PNET “ONDM 2019” special issue

Photonic Network Communications -     

Assessment of tremor activity in the Parkinson's disease using a set of wearable sensors

Tremor is the most common motor disorder of Parkinson's disease (PD) and consequently its detection plays a crucial role in the management and treatment of PD patients. The current diagnosis procedure is based on subject-dependent clinical assessment, which has a difficulty in capturing subtle tremor features. In this paper, an automated method for both resting and action/postural tremor assessment is proposed using a set of accelerometers mounted on different patient's body segments. The estimation of tremor type (resting/action postural) and severity is based on features extracted from the acquired signals and hidden Markov models. The method is evaluated using data collected from 23 subjects (18 PD patients and 5 control subjects). The obtained results verified that the proposed method successfully: 1) quantifies tremor severity with 87 % accuracy, 2) discriminates resting from postural tremor, and 3) discriminates tremor from other Parkinsonian motor symptoms during daily activities.     

A general class of nonparametric control charts

In this article, we introduce a new general class of nonparametric Shewhart‐type control charts using the lengths of runs of test sample observations between successive observations of a reference sample. Several control charts that have appeared in the literature are members of the new family. In addition, 3 new nonparametric control charts that belong to the class are introduced and studied. Numerical results depict that the proposed charts attain competitive in‐control and out‐of‐control performance as compared with existing nonparametric charts.     

Layer‐By‐Layer Electropeeling of Organic Conducting Material Imaged In Real Time

Soft materials comprising low‐molecular‐weight organic molecules are attracting increasing interest because of their importance in the development of a number of emerging areas in nanoscience and technology, including molecular electronics, nanosystems for energy conversion, and devices in the widest sense. Their interaction with electrodes and their behavior under electric fields is a topic of vital significance for these areas, and about which very little is known. Here unprecedented evidence is presented for the controlled peeling of organic molecular material when a voltage is applied between the conducting system and the conducting probe of a scanning force microscope. The rate of removal of the material from the surface of the bulk conducting supramolecular material can be tuned. It depends on the potential applied and is initiated only above a threshold value of 200 mV. The results indicate the importance of electric fields on the stability and performance of conducting organic systems at the nanoscale.     

Renewable energy sources (RES) projects and their barriers on a regional scale: The case study of wind parks in the Dodecanese islands, Greece

The increasing energy challenges faced, in particular, by isolated communities, such as insular communities, call for an integrated, flexible and easy-to-apply methodology aiming at providing a list of renewable energy sources) (RES) projects capable to reduce green house gas (GHG) emissions, satisfy future energy forecasts and reach the objectives of international/national energy directives and obligations, as, for example, the ones set by the Kyoto Protocol by 2010. The EU project EMERGENCE 2010 developed such a methodology that is implemented here in the case study of wind parks in the Dodecanese islands in Greece. The results obtained consist of a final list of financially viable RES wind projects, for which various barriers have been previously identified and assessed. The additional advantages of the proposed methodology is that besides providing as an end result a comprehensive list of RES projects adopted to specific criteria and regional priorities, it also allows space for involving – from early stages – the local community and stakeholders in the decision-making process (participatory planning); in this way, the EMERGENCE 2010 methodology may assist towards the RES promotion and public acceptance, the profitability of RES investments and the regional sustainable development.     

An optimized sequential pattern matching methodology for sequence classification

In this paper we present a novel methodology for sequence classification, based on sequential pattern mining and optimization algorithms. The proposed methodology automatically generates a sequence classification model, based on a two stage process. In the first stage, a sequential pattern mining algorithm is applied to a set of sequences and the sequential patterns are extracted. Then, the score of every pattern with respect to each sequence is calculated using a scoring function and the score of each class under consideration is estimated by summing the specific pattern scores. Each score is updated, multiplied by a weight and the output of the first stage is the classification confusion matrix of the sequences. In the second stage an optimization technique, aims to finding a set of weights which minimize an objective function, defined using the classification confusion matrix. The set of the extracted sequential patterns and the optimal weights of the classes comprise the sequence classification model. Extensive evaluation of the methodology was carried out in the protein classification domain, by varying the number of training and test sequences, the number of patterns and the number of classes. The methodology is compared with other similar sequence classification approaches. The proposed methodology exhibits several advantages, such as automated weight assignment to classes using optimization techniques and knowledge discovery in the domain of application.

Systems development approach: transcending methodology

Abstract.  This paper presents the findings of an empirical study investigating the nature of the process of information systems development. These findings are used to identify systems development approach, which extends understanding of the information systems development process beyond the levels of methodology and technical expertise. The term approach expresses the rich, varied, and complex ways in which professionals deal with development situations. The term transcends methodological components – which can be combined, tailored, or omitted altogether. Within approach, a framework for method choice, a key diagnostic scheme, and the use of a central repository reveal the significant background activity that goes into developing information systems. It is suggested that the information systems development process ultimately involves a professional using an approach to intervene in a problematic situation for developing the organization's information and, if needed, other systems. This understanding has implications for examining the field's ineffectiveness in relation to the approach adopted – rather than the methodology used.     

Continuous-time and discrete-time design of water flow and water level regulators

A thorough analysis of the water flow and water level control problems arising in several industrial systems is provided using classical and sampled data linear control theory. The analysis is based on simplified linear models of the processes under control. Resulting design rules enable engineers to choose the correct controller both in the continuous-time and in the discrete-time case. A practical application example is included.     

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

Biologically functional Ras isoforms undergo post-translational modifications starting with farnesylation of the most C-terminal cysteine. Combined with further processing steps, this isoprenylation allows for the anchoring of these proteins in endomembranes, where signal transduction events take place. The specific localization is subject to dynamic regulation and assumed to modulate the activity of Ras proteins by governing their spatiotemporal distribution. The delta subunit of phosphodiesterase (PDEdelta) has attracted attention as a solubilization factor of isoprenylated Ras. In this study, we demonstrate that critical residues in the putative isoprenoid pocket of PDEdelta can be mapped by coupling with a semisynthetic N-Ras lipoprotein in which the native farnesyl group of the processed protein was replaced by a photoactivatable geranyl benzophenone moiety. The crosslinked product included parts of beta-sheet 9 of PDEdelta, which contains the highly conserved amino acids V145 and L147. Modeling of the PDEdelta-geranyl benzophenone (GerBP) complex supports the conclusion that the photolabeled sequence is embedded in the putative isoprenoid pocket of PDEdelta.