A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits

Regulators of G protein signaling (RGS) proteins act as GTPase-activating proteins (GAPs) toward the alpha subunits of heterotrimeric, signal-transducing G proteins. RGS11 contains a G protein gamma subunit-like (GGL) domain between its Dishevelled/Egl-10/Pleckstrin and RGS domains. GGL domains are also found in RGS6, RGS7, RGS9, and the Caenorhabditis elegans protein EGL-10. Coexpression of RGS11 with different Gbeta subunits reveals specific interaction between RGS11 and Gbeta5. The expression of mRNA for RGS11 and Gbeta5 in human tissues overlaps. The Gbeta5/RGS11 heterodimer acts as a GAP on Galphao, apparently selectively. RGS proteins that contain GGL domains appear to act as GAPs for Galpha proteins and form complexes with specific Gbeta subunits, adding to the combinatorial complexity of G protein-mediated signaling pathways.     

Thermal performance comparisons between passive solar and conventional housing in an Irish climate

The thermal performance of a passive solar house in Ireland having high energy conservation standards is compared with that of a similar sized conventional dwelling house. In both cases the performance over a meteorological Test Reference Year is assessed using climatically responsive models developed experimentally which predict their internal temperature without heating.

The results indicate that the conventional house required over three times as much auxiliary heating as the passive solar house. Solar gain accounted for over half the gross heat demand in the solar house compared to 13% in the bungalow. An added advantage of the increased utilization of solar gain was the estimated reduction in the heating season from nine to six months.     

Prophylactic efficacy of tilmicosin for bovine respiratory tract disease

The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates.     

丹江口水库汉江干流库区淤积分析

丹江口水库建成后,改变了天然河道的水沙输移条件,入库水沙受人工调度控制,进入了水库淤积重新造床过程,自建库至 2003 年,入库沙量 98 ％以上都淤积在库内,其中有 85 ％的淤积量都分布在干流库区内 , 出库的泥沙也都是异重流冲泻质。根据丹江口水库历史及近期资料,对汉江干流库区纵、横、垂 3 个方向的淤积分布进行了详细的分析研究,为三峡水库的运用提供良好的借鉴。     

新集三矿副井罐笼罐耳的改造

介绍副井罐笼罐耳磨损严重的原因 ,罐耳材质的选择及罐耳的改造方法。     

Simulation of AC spacecraft power systems

A technique is presented for modeling and simulating AC spacecraft power systems by combining all component models into an overall system model. Each component in the spacecraft power system is treated as a two-port network. A state model is written for each two-port network with the port voltages as the inputs. Each component state model is solved independently using the state transition matrix approach and assuming that its inputs are constant. The inputs to all components are then calculated using network analysis principles. As an example, a 20 kHz system is simulated using this approach, and the results are compared with those of a SPICE2 simulation     

The Role of Geographical Information Systems in Urban Hydrological Modelling

'Geographical information systems'(GIS) technology holds considerable benefits to urban hydrology because of the spatial nature of catchment analysis. The availability of a spatio-temporal database of catchment characteristics can eliminate the adoption of simplifying assumptions, which reduce the quality of a research study. This research study was undertaken to demonstrate the need for accurate spatial and temporal accounting of land-use in an urbanizing catchment. The definition of the extent of GIS use, the approach to its integration into a study, and spatial database development, are crucial for eventual success.     

Influence of environment on passive immunity in calves

Passive immunity in neonatal calves is influenced by environment. Placing newly born Holstein calves (108 head) in three different housing environments (shade, cooled shade, hutch) during hot weather produced differences in body temperature, serum cortocosteroids, immunoglobulin IgG1 concentrations, and mortality. Experimental design permitted examination of effects due to treatments, time, differences in colostrum, and climatic environment in an analysis of variance. Calves exposed to the hotter, less desirable environment responded by having a higher mortality, higher serum corticosteroid concentration, and lower serum immunoglobulin IgG1 at 2 and 10 days after birth. All of these were correlated. Calves that died had serum immunoglobulin IgG1 falling below the mean for all experimental calves.