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1.
Shevtsova L. I. Korchagin M. A. Esikov M. A. Lozhkin V. S. Gavrilov A. I. Larichkin A. Yu. 《Metallurgist》2022,65(11-12):1273-1280
Metallurgist - The paper described the structure and mechanical properties of nickel aluminide (Ni3Al) obtained by spark plasma sintering of the two compositions of nickel and aluminum powder... 相似文献
2.
Sergey O. Bachurin Elena F. Shevtsova Galina F. Makhaeva Alexey Yu. Aksinenko Vladimir V. Grigoriev Tatiana V. Goreva Tatiana A. Epishina Nadezhda V. Kovaleva Natalia P. Boltneva Sofya V. Lushchekina Elena V. Rudakova Darya V. Vinogradova Pavel N. Shevtsov Elena A. Pushkareva Ludmila G. Dubova Tatiana P. Serkova Ivan M. Veselov Vladimir P. Fisenko Rudy J. Richardson 《International journal of molecular sciences》2022,23(22)
The development of multi-target-directed ligands (MTDLs) would provide effective therapy of neurodegenerative diseases (ND) with complex and nonclear pathogenesis. A promising method to create such potential drugs is combining neuroactive pharmacophoric groups acting on different biotargets involved in the pathogenesis of ND. We developed a synthetic algorithm for the conjugation of indole derivatives and methylene blue (MB), which are pharmacophoric ligands that act on the key stages of pathogenesis. We synthesized hybrid structures and performed a comprehensive screening for a specific set of biotargets participating in the pathogenesis of ND (i.e., cholinesterases, NMDA receptor, mitochondria, and microtubules assembly). The results of the screening study enabled us to find two lead compounds (4h and 4i) which effectively inhibited cholinesterases and bound to the AChE PAS, possessed antioxidant activity, and stimulated the assembly of microtubules. One of them (4i) exhibited activity as a ligand for the ifenprodil-specific site of the NMDA receptor. In addition, this lead compound was able to bypass the inhibition of complex I and prevent calcium-induced mitochondrial depolarization, suggesting a neuroprotective property that was confirmed using a cellular calcium overload model of neurodegeneration. Thus, these new MB-cycloalkaneindole conjugates constitute a promising class of compounds for the development of multitarget neuroprotective drugs which simultaneously act on several targets, thereby providing cognitive stimulating, neuroprotective, and disease-modifying effects. 相似文献
3.
4.
Utepov E. B. Pototskii E. P. Shevtsova V. S. Kattabekov E. N. Abuova R. Zh. Berkinbaeva A. S. 《Metallurgist》2019,63(3-4):286-294
Metallurgist - Steels alloyed with chromium are used for the first time for manufacturing sheet stacker components. Steel with a high chromium content (45X), exhibiting good damping properties,... 相似文献
5.
M. I. Mazuritsky A. V. Soldatov V. L. Lyashenko E. M. Latush A. T. Kozakov S. I. Shevtsova A. Marcelli 《Technical Physics Letters》2001,27(1):11-13
An electron-probe X-ray microanalyzers, the characteristic X-ray radiation is generated within a small volume of sample and the emitting surface area is on the order of 1 μm2. For a distance to analyzer of approximately 0.5 m, this small emitting area can be considered as a point source. Practical implementations of the electron-probe X-ray microanalysis (EPMA) require a high spectral resolution and sufficient intensity. 相似文献
6.
Khotimchenko IuS Khasina EI Kovalev VV Shevtsova OI Shestakova SV 《Voprosy pitaniia》2000,69(1-2):22-26
The efficiency of some polysaccharides was investigated in mice with an experimental toxic hepatitis. Hepatitis was induced by the oral administration of 10% solution CCl4 in olive oil at a dosage of 3 ml/kg body weight every day during 7 days. After that tested substances were administrated every day 30-40 min before a feeding at a dosage of 150 mg/kg body weight during 14-21 days. Results showed that a calcium alginate, two low-methoxyl pectins (one with the degree of esterification about 50% and other with the degree of esterification less 5%), fucoidan, and chitozan, but not lambda-carrageenan and kappa-carrageenan, have beneficial affects on liver total lipid, glycogen, malondialdehyde, and diene conjugates as well as on blood total lipid and alanine aminotransferase activity in animals with experimental toxic hepatitis. 相似文献
7.
