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1.
Goren Y Davrath LR Pinhas I Toledo E Akselrod S 《IEEE transactions on bio-medical engineering》2006,53(1):35-42
Heart rate variability (HRV) is a major noninvasive technique for evaluating the autonomic nervous system (ANS). Use of time-frequency approach to analyze HRV allows investigating the ANS behavior from the power integrals, as a function of time, in both steady-state and non steady-state. Power integrals are examined mainly in the low-frequency and the high-frequency bands. Traditionally, constant boundaries are chosen to determine the frequency bands of interest. However, these ranges are individual, and can be strongly affected by physiologic conditions (body position, breathing frequency). In order to determine the dynamic boundaries of the frequency bands more accurately, especially during autonomic challenges, we developed an algorithm for the detection of individual time-dependent spectral boundaries (ITSB). The ITSB was tested on recordings from a series of standard autonomic maneuvers with rest periods between them, and the response to stand was compared to the known physiological response. A major advantage of the ITSB is the ability to reliably define the mid-frequency range, which provides the potential to investigate the physiologic importance of this range. 相似文献
2.
Y Itzhak 《Canadian Metallurgical Quarterly》1996,35(8):1065-1073
Recent studies suggest the involvement of the N-methyl-D-aspartate (NMDA) type of glutamate receptors and nitric oxide synthase (NOS) in the process of increased sensitivity to the convulsive effect of cocaine (\"cocaine kindling\"). The present study was undertaken to analyze the various behavioral stages in the development of cocaine kindling and to investigate the effect of 7-nitroindazole (7-NI), a relatively selective inhibitor of the neuronal NOS isoform, on the induction and expression of sensitization to the convulsive effect of cocaine. Also, the effect of 7-NI on responses produced by acute systemic administration of cocaine or N-methyl-D,L-aspartate (NMDLA) was investigated. Cocaine kindling was assessed on a five-stage scale following the administration of a sub-convulsant dose of the drug (35 mg/kg/day; i.p.) to Swiss Webster mice for 10 days. Stage 5 seizures developed following the 9th day of cocaine administration. Pre-treatment with 7-NI (25 mg/kg/day; i.p.) 15 min before cocaine for 10 days completely prevented the appearance of stage 4 and 5 seizures, and it significantly attenuated stage 3 behavior in response to a challenge cocaine dose (35 mg/kg) given either 24 hr or 10 days after 7-NI/cocaine administration was stopped. A single injection of 7-NI (25 mg/kg; i.p.) completely prevented the expression of cocaine kindled seizures. Whereas 7-NI had no effect on the responses elicited by acute cocaine administration (60 mg/kg; i.p.), this agent partially attenuated the effects induced by systemic administration of the NMDA receptor agonist NMDLA (250 mg/kg; i.p.). The present study indicates that 7-NI attenuates both the induction and expression of sensitization to the convulsive effect of cocaine. The findings that 7-NI attenuated cocaine kindling and partially blocked the effects produced by activation of the NMDA receptor, but not the effects induced by acute cocaine administration, support the role of the NMDA receptor and brain NOS in the development of cocaine kindling rather than in the acute effects of the drug. 相似文献
3.
A model of a repetitive multiproject management is introduced that includes uncertainties in activity durations, and the corresponding quantities of resources needed. Following the convention, a project is viewed here as a network of related activities aimed at the accomplishment of a predetermined objective at a given deadline. A project has a starting point in time and a preplanned completion point and so does each activity within it. The structural and operational characteristics described here are drawn from organization and management theories and used to describe project organization. This is demonstrated by means of field data gathered from a sample of ‘bloodmobile projects’ - an organized effort for the collection of blood donations in support of medical needs. 相似文献
4.
A modular multi-layer sampler was developed and utilized for sampling undisturbed groundwater chemical profiles. Sampling at 3 cm depth intervals is based on the dialysis-cell method and has no depth limitations. The sampler may be used for water quality monitoring and research, both in existing or specially drilled screened wells 相似文献
5.
