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The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients 总被引:2,自引:0,他引:2
Sushil K. Jain Robert McVie John J Jaramillo Melissa Palmer Tiney Smith Z. D. Meachum Rufus L. Little 《Lipids》1996,31(1):S87-S90
Among many factors, elevated lipids and lipid peroxide levels in blood are major risk factors in the development of cardiovascular
disease in diabetic patients. This study has examined whether oral supplementation of vitamin E, an antioxidant, has any effect
on blood lipid peroxidation products (LP) and lipid profile of diabetic patients. Thirty-five diabetics(D) were supplemented
withdl-α-tocopherol (E) capsule (orally, 100 IU/d) or placebo (P) for three months in double-blind clinical trials. Plasma E was
analyzed by HPLC and LP by the thiobarbituric acid-reactivity; serum lipids by auto-analyzer. Data were analyzed using pairedt-test and Wilcoxon Signed Rank Test. Vitamin E supplementation significantly lowered LP and lipid levels in diabetic patients;
there were no differences in these parameters after P supplementation. There were no differences in the duration of diabetes
and ages of D between P-and E-supplemented groups. This study suggests that vitamin E supplementation significantly lowers
blood LP and lipid levels in diabetic patients. 相似文献
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The present experiments examined whether behavioral conditioned responses (CRs) develop to lithium chloride (LiCl)-paired tastes and whether these CRs are similar to the behaviors that follow administration of the drug. Rats were exposed to a saccharin solution via intraoral infusions before being injected with either LiCl or saline. CRs were assessed after conditioning when the saccharin conditioned stimulus (CS) was delivered alone. The unconditioned response (UCR) to LiCl delivery is a very distinctive posture that has been termed "lying-on-belly." The present study indicates that this behavior pattern also occurs after the delivery of a LiCl-paired taste solution. The similarity between these unconditioned and conditioned behaviors is consistent with the hypothesis that responses are conditioned during taste aversion acquisition and that CRs are similar to those that are generated by the drugs used in conditioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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