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排序方式: 共有1397条查询结果,搜索用时 15 毫秒
1.
F F?ndrich AM Waaga J Schr?der E Schweizer A Schmid S Jacob HH Wacker P Schroeder 《Canadian Metallurgical Quarterly》1995,27(2):1553-1554
2.
PL Pirie BL Rooney TF Pechacek HA Lando LA Schmid 《Canadian Metallurgical Quarterly》1997,22(1):131-137
Exposure to foreign particles sometimes causes inflammatory reactions through production of cytokines and chemoattractants by phagocytic cells. In this study, we focused on macrophage migration inhibitory factor (MIF) to evaluate its pathophysiological role in the phagocytic process. Immunohistochemical analysis of human pseudosynovial tissues retrieved at revision of total hip arthroplasty showed that infiltrating mononuclear and multinuclear cells were positively stained by both an anti-CD68 antibody and anti-human MIF antibody. For in vitro study, MIF was released from murine macrophage-like cells (RAW 264.7) in response to phagocytosis of fluorescent-latex beads in a particle dose-dependent manner. Northern blot analysis showed marked elevation of the MIF mRNA level in the phagocytic macrophage-like cells. Moreover, pretreatment of RAW 264.7 cells with rat recombinant MIF increased the extent of phagocytosis by 1.6-fold compared with the control. Taken together, these results suggest that MIF plays an important role by activating macrophages in autocrine and paracrine fashion to phagocytose foreign particles. 相似文献
3.
The dynamic interaction, through the underlying or surrounding soil, between three-dimensional structures has been investigated, by coupling finite and boundary elements. The structures are discretized by finite elements, and the infinite soil is represented by boundary elements. A harmonic force is applied on both mass-lumped structures and mass-distributed structures. On the basis of our numerical studies, we further indicate the effects of distance, direction of alignment between two foundations, bedrock, natural frequency of the system and the location of load on the dynamic responses of structure-soil-structure interaction systems. 相似文献
4.
5.
M Burkhardt T Kupper S Hean R Haag P Schmid M Kohler M Boller 《Water science and technology》2007,56(12):63-67
There is increasing concern about diffuse pollution of aquatic systems by biocides used in urban areas. We investigated sources and pathways of biocides significant for the pollution of storm water runoff. Main sources seem to be building envelopes, i.e. facades (paints, plasters) and roof sealing membranes. First results from a defined urban catchment drained by a separated sewer system without any agricultural activities reveal a substantial occurrence. Even after the first flush, concentrations of terbutryn, carbendazim, mecoprop as well as Irgarol 1051 and its metabolite exceeded the Swiss water quality standard of 0.1 microg/L. In laboratory experiments, leaching of mecoprop used as a root protection agent in bitumen sheets for roof waterproofing was determined. The concentrations differed in 16 different sheets two orders of magnitude, depending on the product composition. Using optimized products, it is expected to be the most efficient and sustainable way to reduce the environmental impact. To understand transport dynamics and environmental risk, further storm water events will be analyzed. Based on the ongoing project URBIC, first measures will be proposed to limit the release to surface and ground water. 相似文献
6.
