Consequences and conjectures in preordered sets

In a preordered set, or preset, consequence operators in the sense of Tarski, defined on families of subsets, are introduced. From them, the corresponding sets of conjectures, hypotheses, speculations and refutations are considered, studying the relationships between these sets and those previously defined on ortholattices. All the concepts introduced are illustrated with three particular consequence operators, whose behavior is studied in detail. The results obtained are applied to the case of fuzzy sets endowed with the usual pointwise ordering.     

Establishing In-House Cutoffs of CSF Alzheimer’s Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort

Background: Clinical diagnosis of Alzheimer’s disease (AD) increasingly incorporates CSF biomarkers. However, due to the intrinsic variability of the immunodetection techniques used to measure these biomarkers, establishing in-house cutoffs defining the positivity/negativity of CSF biomarkers is recommended. However, the cutoffs currently published are usually reported by using cross-sectional datasets, not providing evidence about its intrinsic prognostic value when applied to real-world memory clinic cases. Methods: We quantified CSF Aβ1-42, Aβ1-40, t-Tau, and p181Tau with standard INNOTEST^® ELISA and Lumipulse G^® chemiluminescence enzyme immunoassay (CLEIA) performed on the automated Lumipulse G600II. Determination of cutoffs included patients clinically diagnosed with probable Alzheimer’s disease (AD, n = 37) and subjective cognitive decline subjects (SCD, n = 45), cognitively stable for 3 years and with no evidence of brain amyloidosis in 18F-Florbetaben-labeled positron emission tomography (FBB-PET). To compare both methods, a subset of samples for Aβ1-42 (n = 519), t-Tau (n = 399), p181Tau (n = 77), and Aβ1-40 (n = 44) was analyzed. Kappa agreement of single biomarkers and Aβ1-42/Aβ1-40 was evaluated in an independent group of mild cognitive impairment (MCI) and dementia patients (n = 68). Next, established cutoffs were applied to a large real-world cohort of MCI subjects with follow-up data available (n = 647). Results: Cutoff values of Aβ1-42 and t-Tau were higher for CLEIA than for ELISA and similar for p181Tau. Spearman coefficients ranged between 0.81 for Aβ1-40 and 0.96 for p181TAU. Passing–Bablok analysis showed a systematic and proportional difference for all biomarkers but only systematic for Aβ1-40. Bland–Altman analysis showed an average difference between methods in favor of CLEIA. Kappa agreement for single biomarkers was good but lower for the Aβ1-42/Aβ1-40 ratio. Using the calculated cutoffs, we were able to stratify MCI subjects into four AT(N) categories. Kaplan–Meier analyses of AT(N) categories demonstrated gradual and differential dementia conversion rates (p = 9.815⁻²⁷). Multivariate Cox proportional hazard models corroborated these findings, demonstrating that the proposed AT(N) classifier has prognostic value. AT(N) categories are only modestly influenced by other known factors associated with disease progression. Conclusions: We established CLEIA and ELISA internal cutoffs to discriminate AD patients from amyloid-negative SCD individuals. The results obtained by both methods are not interchangeable but show good agreement. CLEIA is a good and faster alternative to manual ELISA for providing AT(N) classification of our patients. AT(N) categories have an impact on disease progression. AT(N) classifiers increase the certainty of the MCI prognosis, which can be instrumental in managing real-world MCI subjects.     

Evaluation of Coupling Agents in Poly(propylene)/Fly Ash Composites: Effect on Processing and Mechanical Properties

Composites containing 50 wt.‐% fly ash in a PP homopolymer were prepared via batch mixing and compression moulding. The following coupling agents were evaluated: Lubrizol Solplus C800, N,N′‐(1,3‐phenylene)dimaleimide, γ‐methacryloxypropyltrimethoxysilane and maleic‐anhydride‐grafted PP. At the filler level investigated, C800 gave the best balance of composite strength and toughness. In the latter case filler‐matrix adhesion appeared weaker relative to γ‐MPS, BMI and m‐PP, all of which gave excessively strong filler‐matrix adhesion leading to a reduction in composite toughness. The unexpected weakness of the C800/fly ash interaction may be related to removal of surface calcium ions from the fly ash via reaction of a single calcium ion with two C800 molecules.