A low pressure r.f. plasma was applied to deposit SiC coatings onto Ti6A14V substrates. The coatings were deposited onto substrates at temperatures of 140–390°C from a gas mixture of tetramethylsilane (TMS), argon and hydrogen. Scanning electron microscopy, X-ray diffraction and transmission electron microscopy were employed to identify and to characterize the coatings obtained. It was found that the coatings were hexagonal α-SiC of type III. The coating thickness approximately follows a parabolic time law. A maximum rate of deposition was observed in the pressure range 5–6 mbar. The rate of deposition increases with concentration of TMS up to 0.05% and remains approximately constant up to 0.12% 相似文献
6.
Shirom Arie; Melamed Samuel; Rogowski Ori; Shapira Itzhak; Berliner Shlomo 《Canadian Metallurgical Quarterly》2009,14(4):349
The authors investigated the direct and interactive effects of the job demand– control–support (JDC-S) model’s components on subsequent changes in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides (TRI) separately for male and female employees. In contrast to all 14 past studies on these relationships, the authors used a longitudinal design. Study participants (N = 1,137, 66% men) were all apparently healthy employees who underwent a routine health check at 2 points in time (Time 1 and Time 2) about 22 months apart. In these analyses, the authors controlled for the Time 1 level of each criterion and for other confounders. Most of the direct and moderating effects found did not support the predictions of the JDC-S model; this finding is in agreement with the majority of past cross-sectional studies. The authors did not find any evidence supporting the existence of a reverse causation for either of the components of the JDC-S model. The authors suggest that serum lipids may not be a physiological mechanism mediating the effects of the JDC-S model on atherosclerotic diseases. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
Boron nitride (BN) coatings were deposited onto die steel and graphite substrates with a low pressure r.f. plasma. The coatings were deposited onto substrates at temperatures of 550–620 °C from a gas mixture of argon, NH3 and BCl3. X-ray diffraction and scanning electron microscopy were employed to identify and to characterize the coatings. The coatings are mostly amorphous; however, the existence of small amounts of hexagonal BN was identified. The influence on the growth rate of the deposition time and the pressure in the reactor is described. 相似文献
8.
9.
A new method of kernel density estimation with a varying adaptive window size is proposed. It is based on the so-called intersection of confidence intervals (ICI) rule. Several examples of the proposed method are given for different types of densities and the quality of the adaptive density estimate is assessed by means of numerical simulations. 相似文献
10.
Itzhak I. Maor Katharina Kruppa Adi Rozencweig Amir Sterzer Frank Steinbach Vadim Beilin Bernd Breidenstein Gennady E. Shter Meirav Mann-Lahav Armin Feldhoff Gideon S. Grader 《Advanced functional materials》2023,33(49):2304464
Calcium cobaltite Ca3Co4−xO9+δ (CCO) is a promising p-type thermoelectric (TE) material for high-temperature applications in air. The grains of the material exhibit strong anisotropic properties, making texturing and nanostructuring mostly favored to improve thermoelectric performance. On the one hand multitude of interfaces are needed within the bulk material to create reflecting surfaces that can lower the thermal conductivity. On the other hand, low residual porosity is needed to improve the contact between grains and raise the electrical conductivity. In this study, CCO fibers with 100% flat cross sections in a stacked, compact form are electrospun. Then the grains within the nanoribbons in the plane of the fibers are grown. Finally, the nanoribbons are electrospun into a textured ceramic that features simultaneously a high electrical conductivity of 177 S cm−1 and an immensely enhanced Seebeck coefficient of 200 µV K−1 at 1073 K are assembled. The power factor of 4.68 µW cm−1 K−2 at 1073 K in air surpasses all previous CCO TE performances of nanofiber ceramics by a factor of two. Given the relatively high power factor combined with low thermal conductivity, a relatively large figure-of-merit of 0.3 at 873 K in the air for the textured nanoribbon ceramic is obtained. 相似文献