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1.
Silver Nanoflower Decorated Graphene Oxide Sponges for Highly Sensitive Variable Stiffness Stress Sensors 下载免费PDF全文
Fakhre Alam Khan C. Muhammed Ajmal Seonghyun Bae Sungwon Seo Hyungpil Moon Seunghyun Baik 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(24)
Soft conductive materials should enable large deformation while keeping high electrical conductivity and elasticity. The graphene oxide (GO)‐based sponge is a potential candidate to endow large deformation. However, it typically exhibits low conductivity and elasticity. Here, the highly conductive and elastic sponge composed of GO, flower‐shaped silver nanoparticles (AgNFs), and polyimide (GO‐AgNF‐PI sponge) are demonstrated. The average pore size and porosity are 114 µm and 94.7%, respectively. Ag NFs have thin petals (8–20 nm) protruding out of the surface of a spherical bud (300–350 nm) significantly enhancing the specific surface area (2.83 m2 g?1). The electrical conductivity (0.306 S m?1 at 0% strain) of the GO‐AgNF‐PI sponge is increased by more than an order of magnitude with the addition of Ag NFs. A nearly perfect elasticity is obtained over a wide compressive strain range (0–90%). The strain‐dependent, nonlinear variation of Young's modulus of the sponge provides a unique opportunity as a variable stiffness stress sensor that operates over a wide stress range (0–10 kPa) with a high maximum sensitivity (0.572 kPa?1). It allows grasping of a soft rose and a hard bottle, with the minimal object deformation, when attached on the finger of a robot gripper. 相似文献
2.
Jing Yuan Tan Muhammed Haiqal Low Yunxin Chen Francesca Lorraine Wei Inng Lim 《International journal of molecular sciences》2022,23(13)
Chimeric antigen receptor (CAR) T cell therapy has ushered in a new era in cancer treatment. Remarkable outcomes have been demonstrated in patients with previously untreatable relapsed/refractory hematological malignancies. However, optimizing efficacy and reducing the risk of toxicities have posed major challenges, limiting the success of this therapy. The tumor microenvironment (TME) plays an important role in CAR T cell therapy’s effectiveness and the risk of toxicities. Increasing research studies have also identified various biomarkers that can predict its effectiveness and risk of toxicities. In this review, we discuss the various aspects of the TME and biomarkers that have been implicated thus far and discuss the role of creating scoring systems that can aid in further refining clinical applications of CAR T cell therapy and establishing a safe and efficacious personalised medicine for individuals. 相似文献
3.
Muhammed Iraqi Avishay Edri Yariv Greenshpan Oron Goldstein Noa Ofir Priyanka Bolel Muhammad Abu Ahmad Miri Zektser Kerry S. Campbell Ory Rouvio Roi Gazit Angel Porgador 《International journal of molecular sciences》2022,23(9)
Simple SummaryMembrane-associated PCNA is expressed on the surface of human MM cell lines and primary MM cells. Mab 14-25-9 interacts with membrane-associated PCNA and blocks its binding to NK-expressed NKp44, thus activating NK function. We showed that mAb 14-25-9 can serve as an immune checkpoint blocker, enhancing the function of NK cells on target human MM cell lines and primary cells.AbstractMultiple Myeloma (MM) is a devastating malignancy that evades immune destruction using multiple mechanisms. The NKp44 receptor interacts with PCNA (Proliferating Cell Nuclear Antigen) and may inhibit NK cells’ functions. Here we studied in vitro the expression and function of PCNA on MM cells. First, we show that PCNA is present on the cell membrane of five out of six MM cell lines, using novel anti-PCNA mAb developed to recognize membrane-associated PCNA. Next, we stained primary bone marrow (BM) mononuclear cells from MM patients and showed significant staining of membrane-associated PCNA in the fraction of CD38+CD138+ BM cells that contain the MM cells. Importantly, blocking of the membrane PCNA on MM cells enhanced the activity of NK cells, including IFN-γ-secretion and degranulation. Our results highlight the possible blocking of the NKp44-PCNA immune checkpoint by the mAb 14-25-9 antibody to enhance NK cell responses against MM, providing a novel treatment option. 相似文献
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Abu Syed H. Kabir Xinjin Cao Javad Gholipour Priti Wanjara Jonathan Cuddy Anand Birur Mamoun Medraj 《Metallurgical and Materials Transactions A》2012,43(11):4171-4184
The effects of postweld heat treatment (PWHT) on 3.2-mm- and 5.1-mm-thick Ti-6Al-4V butt joints welded using a continuous wave (CW) 4-kW Nd:YAG laser welding machine were investigated in terms of microstructural transformations, welding defects, and hardness, as well as global and local tensile properties. Two postweld heat treatments, i.e., stress-relief annealing (SRA) and solution heat treatment followed by aging (STA), were performed and the weld qualities were compared with the as-welded condition. A digital image correlation technique was used to determine the global tensile behavior for the transverse welding samples. The local tensile properties including yield strength and maximum strain were determined, for the first time, for the laser-welded Ti-6Al-4V. The mechanical properties, including hardness and the global and local tensile properties, were correlated to the microstructure and defects in the as-welded, SRA, and STA conditions. 相似文献
6.
