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Kandukuri Rama Krishna Achterhold Jan Moeller Michael Stueckler Joerg 《International Journal of Computer Vision》2022,130(1):3-16
International Journal of Computer Vision - Representation learning for video is increasingly gaining attention in the field of computer vision. For instance, video prediction models enable activity... 相似文献
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Clemens Stueckler Christoph K. Winkler Mlanie Hall Bernhard Hauer Melanie Bonnekessel Klaus Zangger Kurt Faber 《Advanced Synthesis \u0026amp; Catalysis》2011,353(7):1169-1173
α,β‐Dehydroamino acid derivatives proved to be a novel substrate class for ene‐reductases from the ‘old yellow enzyme’ (OYE) family. Whereas N‐acylamino substituents were tolerated in the α‐position, β‐analogues were generally unreactive. For aspartic acid derivatives, the stereochemical outcome of the bioreduction using OYE3 could be controlled by variation of the N‐acyl protective group to furnish the corresponding (S)‐ or (R)‐amino acid derivatives. This switch of stereopreference was explained by a change in the substrate binding, by exchange of the activating ester group, which was proven by 2H‐labelling experiments. 相似文献
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Mlanie Hall Clemens Stueckler Heidemarie Ehammer Eva Pointner Gustav Oberdorfer Karl Gruber Bernard Hauer Rainer Stuermer Wolfgang Kroutil Peter Macheroux Kurt Faber 《Advanced Synthesis \u0026amp; Catalysis》2008,350(3):411-418
Three cloned enoate reductases from the “old yellow enzyme” family of flavoproteins were investigated in the asymmetric bioreduction of activated alkenes. 12‐Oxophytodienoate reductase isoenzymes OPR1 and OPR3 from Lycopersicon esculentum (tomato), and YqjM from Bacillus subtilis displayed a remarkably broad substrate spectrum by reducing α,β‐unsaturated aldehydes, ketones, maleimides and nitroalkenes. The reaction proceeded with absolute chemoselectivity – only the conjugated CC bond was reduced, while isolated olefins and carbonyl groups remained intact – with excellent stereoselectivities (ees up to >99%). Upon reduction of a nitroalkene, the stereochemical outcome could be determined via choice of the appropriate enzyme (OPR1 versus OPR3 or YqjM), which furnished the corresponding enantiomeric nitroalkanes in excellent ee. Molecular modelling suggests that this “enzyme‐based stereocontrol” is caused by subtle differences within the active site geometries. 相似文献
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