MS Oitzl ER de Kloet M Jo?ls W Schmid TJ Cole 《Canadian Metallurgical Quarterly》1997,9(11):2284-2296
Previous studies in rats using the Morris water maze suggested that the processing of spatial information is modulated by corticosteroid hormones through mineralocorticoid and glucocorticoid receptors in the hippocampus. Mineralocorticoid receptors appear to be involved in the modulation of explorative behaviour, while additional activation of glucocorticoid receptors facilitates the storage of information. In the present study we used the water maze task to examine spatial learning and memory in mice homozygous and heterozygous for a targeted disruption of the glucocorticoid receptor gene. Compared with wild-type controls, homozygous and heterozygous mice were impaired in the processing of spatial but not visual information. Homozygous mutants performed variably during training, without specific platform-directed search strategies. The spatial learning disability was partly compensated for by increased motor activity. The deficits were indicative of a dysfunction of glucocorticoid receptors as well as of mineralocorticoid receptors. Although the heterozygous mice performed similarly to wild-type mice with respect to latency to find the platform, their strategy was more similar to that of the homozygous mice. Glucocorticoid receptor-related long-term spatial memory was impaired. The increased behavioural reactivity of the heterozygous mice in the open field points to a more prominent mineralocorticoid receptor-mediated function. The findings indicate that (i) the glucocorticoid receptor is of critical importance for the control of spatial behavioural functions, and (ii) mineralocorticoid receptor-mediated effects on this behaviour require interaction with functional glucocorticoid receptors. Until the development of site-specific, inducible glucocorticoid receptor mutants, glucocorticoid receptor-knockout mice present the only animal model for the study of corticosteroid-mediated effects in the complete absence of a functional receptor. 相似文献
7.
State-of-the-art Web applications include both navigational elements and business processes, but most Web application design methods treat business processes as just another kind of navigation. The authors' extensions to the object-oriented hypermedia design method (OOHDM) aim to remedy this situation. Rather than using navigation to emulate business processes, their new mechanisms allow developers to specify and implement processes explicitly by dealing with activity semantics and states. We describe proposed extensions to OOHDM and explore their use at an online retail store. 相似文献
8.
Forster Jean L.; Jeffery Robert W.; Schmid Thomas L.; Kramer F. Matthew 《Canadian Metallurgical Quarterly》1988,7(6):515
Evaluated the feasibility and effectiveness of a program for weight gain prevention (WGP) in normal adults. 219 Ss were randomized to either WGP treatment or no treatment for 12 mo. The treatment group received monthly newsletters relating to weight management, participated in a financial incentive system, and were offered an optional 4-session education course in the 6th mo of the program. Results demonstrate high interest in WGP among Ss who were not objectively overweight. Participation, as measured by return of postcards sent with each newsletter, was approximately 75%. Results after 1 yr show a net weight loss of 1.8 lb in the group receiving the program compared with controls. 82% of participants maintained or lost weight, compared with 56% of controls. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
A micromachined hot-film anemometer on a high-pressure stable substrate is demonstrated to be suitable for "on-board" measurements of various injection quantities, which are needed in modern direct injection systems for optimum performance of diesel, as well as gasoline, engines. To estimate the velocity profile in the injection nozzle during the injection pulse, two-dimensional finite element method calculations are performed. To consider the substrate effect on the performance of the thermal injection rate sensor, an IR imaging system is used to determine the heat loss via the robust glass ceramic substrate up to thin-film temperatures of 450 K in air. Using both the numerical and the experimental results, the temperature sensitivity and velocity sensitivity of hot-film anemometers, operated in the constant current mode in a fuel atmosphere, can be modeled analytically. Finally, an overview about the results of the latest injection rate measurements at fuel pressures up to 60 MPa and drive pulse lengths between 0.2-5 ms is given. Comparing these signals of the thermal thin-film sensor to injection volume measurements, performed with an injection amount indicator at a high-pressure hydraulic test bench, the mass flow measurements can be calibrated. One empiric parameter is necessary, which is the exponent of a power law dependence on the maximum sensor amplitude during injection. 相似文献
10.
Herve Charlery Author Vitae Adrijean Andriahantenaina Author Vitae Author Vitae 《Computers & Electrical Engineering》2007,33(4):299-309
This paper presents the physical design methodology of the VCI/SPIN wrappers. The challenge was the validation of the wrappers’ specification with Alliance CAD Tools.A wrapper is a standard gateway used by a subscriber to access an interconnect. Because there are as many wrappers as subscribers, it is relevant to have an estimation of the wrapper’s area, its frequency and then compare these results to the router’s.The interest to perform this study with academic tools is to show that commercial tools are not the unique way for experimentations. 相似文献