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排序方式: 共有710条查询结果,搜索用时 11 毫秒
1.
Gert van der Horn Johan H. Huijsing 《Analog Integrated Circuits and Signal Processing》1997,14(3):207-222
In many applications electronic sensors are used toimprove performance and reliability of measurement systems. Suchsensors should provide a correct transfer from the physical signalto be measured to the electrical output signal. One importantstep to achieve this, is to calibrate each sensor by applyingdifferent reference input signals and adjusting the sensor transferaccordingly. Besides expensive reference equipment the calibrationprocess takes much time and attention per individual sensor,which means a considerable increase in sensor production costs.By including at the sensor or sensor interface chip a programmablecalibration facility the calibration of such smart sensors caneasily be automated and can be executed for a batch of sensorsat a time, thus minimizing the calibration time and costs. Thispaper presents a calibration method and options for integrationin the smart sensor concept, in hardware as well as in software.An advantage of the proposed method is that it does not needa large matrix of calibration data, which needs to be storedin a look-up table or converted into a correction formula, butinstead it uses a step-by-step approach to correct the sensortransfer at each calibration measurement until the error is sufficientlysmall. 相似文献
2.
3.
Lei Wang Charlotte E. Pelgrim Daniël H. Swart Guido Krenning Adrianus C. van der Graaf Aletta D. Kraneveld Thea Leusink-Muis Ingrid van Ark Johan Garssen Gert Folkerts Saskia Braber 《International journal of molecular sciences》2021,22(9)
Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether the novel compound SUL-151 with mitoprotective properties can be used as a prophylactic and therapeutic treatment in a murine CS-induced inflammation model. SUL-151 (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation in this prophylactic and therapeutic treatment setting. The number of immune cells was determined in the bronchoalveolar lavage fluid (BALF). Oxidative stress response, mitochondrial adenosine triphosphate (ATP) production, and mitophagy-related proteins were measured in lung homogenates. SUL-151 significantly decreased more than 70% and 50% of CS-induced neutrophils in BALF after prophylactic and therapeutic administration, while budesonide showed no significant reduction in neutrophils. Moreover, SUL-151 prevented the CS-induced decrease in ATP and mitochondrial mtDNA and an increase in putative protein kinase 1 expression in the lung homogenates. The concentration of SUL-151 was significantly correlated with malondialdehyde level and radical scavenging activity in the lungs. SUL-151 inhibited the increased pulmonary inflammation and mitochondrial dysfunction in this CS-induced inflammation model, which implied that SUL-151 might be a promising candidate for COPD treatment. 相似文献
4.
Free and esterifed cholesterol were determined in parotid fluid collected from 19 individuals by encapsulation of Stenson's
duct in the oral 16.7±7.1 (SD) μg/100 ml and cholesterol esters averaged 13.2±8.0 (SD) μg/100 ml. Two assays are described
for the measurement of cholesterol in parotid saliva. Lipophilic material was extracted with ether-ethanol (3∶1). In assay
1, the solid residue of the extract was separated into its components by thin layer chromatography. Substances on the chromatogram
were made to fluoresce and the spots were photographed. Cholesterol was determined by densitometry of its black image on film.
In assay 2, the ether-ethanol residue was subjected to quantitative gas chromatography. Both methods yield similar data. 相似文献
5.
Gert Roebben Omer Van der Biest Diletta Sciti Alida Bellosi Corneliu Sarbu Tom Lauwagie 《Journal of the American Ceramic Society》2005,88(8):2152-2158
Detailed stiffness and internal friction ( Q −1 ) versus temperature curves were obtained for liquid-phase-sintered silicon carbides using advanced resonant beam analysis up to 1400°C. As-sintered materials display a stable Q −1 -peak near 1100°C, superimposed on an increasing background. The change of stiffness associated with the damping peak is quantitatively related to the amount of matter in pockets of the amorphous intergranular phase in which the refractory SiC matrix grains are embedded. The successful removal of the amorphous pockets by annealing at 1900°C is deduced from the disappearance of the damping peak and confirmed with transmission electron microscopy. 相似文献
6.
