Clinical assessment research with older adults.

Methodological issues in geropsychological assessment research are discussed and exemplified with recent investigations. Increased use of short-term longitudinal designs, more diverse and representative sampling, and routine inclusion of measures of health are among the recommendations made for future studies. Caution is urged in the application of new tests or screening batteries until sufficient independent validation studies are completed. Research contrasting neuropsychological performance of older persons from different racial and ethnic groups is briefly reviewed, and applications of geropsychological assessment to practical arenas such as competency determination are critiqued. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease.

Objective: To examine the latent structure of a test battery currently being used in a longitudinal study of asymptomatic middle-aged adults with a parental history of Alzheimer's disease (AD) and test the invariance of the factor solution across subgroups defined by selected demographic variables and known genetic risk factors for AD. Method: An exploratory factor analysis (EFA) and a sequence of confirmatory factor analyses (CFA) were conducted on 24 neuropsychological measures selected to provide a comprehensive estimate of cognitive abilities most likely to be affected in preclinical AD. Once the underlying latent model was defined and the structural validity established through model comparisons, a multigroup confirmatory factor analysis model was used to test for factorial invariance across groups. Results: The EFA solution revealed a factor structure consisting of five constructs: verbal ability, visuospatial ability, speed & executive function, working memory, and verbal learning & memory. The CFA models provided support for the hypothesized 5-factor structure. Results indicated factorial invariance of the model across all groups examined. Conclusions: Collectively, the results suggested a relatively strong psychometric basis for using the factor structure in clinical samples that match the characteristics of this cohort. This confirmed an invariant factor structure should prove useful in research aimed to detect the earliest cognitive signature of preclinical AD in similar middle aged cohorts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychological assessment of older adults.

Older adults experience a diverse range of cognitive, emotional, and social problems for which psychological assessment may be beneficial. This article describes sequential steps in geropsychological assessment and reviews some of the procedures that can be used for making a differential diagnosis, establishing a baseline for longitudinal follow-up, or planning for interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Clinical tests of memory in dementia, depression, and healthy aging.

In Study 1, 20 elderly adults (mean age 72.7 yrs) with primary degenerative dementia or major depression were compared to 10 healthy aged controls on 3 tests of learning and memory: the Benton Visual Retention Test; a paired-associate learning test; and the object–memory evaluation (OME) developed by P. A. Fuld (1981). The sharpest distinction in performance among the groups was observed on the OME, and discriminant equations based on this test correctly classified at least 90% of the Ss. Study 2 applied the classification rules derived in the 1st investigation to an unselected series of 25 63–86 yr old geropsychiatry inpatients referred for neuropsychological evaluation. There was agreement between memory test classification and general categories of clinical discharge diagnosis (organic vs functional) for 21 of the Ss and with status at follow-up approximately 18 mo later. Predictive value computations suggested that the OME is more accurate in confirming true dementia than in detecting dementia syndromes associated with functional disorders. (45 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cognition and depression in a cohort of aging men: Results from the Western Collaborative Group Study.

Relationships between cognitive performance and self-ratings of depression on the Center for Epidemiologic Studies Depression scale (CES-D; L.S. Radloff, 1977) were examined for 1,217 older men. After controlling for demographic variables and both objective and subjective measures of health, significant associations were observed between several CES-D variables and measures of cognitive mental status, memory, and psychomotor speed. The Well-Being factor of the CES-D was the most robust predictor of cognitive scores. Therefore, for older adults with generally favorable health and socioeconomic resources, there may be a link between positive affect and maintenance of cognitive effectiveness. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Crystal Growth of Calcium Carbonate in Hydrogels as a Model of Biomineralization

In recent years, the prevalence of hydrogel‐like organic matrices in biomineralization has gained attention as a route to synthesizing a diverse range of crystalline structures. Here, examples of hydrogels in biological, as well as synthetic, bio‐inspired systems are discussed. Particular attention is given to understanding the physical versus chemical effects of a broad range of hydrogel matrices and their role in directing polymorph selectivity and morphological control in the calcium carbonate system. Finally, recent data regarding hydrogel‐matrix incorporation into the growing crystals is discussed and a mechanism for the formation of these single‐crystal composite materials is presented.     

Sex-appropriate toy preference and the ability to conceptualize toys as sex-role related.

In a study with 60 2-, 4-, and 6-yr-old boys and girls, girls showed increases in sex-appropriate preferences and correct identification with age. Boys' ability to identify toys as boys' or girls' also improved with age; however, their sex-appropriate toy preferences were consistently strong at all ages. In a 2nd study with 20 3-yr-old girls, Ss demonstrated sex-appropriate preferences only when first asked to identify toys as boys' or girls'. (6 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)