Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Removing contaminants from transferred CVD graphene

Nano Research - Chemical vapor deposition (CVD) is among the most utilized techniques to fabricate single-layer graphene on a large substrate. However, the substrate is limited to very few...     

三级连续碳化法生产纳米碳酸钙新工艺研究

采用有效容积依次递增的预塔、中塔、后塔三个碳化塔串联,塔内气液连续逆流操作、塔间气液连续并流或错流操作,严格控制氢氧化钙浆液的浓度、流量、温度和碳化气的浓度、流量,并通过pH计或电导仪进行跟踪检测碳化度,可实现纳米碳酸钙生产工艺连续化、产品质量稳定化、产量规模化.     

我国典型地区产业结构演进探析——以徐州为例

徐州作为全国较大的市,人均GDP接近全国水平,产业结构在国内也颇具典型性。改革开放以来,徐州的产业结构演进符合全国发展的一般规律。本文通过实证与规范分析,结合相关理论,逐一验证了经济的发展阶段,并以徐州为范例,提出了结构创新及主导产业战略选择的一般原则。     

The application of plasma-sprayed ceramic coatings on lift roller in float glass

Oxide ceramic was sprayed via high-energy plasma spray using MCrAlY manufactured with special technique as bond coating and oxide ceramic as top coating in this article. Investigation showed that the dense and highly adhesive coating could be obtained with optimized technique. After grinding and polishing, coating roughness was lower than 0. 2μm, which could meet the requirements of lift roller. After one year serv ice, molten Tin could not adhere to the ceramic coating,well it greatly alleviated its corrosion to the roller , kept the surface of oxide ceramic coating smooth and the improve the quality of glass due to the strengthened lift roll.     

浅析某大桥混凝土异形块防裂缝施工措施

从基础施工、支架搭设、材料检验、混凝土浇注等方面详细介绍了某大桥混凝土异形块施工过程,并浅析了防止大体积、大面积现浇混凝土板裂缝的措施和方法。     

赤泥脱硫剂的配制与应用

介绍了采用赤泥制备脱硫剂以及用其进行城市煤气脱硫的方法，以赤泥制备的脱硫剂对城市煤气中H2S的脱除率可达98％以上，同时探讨了脱硫剂的再生方法。     

基于体积配比原理的乳化液自动配比装置

根据乳化液的人工配置存在的配比浓度不稳定,常常达不到《煤矿安全规程》规定的3%~5%的要求,介绍了一种基于体积配比原理的乳化液自动配比装置,该装置配置的乳化液浓度不仅达到了《煤矿安全规程》规定的浓度,而且配比浓度稳定且配置的乳化液高度清洁,完全达到了煤矿技术要求。     

用五力模型分析煤炭运销专营的必然性

从新进入者和替代者的威胁、买方和供方议价能力，以及行业竞争对手之间的竞争威胁等方面，用反证法得出了我国实行煤炭运销专营的必然性。通过山西煤炭运销专营的实证研究，提出了5点政策建议：制订《中国煤炭专营法》；设立市场准入门槛、建立区域间煤种间的合理比价关系、完善国家煤炭市场交易体系和建立约束机制。     

蒸气相中煤矸石自转变合成沸石基吸附剂

研究了 3 73～ 40 0K温度范围内 ,煤矸石在乙胺和水的蒸汽相中自转变合成纯度、结晶度均较高的沸石基吸附剂的过程 ,并对其吸附性能做了初步研究。通过沸石基吸附剂对苯酚的吸附实验 ,给出它对苯酚的吸附等温线。该吸附剂为灰白色 ,对含酚废水中的酚类有较好的脱除性能 ,同时指出合理的吸附温度、大的比表面有助于提高其吸附量。