Digital advertising around paid spaces,E-advertising industry’s revenue engine: A review and research agenda

We develop and describe a framework for research in a particular segment of digital advertising. Internet Advertising Paid Slots and Spaces (IAPS) is a neologism and work almost like a stock exchange for buying and selling advertising in various formats on designated spaces around web and make a significant contribution to Internet advertising revenues. These paid spaces were found to encompass diverse areas of Internet advertising that include search engine marketing, social media advertising and display advertising. Given the complexity of the modern digital advertising eco system, this literature review seeks to provide clarity, up-to-date knowledge and ongoing insights into Internet advertising channels, for managers making investment decisions in this context.     

基于K个最近邻点的遗传程序的数字调制样式自动分类

在许多不同的民用和军用领域,调制样式自动分类都是一个非常有趣的问题。本文提出了一种基于K个最近邻点(K-Nearest Neighbor,KNN)的遗传程序(Genetic Programming,GP)算法。该算法采用了基于K个最近邻点的遗传程序,用来识别BPSK、QPSK、16QAM和64QAM调制信号。该算法用高阶累积量作为输入特征,并使用一种分两个阶段的分类方法来改善分类精度。计算机仿真将所提出算法与已有的算法进行了比较,从而证明了该算法的优异性能。     

Analysis of the decoupled uplink downlink technique for varying path loss exponent in multi-tier HetNet

In this paper, the impact of varying path loss exponent (PLE) on user association probability, decoupled uplink coverage probability as well as decoupled uplink average spectral efficiency in downlink uplink decoupled (DUDe) multi-tier heterogeneous networks, is investigated. We investigate the effect of the difference in path loss exponents in both macro and small cell environments over uplink network performance. It is assumed that the mobile user connected to the macro base station experience different path loss exponent as compared to when connected to small base station. It is observed that the difference of path loss exponents in both cases has significant effect on the user association probability, decoupled uplink coverage probability as well as decoupled uplink average spectral efficiency. Moreover, in order to further support key findings and make sound comparison between coupled and DUDe performance in varying PLE environment, generalized analytical expressions for coupled association probabilities, along with coupled uplink coverage probability and coupled uplink average spectral efficiency have been derived. The analytical results evaluated in this paper are compared with the computer simulation and found in good agreement. Our analysis shows that decoupling technique performs suboptimal for cases where the environments around macro and small base stations are different with respect to each other. The work explained in this paper highlights the limitation of applying DUDe technique in realistic conditions where the PLEs of cellular tiers are not exactly equal to one another.

     

Edge-Node-Aware Adaptive Data Processing Framework for Smart Grid

Wireless Personal Communications - Smart grid is an autonomous power generation and production system, that includes various energy management sub-systems such as energy efficient resources, smart...     

A Robust Zero-Watermarking Based on SIFT-DCT for Medical Images in the Encrypted Domain

Remote medical diagnosis can be realized by using the Internet, but when transmitting medical images of patients through the Internet, personal information of patients may be leaked. Aim at the security of medical information system and the protection of medical images, a novel robust zero-watermarking based on SIFT-DCT (Scale Invariant Feature Transform-Discrete Cosine Transform) for medical images in the encrypted domain is proposed. Firstly, the original medical image is encrypted in transform domain based on Logistic chaotic sequence to enhance the concealment of original medical images. Then, the SIFT-DCT is used to extract the feature sequences of encrypted medical images. Next, zero-watermarking technology is used to ensure that the region of interest of medical images are not changed. Finally, the robust of the algorithm is evaluated by the correlation coefficient between the original watermark and the attacked watermark. A series of attack experiments are carried out on this method, and the results show that the algorithm is not only secure, but also robust to both traditional and geometric attacks, especially in clipping attacks.     

Silver nanoparticles: A novel antibacterial agent for control of Cronobacter sakazakii

Silver nanoparticles (AgNP) have been widely applied because of their broad spectrum of antimicrobial activities against bacteria, fungi, and viruses. However, little research has been done to evaluate their effects on Cronobacter sakazakii, an opportunistic pathogen usually infecting infants and having a high fatality rate. The aims of this work were to investigate the antibacterial property of novel, synthesized, positively charged silver nanoparticles against C. sakazakii and to discuss the potential antibacterial mechanisms involved. In this study, the spherical and face-centered cubic silver nanoparticles had a mean particle size of 31.2 nm and were synthesized by reducing Ag⁺ using citrate and dispersed by glycerol and polyvinylpyrrolidone (PVP) under alkaline conditions. Minimum inhibitory concentrations (MIC) and inhibition zone tests showed that the AgNP exhibited strong antibacterial activity against 4 tested C. sakazakii strains with mean MIC of 62.5 to 125 mg/L and average inhibition zone diameters of 13.8 to 16.3 mm. Silver nanoparticles caused cell membrane injury accompanied by adsorption of AgNP onto the cell surface, as shown by changes in cell morphology, cell membrane hyperpolarization, and accelerated leakage of intracellular reducing sugars and proteins outward from the cytoplasm. In addition, dysfunction of the respiratory chain was induced after treatment with AgNP, which was supported by a decrease in intracellular ATP and inhibition of related dehydrogenases. This research indicates that AgNP could be a novel and efficient antibacterial agent to control C. sakazakii contamination in environments producing powdered infant formulas from milk.     

In Vitro Angiogenesis Inhibition and Endothelial Cell Growth and Morphology

A co-culture assay with human umbilical vein endothelial cells (HUVECs) and normal human dermal fibroblasts (NHDFs) was used to study whether selected angiogenesis inhibitors were able to inhibit differentiation and network formation of HUVECs in vitro. The effect of the inhibitors was determined by the morphology and the calculated percentage area covered by HUVECs. Neutralizing VEGF with avastin and polyclonal goat anti-VEGF antibody and inhibiting VEGFR2 with sorafenib and vatalanib resulted in the formation of HUVEC clusters of variable sizes as a result of inhibited EC differentiation. Furthermore, numerous inhibitors of the VEGF signaling pathways were tested for their effect on the growth and differentiation of HUVECs. The effects of these inhibitors did not reveal a cluster morphology, either individually or when combined to block VEGFR2 downstream pathways. Only the addition of N-methyl-p-bromolevamisole revealed a similar morphology as when targeting VEGF and VEGFR2, meaning it may have an inhibitory influence directly on VEGFR signaling. Additionally, several nuclear receptor ligands and miscellaneous compounds that might affect EC growth and differentiation were tested, but only dexamethasone gave rise to cluster formation similarly to VEGF-neutralizing compounds. These results point to a link between angiogenesis, HUVEC differentiation and glucocorticoid receptor activation.     

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate (MTX) delivery. The nanoparticles (NPs) were prepared by Abelmoschus esculentus mucilage (AEM) and chitosan (CS) by the modified coacervation method, followed by ultra-sonification. The NPs showed much better pharmaceutical properties with a spherical shape and smooth surface of 213.4–254.2 nm with PDI ranging between 0.279–0.485 size with entrapment efficiency varying from 42.08 ± 1.2 to 72.23 ± 2.0. The results revealed NPs to possess positive zeta potential and a low polydispersity index (PDI). The in-vitro drug release showed a sustained release of the drug up to 32 h with pH-dependence. Blank AEM -CS NPs showed no in-vivo toxicity for a time duration of 14 days, accompanied by high cytotoxic effects of optimized MTX loaded NPs against MCF-7 and MD-MBA231 cells by MTT assay. In conclusion, the findings advocated the therapeutic potential of AEM/CS NPs as an efficacious tool, offering a new perspective for pH-responsive routing of anticancer drugs with tumor cells as a target.