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Contamination of enteral diets may play an essential role in formula tolerance and safety for patients. Contaminated enteral formula commonly support microbiological growth. Commercially sterile liquid formulas received from the manufacturer are required by the Food & Drug Administration (FDA) to be shelf-stable and free from enteric pathogens. This study examined the use of large volume, closed system containers in a typical nursing home. Large volume (1500 mL) containers with unique pierceable caps and piercing spikes were studied to determine their ability to reduce the incidence of microbiological contamination due to their design and ability to decrease handling requirements. This study took place in a room of a typical nursing home. In this clinical setting, 211 containers and administration spike sets were evaluated following a 36-h hangtime. Contamination was virtually nondetectable. Nursing staff in a clinical facility can effectively utilize a large volume, prefilled, ready-to-use feeding system to achieve delivery of noncontaminated product for up to 36 h hangtime. 相似文献
3.
Ad hoc networks consist of wireless hosts that communicate with each other in the absence of a fixed infrastructure. Such networks cannot rely on centralized and organized network management. The clustering problem consists of partitioning network nodes into non-overlapping groups called clusters. Clusters give a hierarchical organization to the network that facilitates network management and that increases its scalability.In a weight-based clustering algorithm, the clusterheads are selected according to their weight (a node’s parameter). The higher the weight of a node, the more suitable this node is for the role of clusterhead. In ad hoc networks, the amount of bandwidth, memory space or battery power of a node could be used to determine weight values.A self-stabilizing algorithm, regardless of the initial system configuration, converges to legitimate configurations without external intervention. Due to this property, self-stabilizing algorithms tolerate transient faults and they are adaptive to any topology change.In this paper, we present a robust self-stabilizing weight-based clustering algorithm for ad hoc networks. The robustness property guarantees that, starting from an arbitrary configuration, after one asynchronous round, the network is partitioned into clusters. After that, the network stays partitioned during the convergence phase toward a legitimate configuration where the clusters verify the “ad hoc clustering properties”. 相似文献
4.
Mocker A Bugiel S Auer S Baust G Colette A Drake K Fiege K Grün E Heckmann F Helfert S Hillier J Kempf S Matt G Mellert T Munsat T Otto K Postberg F Röser HP Shu A Sternovsky Z Srama R 《The Review of scientific instruments》2011,82(9):095111
Investigating the dynamical and physical properties of cosmic dust can reveal a great deal of information about both the dust and its many sources. Over recent years, several spacecraft (e.g., Cassini, Stardust, Galileo, and Ulysses) have successfully characterised interstellar, interplanetary, and circumplanetary dust using a variety of techniques, including in situ analyses and sample return. Charge, mass, and velocity measurements of the dust are performed either directly (induced charge signals) or indirectly (mass and velocity from impact ionisation signals or crater morphology) and constrain the dynamical parameters of the dust grains. Dust compositional information may be obtained via either time-of-flight mass spectrometry of the impact plasma or direct sample return. The accurate and reliable interpretation of collected spacecraft data requires a comprehensive programme of terrestrial instrument calibration. This process involves accelerating suitable solar system analogue dust particles to hypervelocity speeds in the laboratory, an activity performed at the Max Planck Institut fu?r Kernphysik in Heidelberg, Germany. Here, a 2 MV Van de Graaff accelerator electrostatically accelerates charged micron and submicron-sized dust particles to speeds up to 80 km s(-1). Recent advances in dust production and processing have allowed solar system analogue dust particles (silicates and other minerals) to be coated with a thin conductive shell, enabling them to be charged and accelerated. Refinements and upgrades to the beam line instrumentation and electronics now allow for the reliable selection of particles at velocities of 1-80 km s(-1) and with diameters of between 0.05 μm and 5 μm. This ability to select particles for subsequent impact studies based on their charges, masses, or velocities is provided by a particle selection unit (PSU). The PSU contains a field programmable gate array, capable of monitoring in real time the particles' speeds and charges, and is controlled remotely by a custom, platform independent, software package. The new control instrumentation and electronics, together with the wide range of accelerable particle types, allow the controlled investigation of hypervelocity impact phenomena across a hitherto unobtainable range of impact parameters. 相似文献
5.
Geoffrey Haddou Jany Dandurand Eric Dantras Huynh Maiduc Hoang Thai Nguyen Vu Giang Tran Huu Trung Philippe Ponteins Colette Lacabanne 《应用聚合物科学杂志》2019,136(23):47623
This study is devoted to the analysis of the properties of continuous bamboo fiber (BF)-reinforced polyamide 11 (PA 11) composites. The SEM observations highlighted continuity between BFs and the polymeric matrix showing a high density of hydrogen bonds. The comparative calorimetric study of the matrix and its composites showed that the crystallinity of PA 11 was not modified by the presence of bamboo fibers. The physical aging observed in PA 11 is no more observed in composites due to physical interactions between PA 11 and BFs. The mechanical properties were investigated by tensile strength and dynamic mechanical analysis. The introduction of BFs enhanced Young's modulus of the matrix by a factor of 10. The presence of BFs also improved the storage shear modulus G′ over the whole temperature range. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47623. 相似文献
6.