Elastomer materials are used in a wide application range and subjected to different loading from which failure of the material results. Because this failure is caused by initiation and propagation of cracks, the application of fracture mechanics methods for the assessment of the material is obvious. A short summary of the methods of technical fracture mechanics including possibilities of determination of crack resistance curves is given. Vulcanizates on the basis of SBR 1500 with various sulfur and carbon black contents were investigated. For describing the crack initiation and crack propagation behavior, several fracture mechanics examination methods were applied. Tear‐analyzer results were used to assess the crack propagation behavior under fatigue‐like loading conditions. Furthermore, for the characterization of the crack resistance of the materials under impact‐like loading conditions, instrumented tensile‐impact tests were performed. To obtain information about the initiation and propagation of a stable crack, quasi‐static fracture mechanics tests were applied. The results of the several tests are discussed in dependence on sulfur and carbon black contents. We found a non‐monotonous behavior of the toughness as a function of carbon black loading. An explanation is given in connection with a percolation‐like transition in filler morphology on larger length scales.
7.
Eijsink Vincent G.H.; Vriend Gerrit; van den Burg Bertus; Venema Gerard; Stulp Ben K. 《Protein engineering, design & selection : PEDS》1990,4(1):99-104
The role of the C-terminal Leu300 in maintaining thermal stabilityof the neutral protease of Bacillus subtilis was investigated.From model building studies based on the three dimensional structureof thermolysin, the neutral protease of B.thermoproteolyticus,it was conduded that this residue is located in a hydrophobicpocket composed of residues located in the C-terminal and themiddle domain. To test the hypothesis that Leu300, by contributingto a stabilizing interaction between these domains, is importantfor enzyme stability, several neutral protease mutants wereconstructed and characterized. The thermostability of the enzymewas lowered by deleting Leu300 or by replacing this residueby a smaller (Ala), a polar (Asn) or a sterically unfavourable(He) amino acid. Thermostabiity was increased upon replacingLeu300 by Phe. These results are in agreement with model-buildingstudies. The effects on thermostability observed after mutatingthe corresponding Val318 in the thermostable neutral proteaseof B.stearothermophilus were less pronounced. 相似文献
8.
B Gert 《Canadian Metallurgical Quarterly》1996,63(2):72-76
I take advantage of a point made by H. J. Gert, in "Rights and Rights Violators: A New Approach to the Nature of Rights" (The Journal of Philosophy 1990; 87 (12): 688-694) to provide the following definition of violence. "Violence is an intentional or knowing attempt by a moral agent to directly cause harm, i.e., death, pain, disability, loss of freedom or pleasure, to someone who is protected by morality without the consent of that person." I show how this definition applies to violence in hospitals and discuss some of the ethical problems created by violent patients. 相似文献
9.
Fast simulation (e.g., real-time) of flexible multibody systems is typically restricted by the presence of both differential
and algebraic equations in the model equations, and the number of degrees of freedom required to accurately model flexibility.
Model reduction techniques can alleviate the problem, although the classically used body-level model reduction and general-purpose
system-level techniques do not eliminate the algebraic equations and do not necessarily result in optimal dimension reduction.
In this research, Global Modal Parametrization, a model reduction technique for flexible multibody systems is further developed
to speed up simulation of flexible multibody systems. The reduction of the model is achieved by projection on a curvilinear
subspace instead of the classically used fixed vector space, requiring significantly less degrees of freedom to represent
the system dynamics with the same level of accuracy. The numerical experiment in this paper illustrates previously unexposed
sources of approximation error: (1) the rigid body motion is computed in a forward dynamical analysis resulting in a small
divergence of the rigid body motion, and (2) the errors resulting from the transformation from the modal degrees of freedom
of the reduced model back to the original degrees of freedom. The effect of the configuration space discretization coarseness
on the different approximation error sources is investigated. The trade-offs to be defined by the user to control these approximation
errors are explained. 相似文献
10.
In this paper we give an overview over a series of experiments to visualize and measure flow fields in the human vascular
system with respect to their diagnostic capabilities. The experiments utilize a selection of GPU-based sparse and dense flow
visualization algorithms to show the diagnostic opportunities for volumetric cardiovascular phase contrast magnetic resonance
imaging data sets. Besides classical hardware accelerated particle and line-based approaches, an extensible tublet-based visualization,
a four-dimensional volumetric line integral convolution and a new two-dimensional cutting plane tool for three-dimensional
velocity data sets have been implemented. To evaluate the results, several hearts of human subjects have been investigated
and a flow phantom was built to artificially simulate distinctive flow features. Our results demonstrate that we are able
to provide an interactive tool for cardiovascular diagnostics with complementary hardware accelerated visualizations.
Electronic Supplementary Material The online version of this article () contains supplementary material, which is available to authorized users.
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Dieter SchmalstiegEmail: |