduling problems, which are faced by Just-in-Time-suppliers satisfying a given demand. In these models the processing of jobs leads to a release of a predefined number of product units into inventory. Consumption is triggered by predetermined time-varying, and product-specific demand requests. While all demands have to be fulfilled, the objective is to minimize the resulting product inventory. We investigate different subproblems of this general setting with regard to their computational complexity. For more restricted problem versions strongly polynomial time algorithms are presented. In contrast to this, NP-hardness in the strong sense is proven for more general problem versions. Moreover, for the most general version, even finding a feasible solution is shown to be strongly NP-hard. 相似文献
3.
Malte Krack Marc Secanell Pierre Mertiny 《Structural and Multidisciplinary Optimization》2011,44(1):57-73
A procedure to find the optimal design of a flywheel with a split-type hub is presented. Since cost plays a decisive role
in stationary flywheel energy storage applications, a trade-off between energy and cost is required. Applying a scaling technique,
the multi-objective design problem is reduced to the maximization of the energy-per-cost ratio as the single objective. Both
an analytical and a finite element model were studied. The latter was found to be more than three orders of magnitude more
computationally expensive than the analytical model, while the analytical model can only be regarded as a coarse approximation.
Multifidelity approaches were examined to reduce the computational expense while retaining the high accuracy and large modeling
depth of the finite element model. Using a surrogate-based optimization strategy, the computational cost was reduced to only
one third in comparison to using only the finite element model. A nonlinear interior-point method was employed to find the
optimal rim thicknesses and rotational speed. The benefits of the split-type hub architecture were demonstrated. 相似文献
4.
Jens Lincke Malte Appeltauer Bastian Steinert Robert Hirschfeld 《Science of Computer Programming》2011,76(12):1194-1209
Context-oriented programming (COP) provides dedicated support for defining and composing variations to a basic program behavior. A variation, which is defined within a layer, can be de-/activated for the dynamic extent of a code block. While this mechanism allows for control flow-specific scoping, expressing behavior adaptations can demand alternative scopes. For instance, adaptations can depend on dynamic object structure rather than control flow. We present scenarios for behavior adaptation and identify the need for new scoping mechanisms. The increasing number of scoping mechanisms calls for new language abstractions representing them. We suggest to open the implementation of scoping mechanisms so that developers can extend the COP language core according to their specific needs. Our open implementation moves layer composition into objects to be affected and with that closer to the method dispatch to be changed. We discuss the implementation of established COP scoping mechanisms using our approach and present new scoping mechanisms developed for our enhancements to Lively Kernel. 相似文献
5.
Huth J Buchholz M Kraus JM Mølhave K Gradinaru C v Wichert G Gress TM Neumann H Kestler HA 《Computer methods and programs in biomedicine》2011,104(2):227-234
The direct observation of cells over time using time-lapse microscopy can provide deep insights into many important biological processes. Reliable analyses of motility, proliferation, invasive potential or mortality of cells are essential to many studies involving live cell imaging and can aid in biomarker discovery and diagnostic decisions. Given the vast amount of image- and time-series data produced by modern microscopes, automated analysis is a key feature to capitalize the potential of time-lapse imaging devices. To provide fast and reproducible analyses of multiple aspects of cell behaviour, we developed TimeLapseAnalyzer. Apart from general purpose image enhancements and segmentation procedures, this extensible, self-contained, modular cross-platform package provides dedicated modalities for fast and reliable analysis of multi-target cell tracking, scratch wound healing analysis, cell counting and tube formation analysis in high throughput screening of live-cell experiments. TimeLapseAnalyzer is freely available (MATLAB, Open Source) at http://www.informatik.uni-ulm.de/ni/mitarbeiter/HKestler/tla. 相似文献
6.
Malte Diehl 《Datenschutz und Datensicherheit - DuD》2008,32(4):243-247
Zusammenfassung Im Oktober 2007 trat in Gro?britannien ein Gesetz in Kraft, das es den Polizeibeh?rden erlaubt, die Herausgabe kryptographischer
Schlüssel von ihren Nutzern zu verlangen. Dies ist nur eine von zahlreichen Ma?nahmen, die einen globalen Kurswechsel hin
zu verst?rkter überwachung und Regulierung von Verschlüsselungsmechanismen belegen. In diesem Beitrag werden die Entwicklungen
der Kryptographiegesetzgebung der letzten Jahre und ihr heutiger Stand dokumentiert.
