Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).

     

Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C-C coupling reaction

Carbon-carbon (C-C) coupling reactions represent one of the most powerful tools for the synthesis of complex natural products, bioactive molecules developed as drugs and agrochemicals. In this work, a multifunctional nanoreactor for C-C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8 (Cu@Ni@ZIF-8). In this nanoreactor, Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center, and Cu core was in situ heating source for the catalyst by absorbing the visible light. Moreover, benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8, the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced. Most importantly, the microporous structure of ZIF-8 provided shape-selective of reactant. This composite was used for the highly shape-selective and stable photocatalysed C-C coupling reaction of boric acid under visible light irradiation. After five cycles, the nanoreactor still remained high catalytical activity. This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C-C coupling reactions with shape-selectivity.

     

Anchoring DTPA grafted PEI onto carboxylated graphene oxide to effectively remove both heavy metal ions and dyes from wastewater with robust stability

Highly efficient adsorbents, which can effectively remove both metal ions and dyes from wastewater with robust stability, are strongly required for the remediation of current polluted aqueous system, but still a challenge to be realized. Herein, a new adsorbent has been designed to solve this problem by anchoring diethylene triamine pentaacetic acid (DTPA) grafted polyethyleneimine (PEI) onto carboxylated GO (GOC-g-PD). Given the amino and carboxyl active groups from PEI and GOC/DTPA, our GOC-g-PD displays good adsorption capacity against not only inorganic metal ions (Cu²⁺ and Pb²⁺) but also organic dye (methylene blue: MB). The maximum adsorption capacity of GOC-g-PD for Cu²⁺, Pb²⁺ and MB reached 309.60 mg·g^?1, 316.17 mg·g^?1 and 262.10 mg·g^?1, respectively. Furthermore, our GOC-g-PD also exhibits good cycling stability and chemical stability against wide pH values. These outstanding properties revealed our GOC-g-PD held great potential in purifying the sewage discharged from industries.

Graphical abstract

     

几种配合料加水系统及特点

分析总结了几种常见配合料加水系统及其特点,并结合生产实际提出了不同系统的利弊和使用要点.     

基于Mapx的城市雨水管理信息系统建设——以徐州市为例

城市雨水资源化对城市雨水的管理提出了新的挑战。文章以GIS技术为依托,以面向水文循环修复为方向,以实现雨水资源的数字化管理为目标,设计并开发城市雨水管理信息系统,寻找一种协调的综合的现代化的雨水管理模式。     

凹凸棒石黏土脱色剂对航空煤油脱色研究

介绍了凹凸棒石黏土作为脱色剂,对航空煤油脱色.通过正交实验研究了活化酸度、焙烧温度、AlCl3加入量、脱色剂的用量和脱色时间对航空煤油脱色的影响.结果表明,经6%的硫酸酸化和450℃焙烧处理后的凹凸棒石黏土,加入1%AlCl;,制备的脱色剂脱色效果最佳,可使航空煤油的脱色率达到98.3%.     

桦树沟矿区东西区开采的合理衔接与规模的探讨

本文简要地论述了镜铁山铁矿桦树沟矿区东、西区开采的现状以及合理的衔接原则,并进一步探讨了该矿区的合理规模。     

矿地产金融初论

本文从经济学角度认为资金是一种特殊资源，具有引导和配置它资源的作用，一定时期的金融制度决定着资金的运动，并从现代公司制度与金融市场的关系以及矿地产业自身的特点，论述了矿地产金融的客观必要性。认为发展矿地产金融的制约因素是矿地产经济的货币化问题，矿地产经济自身的发展以及矿地产金融市场的培育。最后通过对矿地产业与金融业发展客观要求的分析，认为：矿地产金融的主要形式应是证券化。