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排序方式: 共有106条查询结果,搜索用时 15 毫秒
1.
Serena Montalbano Francesca Degola Jennifer Bartoli Franco Bisceglie Annamaria Buschini Mauro Carcelli Donatella Feretti Serena Galati Laura Marchi Nicol Orsoni Giorgio Pelosi Marianna Pioli Francesco M. Restivo Dominga Rogolino Mirco Scaccaglia Olga Serra Giorgio Spadola Gaia C. V. Viola Ilaria Zerbini Claudia Zani 《International journal of molecular sciences》2021,22(9)
The control of the fungal contamination on crops is considered a priority by the sanitary authorities of an increasing number of countries, and this is also due to the fact that the geographic areas interested in mycotoxin outbreaks are widening. Among the different pre- and post-harvest strategies that may be applied to prevent fungal and/or aflatoxin contamination, fungicides still play a prominent role; however, despite of countless efforts, to date the problem of food and feed contamination remains unsolved, since the essential factors that affect aflatoxins production are various and hardly to handle as a whole. In this scenario, the exploitation of bioactive natural sources to obtain new agents presenting novel mechanisms of action may represent a successful strategy to minimize, at the same time, aflatoxin contamination and the use of toxic pesticides. The Aflatox® Project was aimed at the development of new-generation inhibitors of aflatoxigenic Aspergillus spp. proliferation and toxin production, through the modification of naturally occurring molecules: a panel of 177 compounds, belonging to the thiosemicarbazones class, have been synthesized and screened for their antifungal and anti-aflatoxigenic potential. The most effective compounds, selected as the best candidates as aflatoxin containment agents, were also evaluated in terms of cytotoxicity, genotoxicity and epi-genotoxicity to exclude potential harmful effect on the human health, the plants on which fungi grow and the whole ecosystem. 相似文献
2.
Stephen Gilmore L��szl�� G?nczy Nora Koch Philip Mayer Mirco Tribastone D��niel Varr�� 《Software and Systems Modeling》2011,10(3):287-311
Systems based on the service-oriented architecture (SOA) principles have become an important cornerstone of the development
of enterprise-scale software applications. They are characterized by separating functions into distinct software units, called
services, which can be published, requested and dynamically combined in the production of business applications. Service-oriented
systems (SOSs) promise high flexibility, improved maintainability, and simple re-use of functionality. Achieving these properties
requires an understanding not only of the individual artifacts of the system but also their integration. In this context,
non-functional aspects play an important role and should be analyzed and modeled as early as possible in the development cycle.
In this paper, we discuss modeling of non-functional aspects of service-oriented systems, and the use of these models for
analysis and deployment. Our contribution in this paper is threefold. First, we show how services and service compositions
may be modeled in UML by using a profile for SOA (UML4SOA) and how non-functional properties of service-oriented systems can
be represented using the non-functional extension of UML4SOA (UML4SOA-NFP) and the MARTE profile. This enables modeling of
performance, security and reliable messaging. Second, we discuss formal analysis of models which respect this design, in particular
we consider performance estimates and reliability analysis using the stochastically timed process algebra PEPA as the underlying
analytical engine. Last but not least, our models are the source for the application of deployment mechanisms which comprise
model-to-model and model-to-text transformations implemented in the framework VIATRA. All techniques presented in this work
are illustrated by a running example from an eUniversity case study. 相似文献
3.
Preserving individual privacy when publishing data is a problem that is receiving increasing attention. Thanks to its simplicity the concept of k-anonymity, introduced by Samarati and Sweeney [1], established itself as one fundamental principle for privacy preserving data publishing. According to the k-anonymity principle, each release of data must be such that each individual is indistinguishable from at least k−1 other individuals. 相似文献
4.
Michele Lionello Riccardo Lucchese Mirco Rampazzo Martin Guay Khalid Atta 《International Journal of Adaptive Control and Signal Processing》2021,35(7):1298-1315
This paper considers the problem of optimizing the operation of Indirect Adiabatic Cooling (IAC) systems with application to data centers. Optimal operation is achieved when the required cooling demand is satisfied at the minimum energy cost. For this purpose, we design a supervisory control system, where the higher layer determines the optimal set-points for the local controllers by employing an Extremum Seeking Control (ESC) scheme. In particular, we consider a Newton-like phasor ESC, which augments the derivative estimator underlying the phasor approach to capture also the Hessian of the plant index and then it uses these estimates to steer the system along a Newton-like direction. The effectiveness of the considered approach is tested in simulation by exploiting a Matlab-based simulation environment including an IAC system and a computer room. 相似文献
5.
The low temperature photoluminescence under bias (PLb) and the photoconductivity (PC) of a p-i-n GaInNAs/GaAs multiple quantum well sample have been investigated. Under optical excitation with photons of energy greater than the GaAs bandgap, PC and PLb results show a number of step-like increases when the sample is reverse biased. The nature of these steps, which depends upon the temperature, exciting wavelength and intensity and the number of quantum wells (QWs) in the device, is explained in terms of thermionic emission and negative charge accumulation due to the low confinement of holes in GaInNAs QWs. At high temperature, thermal escape from the wells becomes much more dominant and the steps smear out. 相似文献
6.
