Characterization of the Residence Time Distribution in Spray Dryers

In this work it is presented a study on the residence time distribution (RTD) of particles in a co-current pilot-plant spray dryer operated with a rotary atomization system. A nuclear technique is applied to investigate the RTD responses of spray dryers. The methodology is based on the injection of a radioisotope tracer in the feed stream followed by the monitoring of its concentration at the outlet stream. The experiments were performed during the drying of aqueous suspensions of gadolinium oxide. The RTD responses obtained experimentally presented good reproducibility, indicating that the technique applied is well suited to investigating fluid-dynamics of spray dryers. In addition to the experimental investigation, a mathematical model was used to describe the RTD experimental curves.     

Synthesis and physicochemical characterization of a well-defined poly(butadiene 1,3)-block-poly(dimethylsiloxane) copolymer

For the first time, order-order and order-disorder transitions were detected and characterized in a model diblock copolymer of poly(butadiene-1,3) and poly(dimethylsiloxane) (PB-b-PDMS). This model PB-b-PDMS copolymer was synthesized by the sequential anionic polymerization (high vacuum techniques) of butadiene 1,3 (B) and hexamethylciclotrisiloxane (D₃), and subsequently characterized by nuclear magnetic resonance (¹H and ¹³C NMR), size exclusion chromatography (SEC), Fourier Transform infrared spectroscopy (FTIR), Small-Angle X-ray scattering (SAXS) and rheology. SAXS combined with rheological experiments shows that the order-order and order-disorder transitions are thermoreversible. This fact indicates that the copolymer has sufficient mobility at the timescale and at the temperatures of interest to reach their equilibrium morphologies.     

Genotoxic effect of Physalis angulata L. (Solanaceae) extract on human lymphocytes treated in vitro

Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects of aqueous extract of P. angulata using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with P. angulata extracts were performed in vitro in order to access the extent of DNA damage. The comet assay has shown that treatments with P. angulata at 0.5, 1.0, 2.0, 3.0 and 6.0 microg/mL in culture medium were genotoxic. Lymphocytes treated with P. angulata at the concentrations of 3.0 and 6.0 microg/mL in culture medium showed a statistically significant increase in the frequency of micronucleus (p<0.05), however, the cytokinesis blocked proliferation index (CBPI) was not decreased after P. angulata treatment. In conclusion, the present work demonstrated the genotoxic effects of P. angulata extract on human lymphocytes in vitro.     

A survey on approaches to gridification

The Grid shows itself as a globally distributed computing environment, in which hardware and software resources are virtualized to transparently provide applications with vast capabilities. Just like the electrical power grid, the Grid aims at offering a powerful yet easy‐to‐use computing infrastructure to which applications can be easily ‘plugged’ and efficiently executed. Unfortunately, it is still very difficult to Grid‐enable applications, since current tools force users to take into account many details when adapting applications to run on the Grid. In this paper, we survey some of the recent efforts in providing tools for easy gridification of applications and propose several taxonomies to identify approaches followed in the materialization of such tools. We conclude this paper by describing common features among the proposed approaches, and by pointing out open issues and future directions in the research and development of gridification methods. Copyright © 2007 John Wiley & Sons, Ltd.     

Bridging the Gap between Legal and Technical Contracts

Two or more parties typically establish a business relationship using a contract, but a large gap still exists between the provisions of contracts produced by lawyers and the details of computer security and performance addressed by technologists. Some contractual clauses address legal issues that technology can manage as well - the TrustCoM framework offers a paradigm for automating these clauses as technical operations. If a business relationship forms across a service-oriented architecture, the parties involved often manage their collaboration as a virtual organization (VO). In TrustCoM, agreements are the key means of steering VO collaborations and mitigating the risks inherent in integrating processes and resources across organizational boundaries.     

Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach

Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients’ samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs’ roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia.     

Molds and Resists Studies for Nanoimprint Lithography of Electrodes in Low-Voltage Polymer Thin-Film Transistors

A low-cost patterning of electrodes was investigated looking forward to replacing conventional photolithography for the processing of low-operating voltage polymeric thin-film transistors. Hard silicon, etched by sulfur hexafluoride and oxygen gas mixture, and flexible polydimethylsiloxane imprinting molds were studied through atomic force microscopy (AFM) and field emission gun scanning electron microscopy. The higher the concentration of oxygen in reactive ion etching, the lower the etch rate, sidewall angle, and surface roughness. A concentration around 30 % at 100 mTorr, 65 W and 70 sccm was demonstrated as adequate for submicrometric channels, presenting a reduced etch rate of 176 nm/min. Imprinting with positive photoresist AZ1518 was compared to negative SU-8 2002 by optical microscopy and AFM. Conformal results were obtained only with the last resist by hot embossing at 120 °C and 1 kgf/cm² for 2 min, followed by a 10 min post-baking at 100 °C. The patterning procedure was applied to define gold source and drain electrodes on oxide-covered substrates to produce bottom-gate bottom-contact transistors. Poly(3-hexylthiophene) (P3HT) devices were processed on high-κ titanium oxynitride (TiO _x N _y ) deposited by radiofrequency magnetron sputtering over indium tin oxide-covered glass to achieve low-voltage operation. Hole mobility on micrometric imprinted channels may approach amorphous silicon (～0.01 cm²/V s) and, since these devices operated at less than 5 V, they are not only suitable for electronic applications but also as sensors in aqueous media.     

