Creating geometrically robust designs for highly sensitive problems using topology optimization

Resonance and wave-propagation problems are known to be highly sensitive towards parameter variations. This paper discusses topology optimization formulations for creating designs that perform robustly under spatial variations for acoustic cavity problems. For several structural problems, robust topology optimization methods have already proven their worth. However, it is shown that direct application of such methods is not suitable for the acoustic problem under consideration. A new double filter approach is suggested which makes robust optimization for spatial variations possible. Its effect and limitations are discussed. In addition, a known explicit penalization approach is considered for comparison. For near-uniform spatial variations it is shown that highly robust designs can be obtained using the double filter approach. It is finally demonstrated that taking non-uniform variations into account further improves the robustness of the designs.     

Shot-noise limited,supercontinuum-based optical coherence tomography

We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of ...     

Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique. Sophion Bioscience is aiming to meet this challenge by developing two lines of automated patch clamp products, a traditional pipette-based system called Apatchi-1, and a silicon chip-based system QPatch. The degree of automation spans from semi-automation (Apatchi-1) where a trained technician interacts with the system in a limited way, to a complete automation (QPatch 96) where the system works continuously and unattended until screening of a full compound library is completed. The performance of the systems range from medium to high throughputs.     

Non-Hierarchical Architected Materials with Extreme Stiffness and Strength

Stretch-dominated truss and plate microstructures are contenders in the quest for realizing architected materials with extreme stiffness and strength. In the low volume fraction limit, closed-cell isotropic plate microstructures meet theoretical upper bounds on stiffness but have low buckling strength, whereas open-cell truss microstructures have high buckling strength at the cost of significantly reduced stiffness. At finite volume fractions, the picture becomes less clear but both are outperformed by hollow truss lattice and hierarchical microstructures in terms of buckling strength. Despite significant advances in manufacturing methods, hollow and multi-scale hierarchical microstructures are still challenging to build. The question is if there exist realizable microstructures providing stiffness and strength matching or even beating hard-to-realize hollow or hierarchical microstructures? Herein, single-scale non-hierarchical (first order) microstructures that beat the buckling strength of hollow truss lattice structures by a factor of 2.4 and first- and second-order plate microstructures by factors of 5 and 1.4, respectively, are systematically designed, built, and tested. Stiffness of the microstructures is within 40% of theoretical bounds and beats both truss and second order plate microstructures. The microstructures are realized with 3D printing. Experiments validate theoretical predictions and additional insight is provided through numerical modeling of a CT-scanned sample.     

On the effect of peroxisomal β-oxidation and carnitine palmitoyltransferase activity by eicosapentaenoic acid in liver and heart from rats

Repeated administration of highly purified eicosapentaenoic acid (as ethyl ester) resulted in a decrease in plasma triglycerides and high density lipoprotein (HDL) cholesterol. This was accompanied by a stimulation in the activities of carnitine palmitoyltransferase, fatty acyl-CoA oxidase and peroxisomal β-oxidation in the liver. The results suggest that the triglyceride-lowering effect observed with eicosapentaenoic acid may be due to a reduced supply of fatty acids for hepatic triglyceride synthesis because of increased fatty acid oxidation. Eicosapentaenoic acid feeding marginally affected the triglyceride content of heart and mitochondrial and peroxisomal enzyme activities.     

扩声系统语言清晰度的测量

用户都希望自己的扩声系统能满足多种使用需求、声音均匀覆盖全部区域、便于操作并且维护简单,其中最重要的评价标准有以下几点：（1）扩声系统有正确的高频、中频、低频比例,即“音色平衡”;（2）扩声系统播放声音的响度要合适;（3）扩声系统的声音来自正确的方向;（4）扩声系统播放清晰透彻的音乐和语言声音;（5）扩声系统要足够稳定可靠。     

A Chip for an Implantable Neural Stimulator

This paper describes a chip for a multichannel neural stimulator for functional electrical stimulation (FES). The purpose of FES is to restore muscular control in disabled patients. The chip performs all the signal processing required in an implanted neural stimulator. The power and digital data transmission to the stimulator passes through a 5 MHz inductive link. From the signals transmitted to the stimulator, the chip is able to generate charge-balanced current pulses with a controllable length up to 256 s and an amplitude up to 2 mA, for stimulation of nerve fibers. The quiescent current consumption of the chip is approx. 650 A at supply voltages of 6–12 V, and its size is 3.9×3.5 mm². It has 4 output channels for use in a multipolar cuff electrode.     

利用现代智能电池技术延长电池寿命

锂离子电池因其能量密度高而在便携应用中倍受青睐。但其电池管理系统并不尽如人意。结果不是电池比预期提前结束寿命就是造成剩余电量的浪费。针对对这种情况,智能电源管理系统应运而生,能够准确地对电池剩余电量进行估计,令电池的使用达到最佳化。     

UTRA/FDD RF Transceiver Requirements

Unified RF requirements are derived for an UMTS Terrestrial RadioAccess/Frequency Division Duplex (UTRA/FDD) compliant mobile transceiver. Aset of transceiver requirements are proposed with consideration to systemissues including duplex aspects. From these design-compatible requirements areproposed for each functional block in the transceiver.     

Deployment of Mobile Switching Centers in a Telecommunications Network: A Stochastic Programming Approach

We consider a network design problem arising in mobile communications. At the core of the network is a number of mobile switching centers (MSCs), each serving a number of base station controllers (BSCs). The network design problem involves three major groups of decisions – deployment of a number of new MSCs, allocation of BSCs to new and existing MSCs, and capacity expansion of transmission links interconnecting the MSCs. These decisions must be made so as to minimize the incurred costs while meeting customer demand and observing the capacity restrictions. We formulate the problem as a two-stage stochastic program with mixed-integer recourse. To solve the problem we apply a dual decomposition procedure, solving scenario subproblems by means of branch and cut. The solution procedure has been tested on a real life problem instance provided by SONOFON, a Danish mobile communication network operator, and we report results of our computational experiments.