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1.
RJ Linnola RP Happonen OH Andersson E Vedel AU Yli-Urpo U Krause L Laatikainen 《Canadian Metallurgical Quarterly》1996,63(4):471-478
The current problem with keratoprosthesis is the ingrowth of corneal or conjunctival epithelium into the anterior chamber. This may lead to infections and extrusion of the prosthesis as well as to the development of retroprosthetic membrane and secondary glaucoma. Glass-ceramic coated and uncoated titanium has been tested as material for the keratoprosthesis to prevent epithelial ingrowth. Twenty-two Supra-Descemet's membrane keratoprostheses were inserted in the eyes of 22 rabbits for 1, 2, 4, 8, or 12 months. The prosthesis had an optic part made of polymethylmetacrylate (PMMA). The support for the optic part and the flange of the prosthesis were made of titanium. Eleven of the prostheses were coated with glass-ceramic. The histological sections of the enucleated eyes were prepared through the central part of the cornea and the prosthesis using a cutting-grinding method. The histological analysis was made on both halves of the implants separately giving two analysis areas in each eye. All 11 titanium prostheses were retained for the time period planned. Two glass-ceramic coated prostheses were lost at 2 and 4 weeks, respectively. This was caused by difficulties at surgery due to a thick coating. These eyes were excluded from the histological analysis. No significant ingrowth of epithelium was seen in 15/18 (83%) and in 16/22 (73%) of the analysed areas of the glass-ceramic coated and titanium prostheses, respectively. Titanium appears to be a suitable material for the keratoprosthesis. The ingrowth of the epithelium may be hindered further by coating the titanium with bioactive glass-ceramic. 相似文献
2.
AU Teuscher M Lerch S Shaw G Pacini P Ferrari P Weidmann 《Canadian Metallurgical Quarterly》1998,16(9):1279-1284
OBJECTIVES: Elevated plasma endothelin (ET)-1 levels have been described in insulin-resistant states such as syndrome X, obesity, non-insulin-dependent diabetes mellitus, and in some studies in essential hypertension. To investigate whether increases in circulating ET-1 to levels observed in insulin-resistant states can modulate insulin levels and/or insulin sensitivity in humans, we assessed these variables during low, non-pressor-dose ET-1 compared with placebo infusion. DESIGN: In a randomized, single blind, crossover design, 10 lean normotensive male subjects received either an intravenous infusion of subpressor doses of ET-1 dissolved in polygeline or a control infusion of polygeline only (placebo). Using dynamic assessment by the minimal model approach with the modified frequent sampling intravenous glucose tolerance test (FSIGT) the following and other parameters were measured: insulin sensitivity; acute insulin response to glucose (AIR(G)) calculated as the average of the three peak values between 2 and 5 min after injection of glucose from which the basal insulin levels were subtracted; the initial area under the curve (AUC(1-19)) from insulin values between time 0 and 19 min and the first-phase insulin secretion (phi1) from insulin kinetics parameters. RESULTS: ET-1 infusion reduced AIR(G) (to 34.85 +/- 4.27 compared with 49.3 +/- 6.9 microU/ml during placebo, P=0.017) and the acute C-peptide response to glucose (to 2.33 +/- 0.41 compared with 3.1 +/- 0.44 ng/ml, P=0.018), decreased plasma insulin levels during the FSIGT compared with placebo (analysis of variance P<0.0001) and decreased the AUC(1-19) (to 2.1 +/- 0.2 compared with 2.9 +/- 0.3 U/l per 20 min, P<0.01) while phi1 tended to be lower. S1 measured during ET-1 infusion was unaltered (11.11 +/- 1.91 x 10(-4) versus 10.88 +/- 2.11 10(-4)/min per mU per l, NS). CONCLUSIONS: These findings demonstrate that an increase in circulating ET-1 to levels observed in insulin-resistant states acutely diminishes the insulin secretory response but does not significantly modify insulin sensitivity. 相似文献
3.
S Chang SL Parker T Pham AU Buzdar SD Hursting 《Canadian Metallurgical Quarterly》1998,82(12):2366-2372
BACKGROUND: Little is known about the cause of inflammatory breast carcinoma (IBC), the most aggressive form of breast cancer. To the authors' knowledge, no studies have investigated whether IBC risk factors are different from those for breast carcinoma overall, and there has been only one report of IBC incidence and survival patterns. METHODS: The authors used data from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute for the period 1975-1992 to calculate age-adjusted incidence and survival rates for 913 white and 121 African American women with IBC involving dermal invasion of lymphatic ducts and 166,375 white and 13,674 African American women with other types of breast carcinoma (non-IBC). RESULTS: Between 1975-1977 and 1990-1992, IBC incidence doubled, increasing among whites from 0.3 to 0.7 cases per 100,000 person-years and among African Americans from 0.6 to 1.1 cases. However, rates for African Americans varied due to the small numbers of IBC cases. The twofold increase in IBC incidence was higher than that observed for non-IBC during the same period (27% for African Americans and 25% for whites). IBC patients were significantly younger at diagnosis than non-IBC patients; and among both IBC and non-IBC patients, African Americans were younger than whites. Overall survival was significantly worse for IBC patients than for non-IBC patients and for African Americans than for whites. Among whites, 3-year survival improved more for IBC patients than for non-IBC patients between 1975-1979 and 1988-1992, increasing from 32% to 42% for IBC patients (P=0.0001) and from 80% to 85% for non-IBC patients (P=0.0001). CONCLUSIONS: The disparities observed in incidence trends and age at diagnosis, particularly according to race, highlight the need for further investigation of the differences between IBC and non-IBC incidence. 相似文献
4.
