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1.
OBJECTIVES: Reoperative coronary artery bypass grafting presents unique challenges for myocardial preservation. The purpose of this study was to compare oxygenated blood cardioplegia with oxygenated crystalloid cardioplegia during reoperative coronary artery bypass grafting using transesophageal echocardiography to assess regional wall motion of the left ventricle before and after cardiopulmonary bypass. METHODS: Sixty-one patients undergoing reoperative coronary artery bypass grafting were prospectively randomized to receive oxygenated blood cardioplegia or oxygenated crystalloid cardioplegia delivered with a combined antegrade-retrograde technique. Transgastric short axis views of the left ventricle were made with transesophageal echocardiography during the operation before cardiopulmonary bypass and immediately after cardiopulmonary bypass. Regional wall motion was graded by a blinded observer, and before cardiopulmonary bypass scores were compared with after cardiopulmonary bypass scores. RESULTS: No significant differences were found in the change in regional wall motion score from before cardiopulmonary bypass to after cardiopulmonary bypass between the blood and crystalloid cardioplegia groups. CONCLUSIONS: This study found blood and crystalloid cardioplegia to be equally efficacious for myocardial preservation during reoperative coronary artery bypass grafting. 相似文献
2.
Kosinski JA 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》1992,39(1):159-161
Aging and acceleration sensitivity of certain fabrication lots of quartz resonators show a trend that may arise from a common predominating mechanism, such as stresses arising from the mounting structure. The presence or absence of such a trend is discussed. As part of the work on bulk-acoustic-wave (BAW) resonators, a database of all known parameters of the resonators in question was assembled. Resonator processing and electrical parameters were examined for correlations with the acceleration sensitivity. A similar effort was being undertaken in regard to resonator aging, and possible correlations between the aging and acceleration sensitivities of the various resonators were examined. The results for two such fabrication lots are shown. The magnitude of the observed aging was typically in the 10(-10) per day range. The identity of the common contributor is unknown at the present time. It is likely that mounting related stresses are the common contributor. 相似文献
3.
Kosinski JA Gualtieri JG Ballato A 《IEEE transactions on ultrasonics, ferroelectrics, and frequency control》1992,39(4):502-507
Experimental measurements of alpha quartz thermal expansion as reported in the literature have been critically analyzed. A recommended set of best measured values over the temperature range -50 degrees C to +150 degrees C have been determined, as have values for the coefficient of thermal linear expansion (CTE) and the thermoelastic coefficients. The impact of using the coefficients on determinations of quartz material temperature coefficients and on the calculation of temperature coefficients of frequency for the case of the AT-cut is discussed. 相似文献
4.
Martyna Zagrska-Dziok Patrycja Kleczkowska Ewa Oldzka Ramona Figat Marcin Sobczak 《International journal of molecular sciences》2021,22(7)
Polymeric hydrogels play an increasingly important role in medicine, pharmacy and cosmetology. They appear to be one of the most promising groups of biomaterials due to their favorable physicochemical properties and biocompatibility. The objective of the presented study was to synthesize new poly(chitosan-ester-ether-urethane) hydrogels and to study the kinetic release of genistein (GEN) from these biomaterials. In view of the above, six non-toxic hydrogels were synthesized via the Ring-Opening Polymerization (ROP) and polyaddition processes. The poly(ester-ether) components of the hydrogels have been produced in the presence of the enzyme as a biocatalyst. In some cases, the in vitro release rate of GEN from the obtained hydrogels was characterized by near-zero-order kinetics, without “burst release” and with non-Fickian transport. It is important to note that developed hydrogels have been shown to possess the desired safety profile due to lack of cytotoxicity to skin cells (keratinocytes and fibroblasts). Taking into account the non-toxicity of hydrogels and the relatively highly controlled release profile of GEN, these results may provide fresh insight into polymeric hydrogels as an effective dermatological and/or cosmetological tool. 相似文献
5.
Joanna Czajkowska Adam Junka Jakub Hoppe Monika Toporkiewicz Andrzej Pawlak Pawe Migda Monika Oleksy-Wawrzyniak Karol Fijakowski Marcin
miglak Agata Markowska-Szczupak 《International journal of molecular sciences》2021,22(11)
Staphylococcus aureus is one of the most prevalent pathogens associated with several types of biofilm-based infections, including infections of chronic wounds. Mature staphylococcal biofilm is extremely hard to eradicate from a wound and displays a high tendency to induce recurring infections. Therefore, in the present study, we aimed to investigate in vitro the interaction between S. aureus biofilm and fibroblast cells searching for metabolites that could be considered as potential biomarkers of critical colonization and infection. Utilizing advanced microscopy and microbiological methods to examine biofilm formation and the staphylococcal infection process, we were able to distinguish 4 phases of biofilm development. The analysis of staphylococcal biofilm influence on the viability of fibroblasts allowed us to pinpoint the moment of critical colonization—12 h post contamination. Based on the obtained model we performed a metabolomics analysis by 1H NMR spectroscopy to provide new insights into the pathophysiology of infection. We identified a set of metabolites related to the switch to anaerobic metabolism that was characteristic for staphylococcal biofilm co-cultured with fibroblast cells. The data presented in this study may be thus considered a noteworthy but preliminary step in the direction of developing a new, NMR-based tool for rapid diagnosing of infection in a chronic wound. 相似文献
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8.
The problem of computing the chromatic number of a P
5-free graph (a graph which contains no path on 5 vertices as an induced subgraph) is known to be NP-hard. However, we show
that for every fixed integer k, there exists a polynomial-time algorithm determining whether or not a P
5-free graph admits a k-coloring, and finding one, if it does. 相似文献
9.
Marcin Miłkowski 《Minds and Machines》2009,19(4):465-475
In Darwin’s Dangerous Idea, Daniel Dennett claims that evolution is algorithmic. On Dennett’s analysis, evolutionary processes are trivially algorithmic
because he assumes that all natural processes are algorithmic. I will argue that there are more robust ways to understand
algorithmic processes that make the claim that evolution is algorithmic empirical and not conceptual. While laws of nature
can be seen as compression algorithms of information about the world, it does not follow logically that they are implemented
as algorithms by physical processes. For that to be true, the processes have to be part of computational systems. The basic
difference between mere simulation and real computing is having proper causal structure. I will show what kind of requirements
this poses for natural evolutionary processes if they are to be computational. 相似文献
10.
Application of the OBD method for optimization of neural state variable estimators of the two-mass drive system 总被引:1,自引:0,他引:1
This paper presents neural estimators of the mechanical state variables of the electrical drive system with elastic joints. The non-measurable state variables, as the torsional torque and the load machine speed are estimated using multilayer feed-forward neural networks. The main stages of the design methodology of these neural estimators are presented. The optimal brain damage method is implemented for the structure optimization of each neural network. Then signals estimated by neural estimators are tested in the electrical drive control structure with additional feedbacks from the estimated shaft torque and the difference between the motor and the load speeds. The simulation results show good accuracy of both presented neural estimators for the wide range of changes of the reference speed and the load torque. The simulation results are then verified by laboratory experiments. 相似文献