Influence of new thermoplastic sizing agents on the mechanical behavior of poly(ether ketone ketone)/carbon fiber composites
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Isabelle Giraud Sophie Franceschi Emile Perez Colette Lacabanne Eric Dantras 《应用聚合物科学杂志》2015,132(38)
In this study, unidirectional poly(ether ether ketone)/carbon fiber (CF) composite sheets were elaborated with unsized, epoxy‐sized, and thermoplastic‐sized CFs by hot‐press molding. The thermoplastic sizings that we used were poly(ether imide) (PEI) and poly(ether ketone ketone) oligomer aqueous dispersions. Scanning electron microscopy observation of the composites freeze fractures showed that unlike unsized or epoxy‐sized CFs, the thermoplastic sizings improved the interaction between the fibers and the matrix. A comparative study of the mechanical relaxations by dynamic mechanical analysis was carried out on the different composites before and after immersion in kerosene. At low temperature, the PEI sizing had a significant influence on the β relaxation, particularly after kerosene immersion. The thermoplastic sizings did not modify the glass‐transition temperature but improved the kerosene resistance on the composites. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42550. 相似文献
7.
Dr. Marie Monestier Peggy Charbonnier Dr. Christelle Gateau Dr. Martine Cuillel Faustine Robert Colette Lebrun Dr. Elisabeth Mintz Prof. Olivier Renaudet Dr. Pascale Delangle 《Chembiochem : a European journal of chemical biology》2016,17(7):590-594
Liver cells are an essential target for drug delivery in many diseases. The hepatocytes express the asialoglycoprotein receptor (ASGPR), which promotes specific uptake by means of N‐acetylgalactosamine (GalNAc) recognition. In this work, we designed two different chemical architectures to treat Wilson's disease by intracellular copper chelation. Two glycoconjugates functionalized with three or four GalNAc units each were shown to enter hepatic cells and chelate copper. Here, we studied two series of compounds derived from these glycoconjugates to find key parameters for the targeting of human hepatocytes. Efficient cellular uptake was demonstrated by flow cytometry using HepG2 human heptic cells that express the human oligomeric ASGPR. Dissociation constants in the nanomolar range showed efficient multivalent interactions with the receptor. Both architectures were therefore concluded to be able to compete with endogeneous asialoglycoproteins and serve as good vehicles for drug delivery in hepatocytes. 相似文献
8.
Kassoum Barry Gisèle Laure Lecomte-Nana Mohamed Seynou Michael Faucher Philippe Blanchart Claire Peyratout 《International Journal of Applied Ceramic Technology》2022,19(6):3084-3098
Silicate ceramics were shaped using tape casting (TC) and freeze tape casting (FTC) processes from three clays labeled HCR, KORS, and KCR. These clays exhibited mass content of 77% halloysite–10 Å, 29% kaolinite, and 98% kaolinite minerals, respectively. After casting the slurries, the dried tapes were sintered at 1200°C. The microstructure changes were characterized before and after sintering using scanning electron microscopy. The apparent porosity of TC samples was lower (36–47 vol.%) compared to values obtained with FTC samples (67–79 vol.%). The latter samples exhibited a highly textured porosity, with micron-sized pores aligned perpendicular to the tape surfaces. Upon sintering, the porosity of TC samples tended to decrease conversely to the case of FTC samples. Such behavior seemed related to the simultaneous effect of organic additives and ice templating. Consequently, the FTC samples showed a relatively low mechanical strength of 3–7 MPa and thermal conductivity of .14– .22 W m−1 K−1. After sintering, the mullite crystallization contributed to strengthen the bulk materials, helping to compensate for the detrimental effect of porosity on the stress to rupture and on thermal conductivity values. 相似文献
9.
The controlled synthesis of narrowly distributed low molecular weight polymers with functionalization possibilities is of great industrial interests. Although living polymerization allows for control over polymer architecture, the production of low molecular weight polymers with low polydispersities via living polymerization systems is challenged by the use of large amounts of catalysts and broadening in molecular weight distribution. This review addresses the synthesis of narrowly distributed, functional, low molecular weight polyethylene and polyethylene mimics. The review is structured for quick identification of relevant systems for the production of specific polymer architectures with specific cost, efficiency, and safety concerns. 相似文献
10.
A variety of human land uses involve the release of toxins into the environment. Wildlife live alongside humans across this array of land uses and thus, are exposed to varying chemical milieus. Kidneys are the principle excretory organs for vertebrates and excessive or chronic exposure to exogenous toxins can lead to renal pathology and renal failure. Although studies have linked chemical exposure to specific renal diseases across diverse taxa, none compare renal lesions occurring in wildlife living in different types of human-modified landscapes. We identify lesions characteristic of renal stress, including toxin exposure, in 82 giant toad (Bufo marinus) males living in habitats ranging from suburban to agricultural. In a previous study [McCoy K.A., Bortnick L.J., Campbell C.M., Hamlin H.J., Guillette L.J., Jr., St. Mary C.M. Agriculture Alters Gonadal Form and Function in Bufo marinus. Environ Health Persp; in press.], these individuals were examined for gonadal abnormalities, which were significantly and positively associated with percentage of agriculture at the collection site. Thus, we hypothesized the same association for renal abnormalities. We scored gross anatomical abnormalities and used light microscopy to identify tubular and interstitial lesions that have been associated with toxicant exposure in other organisms, including humans. Renal lesions indicative of tubular disease were observed at one suburban and two agricultural sites, whereas interstitial lesions were most severe at one agricultural site. Although there was no relationship between frequency of renal disease and proportion of agriculture in the collection vicinity, the renal lesions we identify are consistent with toxin exposure and are similar to those found in human drug abusers and patients suffering medication-induced nephropathy. This is the first study to describe renal lesions in a wild amphibian species and investigate the distribution of renal lesions across human altered landscapes. Indentifying the chemicals inducing renal lesions across these landscapes, their toxicological mechanisms, and their implications on wildlife health will help us devise strategies to mitigate the impacts of toxins on humans and animals living in human-modified environments. 相似文献