Mirco Wegener Luckman Muhmood Shouyi Sun Alex V. Deev 《American Institute of Chemical Engineers》2014,60(9):3350-3361
The experiments on the capillary breakup of slag jets at high temperatures are presented in this article. The impact of external excitations on the disintegration process was investigated in a furnace with optical access filmed at frame rates up to 10,000 fps. A synthetic calcia‐alumina slag was used to form jets at different temperatures (1570–1660°C) and jet velocities (0.6–1.4 ms?1). The impact of external vibration on the breakup was evident: for low jet velocities, the jet length decreased, the droplet size increased, satellite droplet formation was hindered, and a distinct “pumping mechanism” was observed. For jets with higher velocity, the jet length decreased by 30%, the droplet generation frequency increased from 20 to 250 droplets per second, the drop sizes were uniform, and satellite formation was also suppressed. In this case, the ideal case in which the volume of one wave instability forms one droplet was achieved. © 2014 American Institute of Chemical Engineers AIChE J, 60: 3350–3361, 2014 相似文献
7.
Piero Portincasa Leonilde Bonfrate Mirco Vacca Maria De Angelis Ilaria Farella Elisa Lanza Mohamad Khalil David Q.-H. Wang Markus Sperandio Agostino Di Ciaula 《International journal of molecular sciences》2022,23(3)
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and related metabolites have profound effects on human health. In this respect, gut microbiota plays a pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolites include the short chain fatty acids (SCFAs) acetate (C2), propionate (C3), and butyrate (C4), which are the most abundant SCFAs in the human body and the most abundant anions in the colon. SCFAs are made from fermentation of dietary fiber and resistant starch in the gut. They modulate several metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes. Thus, diet might influence gut microbiota composition and activity, SCFAs production, and metabolic effects. In this narrative review, we discuss the relevant research focusing on the relationship between gut microbiota, SCFAs, and glucose metabolism. 相似文献
8.
Mariana Mazzucato 《Industry and innovation》2016,23(2):140-156
Many countries are pursuing innovation-led “smart” growth, which requires long-run strategic investments and public policies that aim to create and shape markets, rather than just “fixing” markets or systems. Market creation has characterized the kind of mission-oriented investments that led to putting a man on the moon and are currently galvanizing green innovation. Mission-oriented innovation has required public agencies to not only “de-risk” the private sector, but also to lead the direct creation of new technological opportunities and market landscapes. This paper considers four key issues that arise from a market-creating framework for policy: (1) decision-making on the direction of change; (2) the nature of (public and private) organizations that can welcome the underlying uncertainty and discovery process; (3) the evaluation of mission-oriented and market-creation policies; and (4) the ways in which both risks and rewards can be shared so that smart growth can also result in inclusive growth. 相似文献
9.
Mirco Wegener Matthias Kraume Anja R. Paschedag 《American Institute of Chemical Engineers》2010,56(1):2-10
The knowledge of the drop rise velocity in dispersed systems is of fundamental importance. Especially, the residence time is needed for calculation of mass transfer rates in extraction columns. This work deals with fluid dynamic measurements of toluene droplets rising in water ranging from 1.0 to 7.0 mm, with the premise of high purity of the used chemicals. The toluene/water‐system is widely used as a test system with high interfacial tension. A semiempirical correlation for pure systems to predict the terminal velocity of single rising/falling droplets based on experimental data is presented. Results show that a distinction between maximum and characteristic mean values of the drop rise velocity is necessary, especially in the diameter range 2.4–3.0 mm where unexpected velocity fluctuations occur. Two distinct terminal rise velocities were observed for 3 mm droplets. Furthermore, comparisons of the Weber‐Reynolds‐correlation and the drag coefficient with correlations from literature show good agreement. © 2009 American Institute of Chemical Engineers AIChE J, 2009 相似文献
10.
Advanced treatment techniques, like ozone, activated carbon and TiO2 in combination with UV, are proposed to improve removal efficiency of micropollutants during wastewater treatment. In a meta-analysis of peer-reviewed literature, we found significantly reduced overall ecotoxicity of municipal wastewaters treated with either ozone (n = 667) or activated carbon (=113), while TiO2 and UV was not yet assessed. As comparative investigations regarding the detoxification potential of these advanced treatment techniques in municipal wastewater are scarce, we assessed them in four separate Gammarus-feeding trials with 20 replicates per treatment. These bioassays indicate that ozone concentrations of approximately 0.8 mg ozone/mg DOC may produce toxic transformation products. However, referred effects are removed if higher ozone concentrations are used (1.3 mg ozone/mg DOC). Moreover, the application of 1 g TiO2/l and ambient UV consistently reduced ecotoxicity. Although activated carbon may remove besides micropollutants also nutrients, which seemed to mask its detoxification potential, this treatment technique reduced the ecotoxicity of the wastewater following its amendment with nutrients. Hence, all three advanced treatment techniques are suitable to reduce the ecotoxicity of municipal wastewater mediated by micropollutants and may hence help to meet the requirements of the European Water Framework Directive. 相似文献