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Within the framework of the energy-based strength criterion, the transition from the stress space to the stress-intensity-factor space is performed in a such way so that the fracture criterion obtained contains all characteristics of the material crack resistance
, as well as dimensions
and
of the local fracture zone at the crack-tip vicinity under different modes of the crack-face loading. We propose an alternative approximation of the fracture criterion, which is exact in terms of the model under consideration. The theoretical results are compared with some known experiments. An example of the calculation of a structural element with a macrocrack is given. 相似文献
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Chronic Immune Platelet Activation Is Followed by Platelet Refractoriness and Impaired Contractility
Izabella A. Andrianova Alina I. Khabirova Anastasia A. Ponomareva Alina D. Peshkova Natalia G. Evtugina Giang Le Minh Timur B. Sibgatullin John W. Weisel Rustem I. Litvinov 《International journal of molecular sciences》2022,23(13)
Autoimmune diseases, including systemic lupus erythematosus (SLE), have a high risk of thrombotic and hemorrhagic complications associated with altered platelet functionality. We studied platelets from the blood of SLE patients and their reactivity. The surface expression of phosphatidylserine, P-selectin, and active integrin αIIbβ3 were measured using flow cytometry before and after platelet stimulation. Soluble P-selectin was measured in plasma. The kinetics of platelet-driven clot contraction was studied, as well as scanning and transmission electron microscopy of unstimulated platelets. Elevated levels of membrane-associated phosphatidylserine and platelet-attached and soluble P-selectin correlated directly with the titers of IgG, anti-dsDNA-antibodies, and circulating immune complexes. Morphologically, platelets in SLE lost their resting discoid shape, formed membrane protrusions and aggregates, and had a rough plasma membrane. The signs of platelet activation were associated paradoxically with reduced reactivity to a physiological stimulus and impaired contractility that revealed platelet exhaustion and refractoriness. Platelet activation has multiple pro-coagulant effects, and the inability to fully contract (retract) blood clots can be either a hemorrhagic or pro-thrombotic mechanism related to altered clot permeability, sensitivity of clots to fibrinolysis, obstructiveness, and embologenicity. Therefore, chronic immune platelet activation followed by secondary platelet dysfunction comprise an understudied pathogenic mechanism that supports hemostatic disorders in autoimmune diseases, such as SLE. 相似文献
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Alina D. Peshkova Tatiana A. Evdokimova Timur B. Sibgatullin Fazoil I. Ataullakhanov Rustem I. Litvinov John W. Weisel 《International journal of molecular sciences》2020,21(24)
Rheumatoid arthritis (RA) is an autoimmune disease associated with thrombotic complications. To elucidate pathogenic mechanisms, hemostatic disorders in RA were correlated with other laboratory and clinical manifestations. Hemostasis was assessed using relatively new complementary tests, the spatial growth of a plasma clot (Thrombodynamics assay), and contraction of whole blood clots. Platelet functionality was assessed with flow cytometry that quantified the expression of P-selectin and the fibrinogen-binding capacity of platelets before and after activation with a thrombin receptor-activating peptide. Parameters of fibrin clot growth and the kinetics of contraction of blood clots were significantly altered in patients with RA compared to the control group. In Thrombodynamics measurements, an increase in the clot growth rate, size, and optical density of plasma clots altogether indicated chronic hypercoagulability. The rate and extent of blood clot contraction in patients with RA was significantly reduced and associated with platelet dysfunction revealed by an impaired response to activation. Changes in the parameters of clot growth and contraction correlated with the laboratory signs of systemic inflammation, including hyperfibrinogenemia. These results confirm the pathogenic role of hemostatic disorders in RA and support the validity of fibrin clot growth and the blood clot contraction assay as indicators of a (pro)thrombotic state. 相似文献
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