     

Essential and non essential amino acid content of infant cereals in different stages of industrial processing and its relationship with chemical scores of protein quality

The effect of technological process on essential and non essential amino acids contents in infant cereals, the protein and essential amino acids infant dietary requirements cover by infant cereals, and its quality using some chemical scores has been studied. Mix of raw flours, mix of roasted flours, mix of enzymatically, hydrolysed and drum dried flours and commercial infant cereals of four different types of infant cereals: "Multicereal" and "Wheat" (both with gluten), "Growth" and "Rice and carrot" (both gluten free) were evaluated. The technological process only show a significant effect on lysine, arginine (P < 0.05) and valine (P < 0.01) contents in "Rice and carrot" infant cereal. Protein of any studied infant cereals covers 17.4% of the daily infant requirements in, while for essential amino acids will cover about 25 to 200% until the third year of life. As we expected, the limitant amino acid was lysine in all flours. Chemical scores only were affected by technological treatment in "Rice and carrot" infant cereal, showing the gluten-free infant cereals higher values (36.7-69.5%) than gluten infant cereals (18.1%-30.7%) at the end of the processing. It should be standing out "Growth" infant cereal, because of it has a higher lysine content than other infant cereals due to the main ingredients rice and corn.     

Understanding the impact of texture on the micromechanical anisotropy of laser powder bed fused Inconel 718

Journal of Materials Science - The manufacturability of metallic alloys using laser-based additive manufacturing methods such as laser powder bed fusion has substantially improved within the last...     

Critical Review on Fatty Acid-Based Food and Nutraceuticals as Supporting Therapy in Cancer

Fatty acids have an important place in both biological and nutritional contexts and, from a clinical point of view, they have known consequences for diseases’ onset and development, including cancer. The use of fatty acid-based food and nutraceuticals to support cancer therapy is a multidisciplinary subject, involving molecular and clinical research. Knowledge regarding polyunsaturated fatty acids essentiality/oxidizability and the role of lipogenesis-desaturase pathways for cell growth, as well as oxidative reactivity in cancer cells, are discussed, since they can drive the choice of fatty acids using their multiple roles to support antitumoral drug activity. The central role of membrane fatty acid composition is highlighted for the application of membrane lipid therapy. As fatty acids are also known as biomarkers of cancer onset and progression, the personalization of the fatty acid-based therapy is also possible, taking into account other important factors such as formulation, bioavailability and the distribution of the supplementation. A holistic approach emerges combining nutra- and pharma-strategies in an appropriate manner, to develop further knowledge and applications in cancer therapy.     

Unprecedented Improvement of Single Li‐Ion Conductive Solid Polymer Electrolyte Through Salt Additive

Solid‐state lithium metal (Li°) batteries (SSLMBs) are believed to be the most promising technologies to tackle the safety concerns and the insufficient energy density encountered in conventional Li‐ion batteries. Solid polymer electrolytes (SPEs) inherently own good processability and flexibility, enabling large‐scale preparation of SSLMBs. To minimize the growth of Li° dendrites and cell polarization in SPE‐based SSLMBs, an additive‐containing single Li‐ion conductive SPE is reported. The characterization results show that a small dose of electrolyte additive (2 wt%) substantially increases the ionic conductivity of single Li‐ion conductive SPEs as well as the interfacial compatibility between electrode and SPE, allowing the cycling of SPE‐based cells with good electrochemical performance. This work may provide a paradigm shift on the design of highly cationic conductive electrolytes, which are essential for developing safe and high‐performance rechargeable batteries.     

High-Impact PLA in Compatibilized PLA/PCL Blends: Optimization of Blend Composition and Type and Content of Compatibilizer

In this work, the effectiveness of seven commercial compatibilizers is tested in polylactide (PLA)/poly(ε-caprolactone) (PCL) blends with different compositions to obtain a high-impact PLA. None of the compatibilizers is effective for 90/10 and 80/20 PLA/PCL compositions, as no improvement of the impact strength is observed. For the 70/30 composition, compatibilizers having glycidyl methacrylate (GMA) and acrylate groups in their structure are proved the most effective, as the morphological change towards co-continuity induced by them leads to significant impact strength improvements (of ≈345% and 90% with respect to the neat PLA and the noncompatibilized PLA/PCL 70/30 blend, respectively). The 70/30 PLA/PCL composition, as it shows the best balance of properties, and the best compatibilizer (ElvaloyPTW) are chosen to carry out the optimization of the compatibilizer content. It is found that adding 6 phr to the blend results in highly toughened and ductile blends while maintaining a high modulus and yield strength values. Larger compatibilizer contents lead to even higher impact strength values, but the low-strain mechanical properties are notably reduced. Thus, in this work, a simple and easily scalable method to produce high-impact PLA is shown, as it implies the compounding of three commercially available components without involving any toxic solvents.