Dipl.-Inform. Malte Diehl Doktorand an der Uni Oldenburg, Department für Informatik, Stipendiat der DFG 相似文献
7.
Malte H.G. Wichmann Jan Sumfleth Marino Quaresimin Karl Schulte 《Engineering Fracture Mechanics》2006,73(16):2346-2359
Nanoparticles and especially carbon nanotubes (CNTs) provide a high potential for the modification of polymers. They are very effective fillers regarding mechanical properties, especially toughness. Furthermore, they allow the implication of functional properties, which are connected to their electrical conductivity, into polymeric matrices. In the present paper, different nanoparticles, as fumed silica and carbon black, were used to optimise the epoxy matrix system of a glass-fibre-reinforced composite. Their nanometre-size enables their application as particle-reinforcement in FRPs produced by the resin-transfer-moulding method (RTM), without being filtered by the glass-fibre bundles. Additionally, an electrical field was applied during curing, in order to enhance orientation of the nanofillers in z-direction. The interlaminar shear strengths of the nanoparticle modified composites were significantly improved (+16%) by adding only 0.3 wt.% of CNTs. The interlaminar toughness GIc and GIIc was not affected in a comparable manner. The laminates containing carbon nanotubes exhibited a relatively high electrical conductivity at very low filler contents, which allows the implication of functional properties, such as stress-strain monitoring and damage detection. 相似文献
8.
Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series
Christian Baumeier Ganna Aleshcheva Dominik Harms Ulrich Gross Christian Hamm Birgit Assmus Ralf Westenfeld Malte Kelm Spyros Rammos Philip Wenzel Thomas Münzel Albrecht Elssser Mudather Gailani Christian Perings Alae Bourakkadi Markus Flesch Tibor Kempf Johann Bauersachs Felicitas Escher Heinz-Peter Schultheiss 《International journal of molecular sciences》2022,23(13)
Myocarditis in response to COVID-19 vaccination has been reported since early 2021. In particular, young male individuals have been identified to exhibit an increased risk of myocardial inflammation following the administration of mRNA-based vaccines. Even though the first epidemiological analyses and numerous case reports investigated potential relationships, endomyocardial biopsy (EMB)-proven cases are limited. Here, we present a comprehensive histopathological analysis of EMBs from 15 patients with reduced ejection fraction (LVEF = 30 (14–39)%) and the clinical suspicion of myocarditis following vaccination with Comirnaty® (Pfizer-BioNTech) (n = 11), Vaxzevria® (AstraZenica) (n = 2) and Janssen® (Johnson & Johnson) (n = 2). Immunohistochemical EMB analyses reveal myocardial inflammation in 14 of 15 patients, with the histopathological diagnosis of active myocarditis according the Dallas criteria (n = 2), severe giant cell myocarditis (n = 2) and inflammatory cardiomyopathy (n = 10). Importantly, infectious causes have been excluded in all patients. The SARS-CoV-2 spike protein has been detected sparsely on cardiomyocytes of nine patients, and differential analysis of inflammatory markers such as CD4+ and CD8+ T cells suggests that the inflammatory response triggered by the vaccine may be of autoimmunological origin. Although a definitive causal relationship between COVID-19 vaccination and the occurrence of myocardial inflammation cannot be demonstrated in this study, data suggest a temporal connection. The expression of SARS-CoV-2 spike protein within the heart and the dominance of CD4+ lymphocytic infiltrates indicate an autoimmunological response to the vaccination. 相似文献
9.
M. Czernohorsky T. MeldeV. Beyer M.F. BeugJ. Paul R. HoffmannR. Knöfler A.T. Tilke 《Microelectronic Engineering》2011,88(7):1178-1181
In this work it is shown that film stress in the gate stack of TANOS NAND memories plays an important role for cell device performance and reliability. Tensile stress induced by a TiN metal gate deteriorates TANOS cell retention compared to TaN gate material. However, the erase saturation level as well as cell endurance is improved by the use of a TiN gate. This trade-off between retention and erase saturation for TANOS cells is elaborated in detail. 相似文献
10.
Forschung im Ingenieurwesen - Die mechanischen Verluste von Verbrennungsmotoren hängen maßgeblich von den auftretenden Reibkräften innerhalb der Kolbengruppe ab. Da die Kolbengruppe... 相似文献