Revisiting the need for formal education in visualization.

Defining visualization education is still a work in progress. Visualization education is not just a subject within computer science. Computer scientists are not always the appropriate choice to teach visualization courses on their own. Visualization is not just mastering a set of concepts but acquiring skills. Student should learn by doing, either using one tool or a variety of tools, depending on the course's focus.     

Local calibration of rigid pavement performance models using resampling methods

The performance prediction models in the Pavement-ME design software are nationally calibrated using in-service pavement material properties, pavement structure, climate and truck loadings, and performance data obtained from the Long-Term Pavement Performance programme. The nationally calibrated models may not perform well if the inputs and performance data used to calibrate those do not represent the local design and construction practices. Therefore, before implementing the new M-E design procedure, each state highway agency (SHA) should evaluate how well the nationally calibrated performance models predict the measured field performance. The local calibrations of the Pavement-ME performance models are recommended to improve the performance prediction capabilities to reflect the unique conditions and design practices. During the local calibration process, the traditional calibration techniques (split sampling) may not necessarily provide adequate results when limited number of pavement sections are available. Consequently, there is a need to employ statistical and resampling methodologies that are more efficient and robust for model calibrations given the data related challenges encountered by SHAs. The main objectives of the paper are to demonstrate the local calibration of rigid pavement performance models and compare the calibration results based on different resampling techniques. The bootstrap is a non-parametric and robust resampling technique for estimating standard errors and confidence intervals of a statistic. The main advantage of bootstrapping is that model parameters estimation is possible without making distribution assumptions. This paper presents the use of bootstrapping and jackknifing to locally calibrate the transverse cracking and IRI performance models for newly constructed and rehabilitated rigid pavements. The results of the calibration show that the standard error of estimate and bias are lower compared to the traditional sampling methods. In addition, the validation statistics are similar to that of the locally calibrated model, especially for the IRI model, which indicates robustness of the local model coefficients.     

Site‐Selectively Coated,Densely‐Packed Microprojection Array Patches for Targeted Delivery of Vaccines to Skin

Densely packed dry‐coated microprojections are shown to deliver vaccines to targeted locations within the skin that are rich in immune cells, thus inducing protective immune responses against a lethal virus challenge. Selectively limiting the antigen coating to the tips of the projections, which penetrate the skin, would significantly reduce the amount of vaccine required in immunization. In this paper a simple technique, dip‐coating the microprojections, is introduced to meet this goal. By increasing the coating solution viscosity, an otherwise strong capillary action is mitigated and the desired controlled coating length on projections is achieved. Following application to the skin, most of the coated vaccine material is rapidly released from the projections (82.6% in mass within 2 min) to the target locations within the skin strata and a potent immune response is induced when a conventional influenza vaccine (Fluvax) is tested in a mouse model. The utility of this coating approach to a variety of molecules representative of vaccines (e.g., chicken egg ovalbumin (OVA) protein, DNA, and fluorescent dyes) is demonstrated. These collective attributes, together with the simplicity of the approach, position the dip‐coating method for practical utility in large vaccination campaigns.     

Theoretical and numerical aspects of transmit SENSE

The ideas of parallel imaging techniques, designed to shorten the acquisition time by the simultaneous use of multiple receive coils, can be adapted for parallel transmission of a spatially selective multidimensional RF pulse. In analogy to data acquisition, a multidimensional RF pulse follows a certain trajectory in k-space. Shortening this trajectory shortens the pulse duration. The use of multiple transmit coils, each with its own time-dependent waveform and spatial sensitivity, compensates for the missing parts of k-space. This results in a maintained spatial definition of the pulse profile while its duration is reduced. This paper describes the basic equations of parallel transmission with arbitrarily shaped transmit coils ("Transmit SENSE") focusing on two-dimensional RF pulses. Results of numerical studies are presented demonstrating the theoretical feasibility of the approach.     

Design of repeat-accumulate codes for iterative detection and decoding

Extrinsic information transfer (EXIT) charts are used to design systematic and nonsystematic repeat-accumulate (RA) codes for iterative detection and decoding. The convergence problems of nonsystematic RA codes are solved by introducing a biregular, or doped, layer of check nodes. As examples, such nonsystematic codes are designed for multi-input/multi-output (MIMO) fading channels and are shown to operate close to capacity.     

A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self‐adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self‐assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solution. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic components. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid_632‐651 and ovalbumin_323‐339 drive antigen‐specific responses both in vitro and in vivo, eliciting both CD4⁺ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemagglutinin_518‐526 from the influenza virus are also able to drive a CD8⁺ T cell response in vivo. This work demonstrates the potential of SAGEs to act as a modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.     

Design of low-density parity-check codes for modulation and detection

A coding and modulation technique is studied where the coded bits of an irregular low-density parity-check (LDPC) code are passed directly to a modulator. At the receiver, the variable nodes of the LDPC decoder graph are connected to detector nodes, and iterative decoding is accomplished by viewing the variable and detector nodes as one decoder. The code is optimized by performing a curve fitting on extrinsic information transfer charts. Design examples are given for additive white Gaussian noise channels, as well as multiple-input, multiple-output (MIMO) fading channels where the receiver, but not the transmitter, knows the channel. For the MIMO channels, the technique operates within 1.25 dB of capacity for various antenna configurations, and thereby outperforms a scheme employing a parallel concatenated (turbo) code by wide margins when there are more transmit than receive antennas.     

Detect and avoid: an ultra-wideband/WiMAX coexistence mechanism [Topics in Radio Communications]

Cognitive radios have been advanced as a technology for the opportunistic use of underutilized spectrum wherein secondary devices sense the presence of the primary user and use the spectrum only if it is deemed empty. Spectral cognition of this form can also be used by regulators to facilitate the dynamic coexistence of different service types. An example of this is the operation of ultra-wideband devices in WiMAX bands: UWB devices must detect and avoid WiMAX devices in certain regulatory domains. In this article we start by discussing various options for detection and avoidance. We then describe the obstacles faced in achieving robust detection and avoidance with an on-chip implementation of basic DAA functionality. Finally, we present measurement results for operation of a single UWB device with a WiMAX system. This interaction also highlights the problem of dealing with listen before speak primaries where secondary transmission could interfere by blocking the primary's access to the medium.     

Iterative demapping for QPSK modulation

The authors present an iterative decoding scheme which is particularly suited for quadrature phase shift keying (QPSK) modulation with anti-Gray mapping. At the receiver, a soft demapper accepting a priori information and a convolutional decoder are applied in a serial concatenation. Numerical results are presented for QPSK in additive white Gaussian noise and Rayleigh-fading channels. The iterated system applying anti-Gray mapping outperforms the conventional system using Gray mapping after only one iteration