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Cold forming generally allows the fast generation of parts with very low tolerances. In addition, mechanical properties are improved, if work hardening materials are used. Transferring the cold forming process to micro range leads to a decrease in the maximum achievable upset ratio so that the forming process becomes inefficient. Therefore, a laser-based free form heading process has been developed to generate preforms which can be calibrated in a secondary cold forming step. The achievable upset ratios reach values of several hundreds instead of 2.1 which is common for single step mechanical upsetting. In this article, heat losses arising in the material accumulation process using laser-based free form heading are analyzed and discussed. For this purpose, the process is modeled within the framework of continuum mechanics and simulated by a finite element method. By using a numerical approach, a systematic study on heat losses is performed in order to identify the influence of radiation, heat transfer due to convection and thermal conduction during laser irradiation time. The simulation results, which are validated with experimental data, show that the radiation is the most important mechanism reducing the efficiency of the accumulation process. 相似文献
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Declerck Nathalie; Machius Mischa; Joyet Philippe; Wiegand Georg; Huber Robert; Gaillardin Claude 《Protein engineering, design & selection : PEDS》2003,16(4):287-293
Bacillus licheniformis 相似文献
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During processing of so‐called true flat shadow/masks made of Invar steel for large size TV screens the mask is stretched onto a solid frame. Mask and frame are submitted to a final heat treatment (blackening treatment) in order to enhance the emissivity of the material. Elevated temperatures and pretension makes the mask material prone to plastic straining, resulting in disutility of the unit for the application. From a technological point of view, the material behaviour under these conditions has been defined as short time creep behaviour. The mechanisms causing creep in this special case are not fully understood. Focus of the present work was the examination of the effect of cube twins on the short time creep behaviour of the investigated Invar steel by texture analysis using EBSD technology. This investigation was conducted under four different material conditions covering a whole set of production steps during shadowmask processing. Detailed information about the change of the volume fractions and the orientation of characteristic texture components, most of all the cube twins, could be gained. The observations revealed that during the creep test two types of cube twins make an orientation change, thus plastic deformation takes place, causing relaxation of the material. The observation of cube twin rotation during the creep test is partly confirmed by the simulation of the respective Taylor factors. 相似文献
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Mischa Bechberger 《Refocus》2003,4(5):30-34
The goal of increasing the share of renewable energy sources (RES) in total primary energy supply (TPES) as well as in electricity production in an enlarged European Union (EU-28) will be a challenging one and most likely will be addressed by a mix of promotion instruments. Mischa Bechberger and Danyel Reiche take a look at the implications for renewables in an enlarged EU.The most prominent policies in the case of electricity are renewable energy feed-in tariffs (REFIT) and quota systems, but also others like tenders, energy tax exemptions, and environmental funds in the form of investment subsidies, and soft loans are playing a part. 相似文献
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Polylactide‐block‐Polypeptide‐block‐Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release
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Robert Dorresteijn Nils Billecke Mischa Schwendy Sabine Pütz Mischa Bonn Sapun H. Parekh Markus Klapper Klaus Müllen 《Advanced functional materials》2014,24(26):4026-4033
A versatile nanoparticle system is presented in which drug release is triggered by enzymatic polymer cleavage, resulting in a physicochemical change of the carrier. The polylactide‐block‐peptide‐block‐polylactide triblock copolymer is generated by initiation of the ring‐opening polymerization of L‐lactide with a complex bifunctional peptide having an enzymatic recognition and cleavage site (Pro‐Leu‐Gly‐Leu‐Ala‐Gly). This triblock copolymer is specifically bisected by matrix metalloproteinase‐2 (MMP‐2), an enzyme overexpressed in tumor tissues. Triblock copolymer nanoparticles formed by nonaqueous emulsion polymerization are readily transferred into aqueous media without aggregation, even in the presence of blood serum. Cleavage of the triblock copolymer leads to a significant decrease of the glass transition temperature (Tg) from 39 °C to 31 °C, likely mediating cargo release under physiological conditions. Selective drug targeting is demonstrated by hampered mitosis and increased cell death resulting from drug release via MMP‐2 specific cleavage of triblock copolymer carrier. On the contrary, nanocarriers having a scrambled (non‐recognizable) peptide sequence do not cause enhanced cytotoxicity, demonstrating the enzyme‐specific cleavage and subsequent drug release. The unique physicochemical properties, cleavage‐dependent cargo release, and tunability of carrier bioactivity by simple peptide exchange highlight the potential of this polymer‐nanoparticle concept as platform for custom‐designed carrier systems. 相似文献
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Mischa Schmidt Jan Seedorf Stefano Napolitano Rosario G. Garroppo Andrea Cavaliere Thilo Ewald Armin Jahanpanah Zbigniew Kopertowski Marcin Pilarski Pawel Grochocki 《Peer-to-Peer Networking and Applications》2013,6(2):134-154
Application Layer Traffic Optimization (ALTO) has recently gained attention in the research and standardisation community as a way for a network operator to guide the peer selection process of distributed applications by providing network layer topology information. In particular P2P applications are expected to gain from ALTO, due to the many connections peers form among each other, often without taking network layer topology information into account. In this paper, we present results of an extensive intra-ISP trial with an ALTO-enhanced P2P filesharing software. In summary, our results show that—depending on the concrete setting and on the distribution of upload capacity in the network—ALTO enables an ISP to save operational costs significantly while not degrading application layer performance noticeably. In addition, based on our experience we are able to give advice to operators on how to save costs with ALTO while not sacrificing application layer performance at all. 相似文献
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Trinh MT Polak L Schins JM Houtepen AJ Vaxenburg R Maikov GI Grinbom G Midgett AG Luther JM Beard MC Nozik AJ Bonn M Lifshitz E Siebbeles LD 《Nano letters》2011,11(4):1623-1629
Multiple exciton generation (MEG) in PbSe quantum dots (QDs), PbSe(x)S(1-x) alloy QDs, PbSe/PbS core/shell QDs, and PbSe/PbSe(y)S(1-y) core/alloy-shell QDs was studied with time-resolved optical pump and probe spectroscopy. The optical absorption exhibits a red-shift upon the introduction of a shell around a PbSe core, which increases with the thickness of the shell. According to electronic structure calculations this can be attributed to charge delocalization into the shell. Remarkably, the measured quantum yield of MEG, the hot exciton cooling rate, and the Auger recombination rate of biexcitons are similar for pure PbSe QDs and core/shell QDs with the same core size and varying shell thickness. The higher density of states in the alloy and core/shell QDs provide a faster exciton cooling channel that likely competes with the fast MEG process due to a higher biexciton density of states. Calculations reveal only a minor asymmetric delocalization of holes and electrons over the entire core/shell volume, which may partially explain why the Auger recombination rate does not depend on the presence of a shell. 相似文献
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