Peripheral mRNA Expression and Prognostic Significance of Emotional Stress Biomarkers in Metastatic Breast Cancer Patients

Emotional stress is believed to be associated with increased tumor progression. Stress-induced epigenetic modifications can contribute to the severity of disease and poor prognosis in cancer patients. The current study aimed to investigate the expression profiles along with the prognostic significance of psychological stress-related genes in metastatic breast cancer patients, to rationalize the molecular link between emotional stress and cancer progression. We profiled the expression of selected stress-associated genes (5-HTT, NR3C1, OXTR, and FKBP5) in breast cancer including the stress evaluation of all participants using the Questionnaire on Distress in Cancer Patients–short form (QSC-R10). A survival database, the Kaplan–Meier Plotter, was used to explore the prognostic significance of these genes in breast cancer. Our results showed relatively low expressions of 5-HTT (p = 0.02) and OXTR (p = 0.0387) in metastatic breast cancer patients as compared to the non-metastatic group of patients. The expression of NR3C1 was low in tumor grade III as compared to grade II (p = 0.04). Additionally, the expression of NR3C1 was significantly higher in patients with positive estrogen receptor status. However, no significant difference was found regarding FKBP5 expression in breast cancer. The results suggest a potential implication of these genes in breast cancer pathology and prognosis.     

Electrolyte/Structure?Dependent Cocktail Mediation Enabling High?Rate/Low?Plateau Metal Sulfide Anodes for Sodium Storage

As promising anodes for sodium-ion batteries, metal sulfides ubiquitously suffer from low-rate and high-plateau issues, greatly hindering their application in f...     

Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia

Antipsychotics (AP) induced prolongation of the QT interval in patients with schizophrenia (Sch) is an actual interdisciplinary problem as it increases the risk of sudden death syndrome. Long QT syndrome (LQTS) as a cardiac adverse drug reaction is a multifactorial symptomatic disorder, the development of which is influenced by modifying factors (APs’ dose, duration of APs therapy, APs polytherapy, and monotherapy, etc.) and non-modifying factors (genetic predisposition, gender, age, etc.). The genetic predisposition to AP-induced LQTS may be due to several causes, including causal mutations in the genes responsible for monoheme forms of LQTS, single nucleotide variants (SNVs) of the candidate genes encoding voltage-dependent ion channels expressed both in the brain and in the heart, and SNVs of candidate genes encoding key enzymes of APs metabolism. This narrative review summarizes the results of genetic studies on AP-induced LQTS and proposes a new personalized approach to assessing the risk of its development (low, moderate, high). We recommend implementation in protocols of primary diagnosis of AP-induced LQTS and medication dispensary additional observations of the risk category of patients receiving APs, deoxyribonucleic acid profiling, regular electrocardiogram monitoring, and regular therapeutic drug monitoring of the blood APs levels.     

Radioactivity concentrations in soil and dose assessment for Samsun City Centre, Turkey

In this study, natural gamma radioactivity levels were determined in the soil samples of the Samsun city centre by using the gamma ray spectrometry method. The analysis carried out with the high-purity germanium gamma spectrometry system has shown that average activity concentrations of (238)U, (232)Th, (40)K and (137)Cs were 19±2, 22±4, 521±23 and 15±1 Bq kg(-1), respectively. From the gamma analysis of soil samples, the average value of the absorbed gamma dose rates in air and the average value of the external annual effective dose rates were calculated as 45±4 nGy h(-1) and 55±5 μSv y(-1), respectively. The external hazard index has also been calculated and it has been found that the radiation hazard in Samsun is insignificant.     

Biosorption of cadmium(II) from aqueous solution by red algae (Ceramium virgatum): equilibrium, kinetic and thermodynamic studies

The biosorption characteristics of Cd(II) ions using the red alga (Ceramium virgatum) were investigated. Experimental parameters affecting the biosorption process such as pH, contact time, biomass dosage and temperature were studied. Langmuir, Freundlich and Dubinin-Radushkevich (D-R) models were applied to describe the biosorption isotherms. The biosorption capacity of C. virgatum biomass for Cd(II) ions was found to be 39.7 mg/g. From the D-R isotherm model, the mean free energy was calculated as 12.7 kJ/mol, indicating that the biosorption of Cd(II) the metal ions was taken place by chemisorption. The calculated thermodynamic parameters (DeltaG degrees , DeltaH degrees and DeltaS degrees ) showed that the biosorption of Cd(II) ions onto C. virgatum was feasible, spontaneous and exothermic at 293-323 K. Evaluation of experimental data in terms of biosorption kinetics showed that the biosorption of Cd(II) C. virgatum followed well pseudo-second-order kinetics.     

Predicting construction crew productivity by using Self Organizing Maps

A Self Organizing Map (SOM), is a machine learning method that represents high-dimensional data in low-dimensional form without losing topological relations of the data. After an unsupervised learning process, it organizes the data on the basis on similarity. In the current study, a SOM based algorithm has been developed which not only produces 2-D maps to analyze the relationship between various factors and crew productivity, but also predicts productivity under given conditions. Validation of the model has been achieved both by using artificial data set and data from 144 concrete pouring, 101 formwork and 101 reinforcement crews. The results show that maps which are produced by the model are satisfactory in clustering the data and prediction performance of the model is superior to similar artificial neural network models.     

The economical and international dimensions of the environmental problems,environmental problems in the Black Sea region and the role of the voluntary organizations

Differently than in the past, today environmental problems have local, national and international concern. The environmental problems in the Black Sea region are a good example for this phenomenon. These problems have affected all six countries that have shores with the Black Sea. The current study analyses these problems in detail. It intends to detect potential reasons for problems and provide suggestions to solve these problems by considering the economic dimensions. In addition, the impact of problems on the city life is examined. Also, the roles and importance of voluntary organizations on solving environmental problems are emphasized.