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排序方式: 共有51条查询结果,搜索用时 15 毫秒
1.
Arlinda Ljoki Tanzila Aslam Tina Friis Ragnhild G. Ohm Gunnar Houen 《International journal of molecular sciences》2022,23(8)
A co-culture assay with human umbilical vein endothelial cells (HUVECs) and normal human dermal fibroblasts (NHDFs) was used to study whether selected angiogenesis inhibitors were able to inhibit differentiation and network formation of HUVECs in vitro. The effect of the inhibitors was determined by the morphology and the calculated percentage area covered by HUVECs. Neutralizing VEGF with avastin and polyclonal goat anti-VEGF antibody and inhibiting VEGFR2 with sorafenib and vatalanib resulted in the formation of HUVEC clusters of variable sizes as a result of inhibited EC differentiation. Furthermore, numerous inhibitors of the VEGF signaling pathways were tested for their effect on the growth and differentiation of HUVECs. The effects of these inhibitors did not reveal a cluster morphology, either individually or when combined to block VEGFR2 downstream pathways. Only the addition of N-methyl-p-bromolevamisole revealed a similar morphology as when targeting VEGF and VEGFR2, meaning it may have an inhibitory influence directly on VEGFR signaling. Additionally, several nuclear receptor ligands and miscellaneous compounds that might affect EC growth and differentiation were tested, but only dexamethasone gave rise to cluster formation similarly to VEGF-neutralizing compounds. These results point to a link between angiogenesis, HUVEC differentiation and glucocorticoid receptor activation. 相似文献
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Ragnhild E. Aune Miyuki Hayashi Keiji Nakajima Seshadri Seetharaman 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(11):62-69
The optimization of metallurgical processes requires reliable data of the slag phase. This paper focuses on three properties
that are relevant to heat and mass-transfer calculations — viscosities,thermal diffusivities, and surface tensions of silicate melts. A brief account of the experimental techniques used for the
measurements of these properties, with special reference to the work carried out in the Division of Metallurgy, Royal Institute
of Technology, Stockholm, Sweden, are presented, along with the advantages and limitations. As these properties are structure-oriented,
the impact of structure on these properties is also presented. The paper is intended as a state-of-the-art review of the subject. 相似文献
4.
Dereje T. Asefa Solveig Langsrud Ragnhild O. Gjerde Cathrine F. Kure Maan S. Sidhu Truls Nesbakken Ida Skaar 《Food Control》2009,20(11):997-1001
Performances of SAS-super-180 air sampler and settle plates were investigated for the assessment of airborne fungal food contamination. Air samples were taken from processing rooms of a dry-cured production facility and outdoors. Fungal colonies and numbers of species were counted and compared. Quantitatively, the air sampler showed higher numbers of species and mean CFU/plate compared to settle plates. Qualitatively, the two methods showed similar dominating fungal genera and species associated with dry-cured meat products. The study showed settle plates could provide important qualitative information for food processing plants where airborne fungi associated with food products are the targets. 相似文献
5.
This paper presents a meta-analysis of studies that have evaluated the effects of an edgeline on speed and lateral position of motorised road users. Together with many other study characteristics, 41 estimates of the effects of an edgeline on speed and 65 on lateral position were extracted from the studies. The results of the evaluation studies show a great variety in effects. Both negative and positive effects on speed and lateral position were found; amongst others, increases in speed up to 10.6 km/h, as well as decreases in speed up to 5.0 km/h, and shifts of the lateral position towards the centre of the road up to 30 cm, as well as shifts towards the edge of the road up to 35 cm. Further analyses resulted in the determination of study characteristics that influence the effects of an edgeline on speed and lateral position. It is concluded that the effects of an edgeline on speed are related to the presence of a centreline. Applying an edgeline to a road without a centreline increases the speed of road users, and replacing a centreline by an edgeline decreases the speed. Results with respect to adding an edgeline to a road with a centreline were unclear. Another conclusion is that shoulder width and road environment contribute to the effects of an edgeline on lateral position. In combination with wide shoulders or buildings and/or trees next to the road, edgelines lead to shifts of the lateral position towards the edge of the road, and in combination with narrow shoulders or open fields, edgelines lead to shifts towards the centre of the road. 相似文献
6.
The model-driven architecture enables the deployment of software applications on different platforms. It is based on a pattern in which a platform-independent model is transformed into a platform-specific model, given a platform model (PM). Currently, the model transformations used for this task implicitly assume this PM, which makes it unclear whether a model transformation can be used for platforms other than the one assumed. In order to target very specific platforms and platform variants, model transformations must be reusable beyond their assumed platform. We propose an explicit PM that can be used to reason about platform dependencies of model transformations and their applicability to specific platforms. In addition, we show how PMs can be integrated in a model-driven configuration management framework. 相似文献
7.
Having a sequence diagram specification and a computer system, we need to answer the question: Is the system compliant with the sequence diagram specification in the desired way? We present a procedure for answering this question for sequence diagrams with underspecification and inherent nondeterminism. The procedure is independent of any concrete technology, and relies only on the execution traces that may be produced by the system. If all traces are known, the procedure results in either “compliant” or “not compliant”. If only a subset of the traces is known, the conclusion may also be “likely compliant” or “likely not compliant”. 相似文献
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9.
Marjan P. Hagenzieker Frits D. Bijleveld Ragnhild J. Davidse 《Accident; analysis and prevention》1997,29(6):759-777
The effects of campaigns using tangible incentives (rewards) to promote safety belt usage have been evaluated by means of a meta-analytic approach. Two coders extracted a total number of 136 short-term and 114 long-term effect sizes and coded many other variables from 34 journal articles and research reports. The results show a mean short-term increase in use rates of 20.6 percentage points; the mean long-term effect was 13.7 percentage points. Large scale studies report smaller effect sizes than small scale studies; when studies were weighted by the (estimated) number of observations, the weighted mean effect sizes were 12.0 and 9.6 percentage points for the short and long term, respectively. The main factors that influence the magnitude of the reported short-term effect of the programs were the initial baseline rate (which was highly correlated with the presence or absence of a safety belt usage law), the type of population involved, whether incentives were delivered immediately or delayed, and whether incentives were based on group or individual behaviour. Together these four variables accounted for 64% of the variance. Other variables, such as the duration of the intervention, the probability of receiving a reward, and the value of the reward were not related to the short-term effect sizes. The relationship between moderating variables and long-term effects was less clear. 相似文献
10.
A gas chromatographic method for evaluating the effect of antioxidants is described. Emulsions of linoleic acid both with
and without antioxidant are oxidized enzymatically. Concentrations of uncreacted linoleic acid are measured at varying incubation
times and various concentrations of both lipoxidase and antioxidant. Two antioxidants have been tested. The method is simple,
precise, and reproducible. The inhibition mechanism and experimental conditions are discussed. 相似文献