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排序方式: 共有231条查询结果,搜索用时 15 毫秒
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Michael Singh Serhat Akkaya Mark Preuß Franziska Rademacher Mersedeh Tohidnezhad Yusuke Kubo Peter Behrendt Jan-Tobias Weitkamp Thilo Wedel Ralph Lucius Regine Glser Jürgen Harder Andreas Bayer 《International journal of molecular sciences》2022,23(5)
Platelet-released growth factors (PRGFs) or other thrombocyte concentrate products, e.g., Platelet-Rich Fibrin (PRF), have become efficient tools of regenerative medicine in many medical disciplines. In the context of wound healing, it has been demonstrated that treatment of chronic or complicated wounds with PRGF or PRF improves wound healing in the majority of treated patients. Nevertheless, the underlying cellular and molecular mechanism are still poorly understood. Therefore, we aimed to analyze if PRGF-treatment of human keratinocytes caused the induction of genes encoding paracrine factors associated with successful wound healing. The investigated genes were Semaphorin 7A (SEMA7A), Angiopoietin-like 4 (ANGPLT4), Fibroblast Growth Factor-2 (FGF-2), Interleukin-32 (IL-32), the CC-chemokine-ligand 20 (CCL20), the matrix-metalloproteinase-2 (MMP-2), the chemokine C-X-C motif chemokine ligand 10 (CXCL10) and the subunit B of the Platelet-Derived Growth Factor (PDGFB). We observed a significant gene induction of SEMA7A, ANGPLT4, FGF-2, IL-32, MMP-2 and PDGFB in human keratinocytes after PRGF treatment. The CCL20- and CXCL10 gene expressions were significantly inhibited by PRGF therapy. Signal transduction analyses revealed that the PRGF-mediated gene induction of SEMA7A, ANGPLT4, IL-32 and MMP-2 in human keratinocytes was transduced via the IL-6 receptor pathway. In contrast, EGF receptor signaling was not involved in the PRGF-mediated gene expression of analyzed genes in human keratinocytes. Additionally, treatment of ex vivo skin explants with PRGF confirmed a significant gene induction of SEMA7A, ANGPLT4, MMP-2 and PDGFB. Taken together, these results describe a new mechanism that could be responsible for the beneficial wound healing properties of PRGF or related thrombocytes concentrate products such as PRF. 相似文献
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Foundations of Fast Communication via XML 总被引:3,自引:0,他引:3
Communication with XML often involves pre-agreed document types. In this paper, we propose an offline parser generation approach to enhance online processing performance for documents conforming to a given DTD. Our examination of DTDs and the languages they define demonstrates the existence of ambiguities. We present an algorithm that maps DTDs to deterministic context-free grammars defining the same languages. We prove the grammars to be LL(1) and LALR(1), making them suitable for standard parser generators. Our experiments show the superior performance of generated optimized parsers. Our results generalize from DTDs to XML schema specifications with certain restrictions, most notably the absence of namespaces, which exceed the scope of context-free grammars. 相似文献
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An Integrative Model of Mobile Phone Appropriation 总被引:1,自引:0,他引:1
Werner Wirth Thilo von Pape Veronika Karnowski 《Journal of Computer-Mediated Communication》2008,13(3):593-617
The evolution of mobile communication devices and services has taken up a dynamic that makes any prognosis in the field almost impossible. Whereas part of this dynamic may remain inscrutable, we believe that a much higher degree of explanation can be achieved by systematically paying closer attention to the process of appropriation. To seize upon this potential, we present an integrative model to analyze mobile phone appropriation (the "MPA model").
The model is based on existing theoretical approaches of the quantitative "adoption" paradigm (namely, Innovation Diffusion Theory and Theory of Planned Behavior) as well as the mostly qualitative research paradigm devoted to "appropriation" (Cultural studies and Frame Analysis), with the Uses-and-Gratifications approach playing a role on both sides. The model has been developed, operationalized and empirically applied in the context of mobile phone appropriation; however, with certain modifications it can be adapted to other information and communications technology (ICT) innovations. 相似文献
The model is based on existing theoretical approaches of the quantitative "adoption" paradigm (namely, Innovation Diffusion Theory and Theory of Planned Behavior) as well as the mostly qualitative research paradigm devoted to "appropriation" (Cultural studies and Frame Analysis), with the Uses-and-Gratifications approach playing a role on both sides. The model has been developed, operationalized and empirically applied in the context of mobile phone appropriation; however, with certain modifications it can be adapted to other information and communications technology (ICT) innovations. 相似文献