地球变暖,一个对钢铁工业的挑战

全球变暖给钢铁工业带来了巨大的挑战,挑战涉及使用碳的多少和能量利用率.低强度生产可以短期内达到减轻排放,使处于京都协议要求的水平.从中期看,更多地使用废钢也有助于减轻排放.但是为了实现更多地减少温室气体GHG的排放,也即等于实现京都协议之后的排放目标,钢铁工业必须设想有一个新的生产面貌,这形成了未来时期对它的最大挑战.碳的收集和吸收,碳使用中的代用剂,工艺流程中绿色来源的电和氢的应用,这些在未来10年中是必须要发展的,希望通过广泛地国际合作加以实现.     

The nuclear fuel cycle

In the first half of the 21st century, a redistribution of the energy data should occur, where nuclear will play a more important role, particularly as coal will become more and more costly to extract.On a worldwide basis, the unability of oil to be replaced in some areas like transportation, and the difficulty of developing countries to find substitutes for this energy source, could also lead developed countries to keep the energy resources for a better utilization, and give the countries which have no access to other resources, a possibility to develop.Thus, France has extensively enhanced nuclear energy for its electricity production, and, consequently, makes the necessary efforts for the knowledge of the whole fuel cycle.     

Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor of pristinamycin I

Dextran has been used as a carrier molecule for the synthesis of monofunctional peptide-dextran conjugates. The immunodetection of such carrier immobilized peptides on ELISA plates was compared to that of peptides adsorbed directly to immunoplates. The main features observed with peptide-dextran conjugates were as follows: only small amounts of peptide (1-2 mg) were necessary for coupling via alpha- or epsilon-amino groups to NaIO4-activated dextran (4 mg); the coupling yield was up to 68%; an amino acid analysis of the conjugate enabled the amount of carrier immobilized peptide to be calculated; an estimated 15-17 peptides were bound per dextran molecule (MW 73,500); using a carbohydrate as carrier reduces the possibility of non-specific interactions because no hydrophobic or ionic sites and no protein-like epitopes exist on the carrier apart from the peptide ligand. It can be assumed that some peptide ligands provide the forces for an interaction with the plate surface whereas other remain free for the interaction with the antibody. Thus, the detection with monoclonal anti-peptide antibodies allowed peptide-dextran conjugates to be used at coating concentrations of 1-3 nM peptide, corresponding to 0.6-2.6 ng peptide-dextran per well. In contrast, concentrations of 150-500 nM were required for coating with peptides. The applicability of monofunctional peptide-dextran conjugates was demonstrated by investigating the titer and specificity of a polyclonal anti-peptide serum developed against human gastrointestinal glutathione peroxidase. The introduction of biotin as a second ligand of the dextran conjugate permitted its capture on streptavidin coated plates. This synthesis of bifunctional peptide-biotin-dextran conjugates opens up additional possibilities for applications.     

Prebiotic synthesis of sequential peptides on the Hadean beach by a molecular engine working with nitrogen oxides as energy sources

Addressing the still open question of the prebiotic origin of sequential macromolecules (peptides, nucleic acids) on the primitive Earth, we describe a molecular engine (the primary pump), which works at ambient temperature and continuously generates, elongates and complexifies sequential peptides. This new scenario is based on a cyclic reaction sequence, whose keystep is the activation of amino acids into their N‐carboxyanhydrides (NCA) through nitrosation by NOx. This process could have taken place on tidal beaches; it requires a buffered ocean, emerged land and a nitrosating atmosphere. With the help of geochemical studies and computer simulations of atmosphere photochemistry, we show that the primitive Earth during the Hadean may have satisfied all these requirements. © 2001 Society of Chemical Industry.     

Stability, in-Vitro and in-Vivo Release Studies from Metronidazole Ointments

The influence of ointment formulation on the stability, the in-vitro release and the in-vivo absorption through the skin of rabbits was investigated. The choice of the selected ointments has no influence on the drug stability with the exception of an acidified emulsion base. A good correlation between in-vitro release and in-vivo absorption was found revealing that metronidazole was quickly released and effectively absorbed from a polyethylene glycol base.     

Marking student programs using graph similarity

We present a novel approach to the automated marking of student programming assignments. Our technique quantifies the structural similarity between unmarked student submissions and marked solutions, and is the basis by which we assign marks. This is accomplished through an efficient novel graph similarity measure (AssignSim). Our experiments show good correlation of assigned marks with that of a human marker.     

Optimization of quality and operational costs through improved scheduling of harvest operations

The agriculture sector still lacks the tools and models to enhance the utilization of different resources. This paper addresses the vineyard harvesting problem in developing countries, with the objective of optimizing the wine quality and minimizing the operational costs. Heuristics were introduced to better assign the harvesting days to the different grape blocks that exist in the vineyard's field. The quality of the grapes was a key target as it can transform production from a pinnacle wine to a bulk one. We solved several numerical examples for verification and demonstrative purposes and found that our proposed approach finds solutions that significantly reduce the harvesting costs in the vineyard and considerably outperform Branch and Bound algorithm especially for large problems.     

Generating systems from multiple sketched models

Diagrams are often used to model complex systems: in many cases several different types of diagrams are used to model different aspects of the system. These diagrams, perhaps from multiple stakeholders of different specialties, must be combined to achieve a full abstract representation of the system. Many CAD tools offer multi-diagram integration; however, sketch-based diagramming tools are yet to tackle this difficult integration problem. We extend the diagram sketching tool InkKit to combine software engineering sketches of different types. Our extensions support software design processes by providing a sketch-based approach that allows the iterative creation of multiple outputs interacting with one another from the inter-linked models. We demonstrate that InkKit can generate a functional system consisting of a user interface with processes to submit and retrieve data from a database from sketched user interfaces designs and sketched entity relationship diagrams.     

Airflow in a slot-ventilated enclosure partially filled with porous boxes: Part I - Measurements and simulations in the clear region

A reduced-scale model and CFD predictions were used to investigate experimentally and numerically the airflow patterns within a ceiling slot-ventilated enclosure partially loaded with vented boxes filled by spherical objects. The experiments were carried out using laser Doppler velocimetry. Airflows around and inside porous boxes were predicted taking into account their aerodynamic interactions. This work is divided into two parts. This paper presents part I and concerns the air velocity characteristics within the jet above the boxes, while Part II deals with the air velocity characteristics inside the boxes. The results highlight the confinement effect due to the enclosure and the influence of load porosity on jet penetration, its development and hence the heterogeneity of ventilation within the enclosure. The numerical predictions obtained with the computational fluid dynamics Fluent package using the RSM turbulence model show reasonable agreement with experimental data. Predicted velocity profiles were generally within an error of 3-30% of the measured velocities.