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OL Lopez RP Brenner JT Becker RF Ulrich F Boller ST DeKosky 《Canadian Metallurgical Quarterly》1997,48(6):1521-1525
We examined whether either psychotic features (e.g., delusions and hallucinations) or EEG abnormalities are associated with more rapid progression of Alzheimer's disease (AD). AD patients with psychosis have exhibited more EEG abnormalities than those without psychosis, and both abnormal EEG and psychosis have been noted to be predictors of functional and cognitive decline in AD. Ninety-five probable AD patients participating in a longitudinal study of dementia had an EEG and a semistructured psychiatric interview at baseline. Using EEG spectral analysis, we classified records as normal/abnormal based on the parasagittal mean frequency. Patients with abnormal EEGs were more functionally (e.g., Blessed Rating Scale for activities of daily living) and cognitively (e.g., Mini-Mental State) impaired than patients with normal EEG. AD patients with psychosis were only more functionally impaired than patients without psychosis. A two-factor analysis showed no interaction between abnormal EEG and psychosis. In addition, using a Cox proportional hazard model adjusted for age and education, the presence of an abnormal EEG or psychotic symptom at study entry was associated with higher risk of reaching severe cognitive and functional impairment during follow-up. Neither abnormal EEG nor the presence of psychosis predicted death. These results indicate that both abnormal EEG and psychosis are independent predictors of disease progression but not of physical survival. 相似文献
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Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells. 相似文献
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Hans-Jürgen Odenthal Herbert Pfeifer Ina Lemanowicz Rainer Gorissen 《Metallurgical and Materials Transactions B》2002,33(2):163-172
The present work describes quantitative digital particle image velocimetry measurements of a full-scale water model of a thin
slab mold. Different casting speeds and two submerged entry nozzles with one and two outlet ports have been investigated.
The flow pattern of the single-port nozzle shows a counterclockwise-rotating double vortex that is nearly steady-state but
leads to high stationary surface waves. The flow jets out of the two-port nozzle oscillate and produce a transient flow pattern
with low wave amplitudes. The amplitudes for the one-port nozzle show a linear variation with the volumetric flow rate. The
experimental results lead to a good interpretation of the flow phenomena and are used to validate steady-state numerical simulations
with the commercial program, CFX, on the basis of the Reynolds equations. To describe anisotropic turbulence effects, the
Reynolds stress model (RSM) is used for the flat single-port nozzle and the standard k-ɛ model for the mold flow. The calculated mean velocities and wave amplitudes, predicted from pressure distribution at the
water surface, are generally in the consensus of the experimental data.
An erratum to this article is available at . 相似文献
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The vicissitudes of the Israeli-Palestinian peace process since 1967 are analyzed using attitudes and related concepts where relevant. The 1967 war returned the two peoples' zero-sum conflict around national identity to its origin as a conflict within the land both peoples claim. Gradually, new attitudes evolved regarding the necessity and possibility of negotiations toward a two-state solution based on mutual recognition, which became the building stones of the 1993 Oslo agreement. Lacking a commitment to a final outcome, the Oslo-based peace process was hampered by reserve options, which increased avoidance at the expense of approach tendencies as the parties moved toward a final agreement. The resulting breakdown of the process in 2000 produced clashing narratives, reflecting different anchors for judgment and classical mirror images. Public support for violence increased, even as public opinion continued to favor a negotiated two-state solution. Reviving the peace process requires mutual reassurance about the availability of a partner for negotiating a principled peace based on a historic compromise that meets the basic needs and validates the identities of both peoples. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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