随着安全关键系统对计算性能要求的日趋提高,能够提供更强计算能力而又减少电子设备的体积、重量和功耗的多核处理器将在安全关键领域得到广泛应用.同步语言能够表达确定性并发行为且具有精确时间语义等特性,适用于安全关键软件的建模和验证.目前,同步语言SIGNAL编译器主要支持串行代码生成,较少关注多线程代码生成.提出一种同步语言SIGNAL多线程代码生成工具.首先将SIGNAL程序转换为经过时钟演算的S-CGA中间程序;之后将S-CGA中间程序转换为时钟数据依赖图以分析依赖关系;然后对时钟数据依赖图进行拓扑排序划分,并针对划分结果提出优化算法和基于流水线方式的任务划分方法;最后将划分结果转换为虚拟多线程结构并进一步生成可执行多线程C/Java代码.通过在多核处理器上的实验,验证了所提方法的有效性. 相似文献
7.
Süleyman Karda Serkan elik Muhammed Ali Bingl Mehmet Sabir Kiraz Hüseyin Demirci Albert Levi 《Wireless Communications and Mobile Computing》2015,15(18):2150-2166
This paper examines Vaudenay's privacy model, which is one of the first and most complete privacy models that featured the notion of different privacy classes. We enhance this model by introducing two new generic adversary classes, k‐strong and k‐forward adversaries where the adversary is allowed to corrupt a tag at most k times. Moreover, we introduce an extended privacy definition that also covers all privacy classes of Vaudenay's model. In order to achieve highest privacy level, we study low cost primitives such as physically unclonable functions (PUFs). The common assumption of PUFs is that their physical structure is destroyed once tampered. This is an ideal assumption because the tamper resistance depends on the ability of the attacker and the quality of the PUF circuits. In this paper, we have weakened this assumption by introducing a new definition k‐resistant PUFs. k‐PUFs are tamper resistant against at most k attacks; that is, their physical structure remains still functional and correct until at most kth physical attack. Furthermore, we prove that strong privacy can be achieved without public‐key cryptography using k PUF‐based authentication. We finally prove that our extended proposal achieves both reader authentication and k‐strong privacy. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
8.
In recent year, new nanocomposite electrolytes materials have been developed for low-temperature ceramic fuel cells (CFCs). To further improve the performance of CFCs based on the nanocomposite electrolyte, compatible active anode with sufficient low polarizations is needed. To improve the performance of anode, i.e. to enlarge tripe phase boundaries (TPB), anode materials with both porous structure and phase homogeneity of metal and ceramic are preferred. In the present study, we developed a novel microwave-assisted template-, surfactant-free synthesis route for mesoporous CuO–Ce0.8Sm0.2O2−δ composite anode by homogeneous precipitation of microspherical precursor in aqueous solutions followed by calcination. The composite anode sample was characterized by thermogravimetry analysis, X-ray diffraction, SEM, EDX, etc. The characterization results indicated that CuO–SDC composite anode with mesoporous structure was prepared and both SDC and CuO phases were homogenously distributed. Fuel cells have been constructed using as-prepared composite as anodes and lithiated NiO as cathode based on the SDC–carbonate nanocomposite electrolyte. Fuel cell performance tests indicated that the cell with mesoporous Cu–SDC anode had better performance than conventional Cu–SDC anode prepared by solid-state method. 相似文献
9.
Ying Ma Xiaodi Wang Rizwan Raza Mamoun Muhammed Bin Zhu 《International Journal of Hydrogen Energy》2010
The novel core–shell nanostructured SDC/Na2CO3 composite has been demonstrated as a promising electrolyte material for low-temperature SOFCs. However, as a nanostructured material, stability might be doubted under elevated temperature due to their high surface energy. So in order to study the thermal stability of SDC/Na2CO3 nanocomposite, XRD, BET, SEM and TGA characterizations were carried on after annealing samples at various temperatures. Crystallite sizes, BET surface areas, and SEM results indicated that the SDC/Na2CO3 nanocomposite possesses better thermal stability on nanostructure than pure SDC till 700 °C. TGA analysis verified that Na2CO3 phase exists steadily in the SDC/Na2CO3 composite. The performance and durability of SOFCs based on SDC/Na2CO3 electrolyte were also investigated. The cell delivered a maximum power density of 0.78 W cm−2 at 550 °C and a steady output of about 0.62 W cm−2 over 12 h operation. The high performances together with notable thermal stability make the SDC/Na2CO3 nanocomposite as a potential electrolyte material for long-term SOFCs that operate at 500–600 °C. 相似文献
10.
Muhammed Uludağ 《Dynamical Systems: An International Journal》2018,33(3):497-518
We explore the dynamics of a 1-parameter family of continued fraction maps of the unit interval. The family contains as special instances the Gauss continued fraction map and the Fibonacci map. We determine the transfer operators of these dynamical maps and prove that the Denjoy–Minkowski measure is a common invariant measure of the family. We show that their analytic invariant measures obey a common functional equation generalizing Lewis’ functional equation and we find a.c. invariant measures for some members of the family. We also discuss a certain involution of this family which sends the Gauss map to the Fibonacci map relating Riemann's zeta function to the so-called Fibonacci zeta function. 相似文献