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Nanostructured 3-D collagen/nanotube biocomposites for future bone regeneration scaffolds 总被引:1,自引:0,他引:1
Edelma E. da Silva Heloisa H. M. Della Colleta Andre S. Ferlauto Roberto L. Moreira Rodrigo R. Resende Sergio Oliveira Gregory T. Kitten Rodrigo G. Lacerda Luiz O. Ladeira 《Nano Research》2009,2(6):462-473
The field of bionanotechnology has been rapidly growing during the last few years and we can now envision a controllable integration
between biological and artificial matter, where new biomimetic structures with a wide range of chemical and physical properties
will promote the development of a novel generation of medical devices. In this work we describe a collagen/carbon nanotube
composite which has the potential to be used as a scaffold for tissue regeneration. Because this biocomposite incorporates
the advantageous properties of both collagen and carbon nanotubes, it has most of the characteristics that an ideal biomaterial
requires in order to be used as an osteoinductive agent. This biocomposite is bioresorbable and biodegradable and has the
desired mechanical rigidity while maintaining a three-dimensional(3-D) nanostructured surface. Tuned stability and swelling
were achieved under fluid environments by varying the amount of carbon nanotubes (CNTs) incorporated into the composite. These
variations can dictate the degree of interaction between fibroblastic cells and the biomaterials. Proof-of-concept was shown
by performing an in vitro induced mineralization of hydroxylapatite crystals under physiological conditions. Furthermore, the ability to attach biofunctional
groups to the CNT walls can open a new road for tissue regeneration since the combination of CNTs with specific growth factors
or cellular ligands can create an environment capable of signaling and influencing specific cell functions. Our observations
suggest that collagen/carbon nanotube biocomposites will have important uses in a wide range of biotechnological areas.
Electronic Supplementary Material Supplementary material is available for this article at and is accessible for authorized users. 相似文献
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Donald C. Aduba Jr. Seon-Sook An Gretchen S. Selders W. Andrew Yeudall Gary L. Bowlin Todd Kitten 《国际聚合物材料杂志》2019,68(11):660-668
Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby–Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds. 相似文献
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