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排序方式: 共有145条查询结果,搜索用时 15 毫秒
1.
Jineta Banerjee Mauricio D. Dorfman Rachael Fasnacht John D. Douglass Alice C. Wyse-Jackson Andres Barria Joshua P. Thaler 《International journal of molecular sciences》2022,23(12)
Both hypothalamic microglial inflammation and melanocortin pathway dysfunction contribute to diet-induced obesity (DIO) pathogenesis. Previous studies involving models of altered microglial signaling demonstrate altered DIO susceptibility with corresponding POMC neuron cytological changes, suggesting a link between microglia and the melanocortin system. We addressed this hypothesis using the specific microglial silencing molecule, CX3CL1 (fractalkine), to determine whether reducing hypothalamic microglial activation can restore POMC/melanocortin signaling to protect against DIO. We performed metabolic analyses in high fat diet (HFD)-fed mice with targeted viral overexpression of CX3CL1 in the hypothalamus. Electrophysiologic recording in hypothalamic slices from POMC-MAPT-GFP mice was used to determine the effects of HFD feeding and microglial silencing via minocycline or CX3CL1 on GFP-labeled POMC neurons. Finally, mice with hypothalamic overexpression of CX3CL1 received central treatment with the melanocortin receptor antagonist SHU9119 to determine whether melanocortin signaling is required for the metabolic benefits of CX3CL1. Hypothalamic overexpression of CX3CL1 increased leptin sensitivity and POMC gene expression, while reducing weight gain in animals fed an HFD. In electrophysiological recordings from hypothalamic slice preparations, HFD feeding was associated with reduced POMC neuron excitability and increased amplitude of inhibitory postsynaptic currents. Microglial silencing using minocycline or CX3CL1 treatment reversed these HFD-induced changes in POMC neuron electrophysiologic properties. Correspondingly, blockade of melanocortin receptor signaling in vivo prevented both the acute and chronic reduction in food intake and body weight mediated by CX3CL1. Our results show that suppressing microglial activation during HFD feeding reduces DIO susceptibility via a mechanism involving increased POMC neuron excitability and melanocortin signaling. 相似文献
2.
A. Sh. Dorfman V. K. Vishnevskii 《Journal of Engineering Physics and Thermophysics》1971,20(3):280-285
The equations of the boundary layer associated with non-Newtonian fluids obeying a rheological power law are integrated by a semiintegral method based on the simultaneous solution of the linearized equation of motion and the integral relationship.Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 20, No. 3, pp. 398–404, March, 1971. 相似文献
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A. M. Dorfman A. M. Lyakhovich V. I. Povstugar S. G. Bystrov 《Protection of Metals and Physical Chemistry of Surfaces》2000,36(3):258-263
A layer of hexamethyleniminem-nitrobenzoate was modified in low-temperature plasma on the air-oxidized iron surface. The composition and physicochemical properties of the modified inhibitor was studied by XPES and atomic force microscopy. It was assumed and then justified that the enhanced protective properties of a plasma-treated coating are due to the formation of corrosion-resistant iron nitrides and oxides, as well as new nitrogen- and oxygen-containing organic compounds with better inhibitive and adhesive abilities. Plasma-induced polymerization of the coating results in a high-strength, dense hydrophobic film that seems to be responsible for its enhanced barrier properties. 相似文献
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Time correlation functions for the transport coefficients in the linear Landau-Khalatnikov equations are derived on the basis of a formal theory. These Green-Kubo expressions are then explicitly evaluated for a dilute superfluid and the resulting transport coefficients are shown to be identical to those obtained previously by using a distribution function method. 相似文献
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A. L. Dorfman 《Journal of Engineering Physics and Thermophysics》1983,44(6):636-642
Results are presented from a study of the flow structure and mass transfer in a combustion chamber employing the microflame diffusion principle of combustion in a twisted flow. The study was conducted with an isothermal computational model. 相似文献
8.
Minc N Fütterer C Dorfman KD Bancaud A Gosse C Goubault C Viovy JL 《Analytical chemistry》2004,76(13):3770-3776
We present an experimental study of the microfluidic electrophoresis of long DNA in self-assembling matrixes of magnetic bead columns. Results are presented for the rapid separation of lambda-phage, 2lambda-DNA, and bacteriophage T4 DNA, where separation resolutions greater than 2 between lambda and T4 are achieved in times as short as 150 s. The use of a computer-piloted flow control system and injection results in high reproducibility between separations. We compare the experimentally measured mobility and dispersion with an exactly solvable lattice Monte Carlo model. The theory predicts that the mean velocity scales linearly with the field, the band broadening scales with the inverse of the field, and the resolution is independent of the field for intermediate fields-all of which are in accord with the experimental results. Moreover, reasonable quantitative agreement is achieved for band broadening for longer DNA (2lambda and T4) when the average postengagement time is measured experimentally. This work demonstrates the possibility of achieving fast microfluidic separation of large DNA on a routine basis. 相似文献
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The kinetic equations for a dilute superfluid developed previously are used to derive the Landau-Khalatnikov two-fluid hydrodynamic equations. Explicit expressions for the associated transport coefficients are given for very low temperatures and for moderately low temperatures. 相似文献