Light and Strong SiC Networks

The directional freezing of microfiber suspensions is used to assemble highly porous (porosities ranging between 92% and 98%) SiC networks. These networks exhibit a unique hierarchical architecture in which thin layers with honeycomb‐like structure and internal strut length in the order of 1–10 μm in size are aligned with an interlayer spacing ranging between 15 and 50 μm. The resulting structures exhibit strengths (up to 3 MPa) and stiffness (up to 0.3 GPa) that are higher than aerogels of similar density and comparable to other ceramic microlattices fabricated by vapor deposition. Furthermore, this wet processing technique allows the fabrication of large‐size samples that are stable at high temperature, with acoustic impedance that can be manipulated over one order of magnitude (0.03–0.3 MRayl), electrically conductive and with very low thermal conductivity. The approach can be extended to other ceramic materials and opens new opportunities for the fabrication of ultralight structures with unique mechanical and functional properties in practical dimensions.     

Low Cost BIST for Static and Dynamic Testing of ADCs

This paper presents a low cost test method for the static and dynamic characterization of analog-to-digital converters. The method is suitable for implementation in a SoC environment, as a built-in self test (BIST) solution. In the proposed approach, noise is used as the test signal. Theory of operation and practical results demonstrating the effectiveness of the method for INL, DNL, THD and SINAD characterization are presented. The BIST surface overhead caused by the noise generator is only 7.4% of the ADC total area. The reduced number of data samples required allows a reduction of about 7.5× in test time, in comparison to the histogram method.Maria da Gloria Cataldi Flores was born in Santa Maria, Brazil, in 1978. She received the electrical engineering degree in 2000 from Universidade Federal de Santa Maria (UFSM) and the M.S. degree engineering in 2003 from Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. Since then, she has been working as a design engineer in an EAS Supply brazilian company. Her main research interests include mixed-signal and analog testing and digital signal processing.Marcelo Negreiros was born in Porto Alegre, Brazil, in 1969. He received the electrical engineering degree in 1992 and the M.S. degree engineering in 1994, both from Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. Since then he was been working as an associate researcher in the Signal Processing Lab. (LaPSI) of the Electrical Engineering Department at UFRGS. Since 2000 he also works toward a Ph.D. in Computer Science from UFRGS. His main research interests include mixed-signal and analog testing and digital signal processing.Luigi Carro was born in Porto Alegre, Brazil, in 1962. He received the Electrical Engineering and the M.Sc. degrees from Universidade Federal do Rio Grande do Sul (UFRGS), Brazil, in 1985 and 1989, respectively. From 1989 to 1991 he worked at ST-Microelectronics, Agrate, Italy, in the R&D group. In 1996 he received the Ph.D. degree in the area of Computer Science from Universidade Federal do Rio Grande do Sul (UFRGS), Brazil. He is presently a lecturer at the Electrical Engineering Department of UFRGS, in charge of Digital Systems Design and Digital Signal processing disciplines at the graduate and undergraduate level. He is also a member of the Graduation Program in Computer Science of UFRGS, where he is responsible for courses in Embedded Systems, Digital Signal Processing, and VLSI Design. His primary research interests include mixed-signal design, digital signal processing, mixed-signal and analog testing, and fast system prototyping. He has published more than 90 technical papers in those topics and is the author of the book Digital Systems Design and Prototyping (in portuguese).Altamiro A Susin was born in Vacaria-RS, Brazil, in 1945. He received the Electrical Engineering and the MSc. degrees from Universidade Federal do Rio Grande do Sul (UFRGS), Brazil, in 1972 and 1977, respectively. Since 1968 he worked in the start up of Computer Centers of two local Universities. In 1981 he got his Dr. Eng degree from Institut National Polytechnique de Grenoble-France. He is presently a lecturer at the Electrical Engineering Department of UFRGS, in charge of Digital Systems Design disciplines at the graduate and undergraduate level. He is also a member of the Graduation Program in Computer Science of UFRGS, where he is responsible by courses in VLSI Architecture and is also thesis director. His main research interests are Integrated Circuit Architecture, Embedded Systems, Signal Processing with more than 50 technical papers published in those domains. He is/was responsible for several R&D projects either funded with public and/or industry resources.Felipe Ricardo Clayton received the B.S. degree in Electrical Engineering from State University of Campinas (UNICAMP), Brazil, in 1986. He worked at CPqD (Brazilian PTT R&D Center) till 1996 designing analog and mixed signal circuits for telecom and automotive applications. From 1997 to the second half of 1998, he worked at Instituto Superior Técnico (IST), Lisbon, Portugal, under the guidance of Prof. Carlos Azeredo Leme on development of CMOS RF circuits. Since October 1998 he had worked for Motorola SPS. Now he is head of the Power Managment Group at Freescale.Cristiano Benevento received his B.S. degree in Electrical Engineering from Universidade Estadual de Campinas (Unicamp), Brazil, in 1997. He worked at Motorola Cellular Infrastructure Group until August 2000 as a Systems Engineer. He joined Motorola Semiconductor Product Sector in August 2000 as IC Designer for Power Management Group and is now at Freescale.