A. Alp Kindiroglu H. Yalcin O. Aran M. Hr��z P. Campr L. Akarun A. Karpov 《Pattern Recognition and Image Analysis》2012,22(4):527-536
This paper presents the design and evaluation of a multi-lingual fingerspelling recognition module that is designed for an information terminal. Through the use of multimodal input and output methods, the information terminal acts as a communication medium between deaf and blind people. The system converts fingerspelled words to speech and vice versa using fingerspelling recognition, fingerspelling synthesis, speech recognition and speech synthesis in Czech, Russian, and Turkish languages. We describe an adaptive skin color based fingersign recognition system with a close to real-time performance and present recognition results on 88 different letters signed by five different signers, using above four hours of training and test videos. 相似文献
5.
The clay nanoparticles are readily dispersed and exfoliated in the PVC matrix with the help of Dioctyl phthalate (DOP) plasticizer. X-ray, TEM and AFM analysis of the nanocomposites indicate that there is an optimum concentration of DOP for the process. If used in high concentrations, the ability to transfer forces to the clay particles through the polymer matrix decreases due to substantial decrease in viscosity. The individual platy montmorillonite particles dispersed in PVC matrix were directly observed by AFM and found to lie preferentially on their basal surfaces, especially when the compounded batch is compression molded. The edges of the particles were in some cases straight forming hexagonal angles and in other cases irregular. 相似文献
6.
Drug abusers, particularly those who inject drugs s.c. ("skin popping"), may develop amyloidosis. Chronic infections are thought to play a pathogenetic role in this setting. A patient is presented who had a history of "skin popping" cocaine and heroin and developed nephrotic syndrome, with an elevated serum creatinine and a creatinine clearance of 61 mL/min. Renal biopsy demonstrated amyloidosis. Treatment with colchicine was initiated, and proteinuria decreased to near normal levels after 12 months. Concomitant with the decrease in proteinuria, creatinine clearance improved, although a repeat renal biopsy failed to show any significant improvement in amyloid burden. These observations suggest that colchicine may be a useful treatment in reversing the proteinuria of renal amyloidosis associated with drug abuse. Furthermore, clinical improvement may occur before any demonstrable regression in the amyloidosis. 相似文献
7.
In this study, utilization of whey and grape must were investigated for citric acid production using Yarrowia lipolytica NBRC 1658 and a domestic strain Y. lipolytica 57. In addition to its use as a sole nutrient source, whey was also fortified with glucose or fructose as well as other nutrients. The best results for citric acid production were obtained in the medium containing whey supplemented with fructose. Maximum citric acid concentrations in this medium were 49.23 and 32.65 g/L for the domestic and NBRC 1658 strains, respectively. In grape must, maximum citric acid concentrations obtained using domestic and NBRC 1658 strains were 32.09 and 10.39 g/L, respectively. Both of the natural nutrient sources were found to be promising for utilization in citric acid production process. A domestic Turkish yeast strain was confirmed to be superior for citric acid production for the first time. This can be targeted for enhancing citric acid production efficiencies from locally available substrates such as whey or grape must. 相似文献
8.
9.
Hasan Yalcin Ismet ?zt��rk Eray Tuluk?u Osman Sa?dic 《Journal für Verbraucherschutz und Lebensmittelsicherheit》2011,6(2):197-202
Sar? 85 (Linum usitatissimum L.) linseed variety was used in this study. Linseed was cultivated at 2008 (LS-08) and 2009 (LS-09) without fertilizer. In addition, at 2009 diammonium phosphate [(NH4)2HPO4] and ammonium nitrate (NH4NO3) were applied (LSF-09). The linseeds were analyzed for protein, ash and oil contents and fatty acid compositions. There were differences among harvesting years for oil, protein and ash contents of the seeds. The greater oil and protein contents were obtained during LS-08 compared with LS-09. There were no significant difference in protein and ash content between LS-09 and LSF-09 while a significant difference was observed in oil content. Seed protein, oil and ash contents were significantly affected by the harvesting year, but only oil content was affected by the fertilizer treatment. There are significant differences in palmitic, stearic, oleic, ??-linolenic and arachidic acid between LS-08 and LS-09. While palmitic, stearic, oleic acid decreased, ??-linolenic and arachidic acid increased during 2009 harvesting year. LSF-09 has the highest amount of ??-linolenic acid. The fertilizing treatment seems to have an increasing effect on the amount of ??-linolenic acid, while it has a decreasing effect on the oleic acid content. 相似文献
10.