Heat Transfer Through the Interface and Flow Regimes in Liquid Bridge Subjected to Co-Axial Gas Flow
We present results of an extensive numerical study on the thermocapillary (Marangoni) convection and a heat transfer through the interface in a liquid bridge of Pr?=?68. The geometry of the physical problem is a cylindrical and non-deformable liquid bridge concentrically surrounded by an annular gas channel under conditions of zero gravity. The gas flow is co- or counter-directed with respect to the Marangoni flow. The forced gas flow along the interface provides two actions: via shear stresses and heat exchange. Usually the cooling of the interface enhances the flow while the heating slows down. This general trend may not hold when shear and thermocapillary stresses are comparable. The results show that when gas enters from the cold side the heat transfer through the interface is considerably larger than that when gas enters from the hot side. 相似文献
8.
Lev A. Slobozhanin Valentina M. Shevtsova J. Iwan D. Alexander José Meseguer José M. Montanero 《Microgravity science and technology》2012,24(2):65-77
This paper reviews the dynamics of breaking or oscillating axisymmetric liquid bridges, and estimates of the energy which
is needed to break a liquid bridge. We consider a liquid bridge spanning two coaxial equal disks with sharp edges and held
by surface-tension forces. The liquid volume is assumed to be conserved under perturbations, and the contact lines are pinned
to the disk edges. The perturbations are finite and axisymmetric. An analysis is based on the one-dimensional models previously
used in capillary jet theory and last several decades for study a liquid bridge dynamics. According to the scientific project
JEREMI (Japanese and European Research Experiment on Marangoni Instabilities), the first stage of the space experiment on
ISS will involve an isothermal liquid bridge with a gas blowing parallel to the axial direction of the bridge. The geometry
corresponds to a cylindrical volume liquid bridge coaxially placed into an outer cylinder with solid walls. The gas enters
the annular duct bounded by the outer cylinder and the internal system consisting of supporting vertical rods and the liquid
bridge. Considering that the bridge is small (the rod’s radii are 3 mm) and the gas velocity is typically (0.25 ÷ 0.37) m/s,
the perturbations cannot be considered small. Thus, one may assume that the amplitude of the liquid bridge perturbations is
sufficiently large that departures from linearity must be considered. 相似文献
9.
10.
Valentina M. Shevtsova D. E. Melnikov J. C. Legros 《Microgravity science and technology》2003,14(2):33-40
The effects of residual accelerations have been studied by using three-dimensional modeling of the flow in a rectangular cell
filled with a liquid, Pr=20, the walls of which were kept at different temperatures. The system was subjected to an acceleration
field, which can be decomposed into two parts: a steady component and another one which varies slowly with time, the frequency
is about f0≈10−3 Hz. The convective heat transport and flow characteristics are discussed for different parameters of g-jitter. The high and
low frequency modulation of a sinusoidal g-jitter is discussed. To capture many of the essential characteristics of buoyancy-induced
convection a new approach is suggested, which was developed based on the observation of the trajectories of tracer particles.
On the one hand, it is a typical way to record the flow in experiments. On the other hand, creating database of different
types of trajectories gives the possibility to solve the inverse problem. The shape of the trajectory depends on the g-jitter
parameters. It is shown that for slow convective motions the tracer particles perform loops along trajectory due to g-jitter
with low frequencies, and the additional high frequencies only cause trembling of the shape of these loops. Taking the experimentally
recorded trajectories of tracer particles and comparing with those in the database, one can draw a conclusion about the amplitude
and direction of the resulting gravity vector during the experiment. 相似文献