Diagnosis and epidural hematoma by brain scan and perfusion study: case report

By using the arterial and venous phases of an anterior cerebral perfusion study, which showed downward displacement of the sagittal sinus, and the finding of a "rim" on the delayed scans, the specific diagnosis of epidural hematoma was established.     

利用无桥式技术提供更高效率的功率因数修正器

国际整流器公司交流转直流应用部门的Ron Brown与Marco Soldano,利用周期控制技术(one-cycle control)来实现更高效率的无桥式功率因数修正器的设计. 最近,无桥式升压型功率因数修正器线路,获得了很多关注的焦点.借助移除传统转换器其输入级的桥式整流器,切换损失可以降低,而使设计者设计出更高的效率.尤有甚者,无桥式的方法可以避免因导通损,而降低效率,这种现象特别是出现在低的输入电压,其根本的原因是二极管整流器的顺向导通压降.最后,无桥式设计具有先天上更简单,需要更少器件的优点.     

Genome-Wide Investigation of Multifocal and Unifocal Prostate Cancer—Are They Genetically Different?

Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.     

IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. Correlation with induction of Bcl-2

Most studies of apoptosis on T lymphocytes have examined the effects of various stimuli on immature T cells from the thymus. Previous work has indicated that apoptosis of mature memory T cells may be an important pathophysiologic mechanism in diseases such as AIDS, cancer, and autoimmunity. The effect of IL-2 on apoptosis of T cells is not clear. Therefore, we studied the ability of IL-2 to rescue Ag-specific T cells from apoptosis. We found that IL-2, in a dose-dependent manner, prevented T cells from entering apoptosis induced by gamma-irradiation, mitomycin C, or dexamethasone. This effect was specific for IL-2; IL-1 beta, IL-6, or IFN-gamma could not reproduce it. In contrast to Ag-specific T cells, immature T cells and naive mature peripheral T cells could not be rescued by IL-2 from radiation-induced apoptosis. Apoptosis rescue by IL-2 was associated with the induction of bcl-2 mRNA and protein. This induction could not be attributed to the effects of IL-2 on the cell cycle, as T cells that were prevented from cell cycle progression by irradiation showed a similar induction of bcl-2. Rescued cells retained their Ag-specific proliferative capacity and in vivo functions. These findings demonstrate that the apoptotic death of Ag-specific T cell lines, cells which can be regarded as a model for memory T cells, can be prevented with IL-2. This effect may have important therapeutic implications for patients receiving chemotherapy or radiotherapy, and for patients with AIDS who develop immunodeficiency primarily as a result of loss of Ag-specific memory T cells.     

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the TEL pointed (PNT) domain to (i) the JAK2 JH1-kinase domain, (ii) part of and (iii) all of the JH2 pseudokinase domain. We report that all of the human TEL/JAK2 variants, and a human/mouse chimeric hTEL/mJAK2(JH1) fusion gene, transform the interleukin-3 (IL-3)-dependent murine hematopoietic cell line Ba/F3 to IL-3-independent growth. Transformation requires both the TEL PNT domain and JAK2 kinase activity. Furthermore, all TEL/JAK2 variants strongly activated STAT 5 by phosphotyrosine Western blots and by electrophoretic mobility shift assays (EMSA). Mice (n = 40) transplanted with bone marrow infected with the MSCV retrovirus containing either the hTEL/mJAK2(JH1) fusion or its human counterpart developed a fatal mixed myeloproliferative and T-cell lymphoproliferative disorder with a latency of 2-10 weeks. In contrast, mice transplanted with a TEL/JAK2 mutant lacking the TEL PNT domain (n = 10) or a kinase-inactive TEL/JAK2(JH1) mutant (n = 10) did not develop the disease. We conclude that all human TEL/JAK2 fusion variants are oncoproteins in vitro that strongly activate STAT 5, and cause lethal myelo- and lymphoproliferative syndromes in murine bone marrow transplant models of leukemia.     

Modified radial head--capitellum projection in elbow trauma

A new technique is described for evaluating trauma to the elbow. The modified radial head--capitellum view is an alternative radiological projection to that described by Greenspan and Norman (the radial head--capitellum view). This new projection is useful in demonstrating minimally displaced or non-displaced fractures of the radial head, capitellum and coronoid process.     

Potenzial des IR Micro‐Imaging zur In‐situ‐Untersuchung chemischer Reaktionen in nanoporösen Katalysatoren

The in‐situ study of chemical reactions is an intensively studied research topic. A suitable method for this investigation is the IR micro‐imaging technique, which allows to record space‐ and time‐resolved IR spectra. The preparation of a suitable model system with a 3D pore system for the in‐situ recording of concentration profiles using IR micro‐imaging is described, enabling the space‐ and time‐resolved monitoring of catalytic reactions in nanoporous catalysts for the first time. The model system consists of a nanoporous glass monolith with gas‐tight sealed outer surface, therefore, enabling the recording of concentration profiles of cyclohexane and cyclohexane‐benzene mixtures as a function of time.     

To Be or Not to Be Electronic Money, That's the Question

The European Electronic Money Directive contains a definition of electronic money. However, determining which systems involving the use of electronic value fall under its scope can be more complicated than one might think. This issue is explored in this article through consideration of the question of whether prepaid mobile phone credits qualify as electronic money—a question that is currently being debated by telecommunications operators and regulators.